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Production method of ribavirin

A production method, ribavirin technology, applied in the field of drug preparation, can solve problems such as complicated production process and poor product quality, and achieve the effect of simple manufacturing method and good product quality

Inactive Publication Date: 2015-07-01
李磊
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the current production of Bavirin, the production process is complicated and the product quality is poor

Method used

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Comparison scheme
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Embodiment Construction

[0006] Now in conjunction with the present invention for further detailed description.

[0007] A kind of production method of ribavirin of the present invention, concrete steps are as follows: take nucleoside or nucleotide as raw material, first hydrolyze guanosine and guanylic acid under the effect of glacial acetic acid and acetic anhydride, generate ribose- 1-Phosphoric acid, under the catalysis of bis-p-nitrophenol, reacts with triazide acetamide to form a condensation product, and ribavirin can be obtained through ammonolysis.

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PUM

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Abstract

The invention relates to a production method of ribavirin, wherein the production method comprises the following specific steps: with nucleoside or nucleotide as a raw material, firstly, hydrolyzing guanosine and guanylic acid under the action of glacial acetic acid and acetic anhydride, generating ribose-1-phosphoric acid, then under catalysis of di-p-nitrophenol, carrying out a reaction with triazide amide to generate a condensation compound, carrying out ammonolysis, and thus obtaining ribavirin. According to the production method of ribavirin, the manufacturing method is simple, and the product quality is good.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a production method of ribavirin. Background technique [0002] Ribavirin, also known as ribavirin, ribavirin, niscor, etc., is a broad-spectrum and potent antiviral drug, and is currently widely used in the prevention and treatment of viral diseases. Common dosage forms include injections, tablets, oral liquids, aerosols, etc. Because currently in the production of Bavirin, the production process is complicated and the product quality is poor. Contents of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a production method of ribavirin is provided. [0004] The technical scheme that the present invention adopts to solve its technical problem is: a kind of production method of ribavirin, concrete steps are as follows: take nucleoside or nucleotide as raw material, first with guanosine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H19/056C07H1/00
CPCC07H19/056C07H1/00
Inventor 李磊
Owner 李磊