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Application of single nucleotide polymorphism rs10763170 in detection of pituitary adenoma

A pituitary adenoma and polymorphism technology, applied in the field of biomedicine, can solve the problems of difficult to find microadenomas, high cost, and difficult large-scale screening of clinical cases.

Active Publication Date: 2017-05-03
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, magnetic resonance imaging (MRI), which is clinically used to diagnose pituitary adenoma, is not only expensive, it is difficult to be used for large-scale screening of clinical cases, and due to the limitation of resolution, it is difficult to find micro glands with a diameter of <0.5cm tumor

Method used

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  • Application of single nucleotide polymorphism rs10763170 in detection of pituitary adenoma
  • Application of single nucleotide polymorphism rs10763170 in detection of pituitary adenoma
  • Application of single nucleotide polymorphism rs10763170 in detection of pituitary adenoma

Examples

Experimental program
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Embodiment 1

[0054] Example 1, rs2359536, rs10763170 and rs17083838 are single nucleotide polymorphisms associated with pituitary adenomas

[0055] 1. Research object

[0056] Case group: 3313 patients with pituitary adenoma who were treated and operated in the Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University. The 3,313 patients with pituitary adenoma were all diagnosed as pituitary adenoma by clinical manifestations, endocrine laboratory examination, imaging examination, and histological identification of tumor specimens by more than two pathologists. None of the 3313 patients with pituitary adenoma suffered from other malignant diseases (such as meningioma, glioma, lymphoma, leukemia, lung cancer, gastric cancer, intestinal cancer, breast cancer and cervical cancer, etc.), and the 3313 patients with pituitary adenoma None of them were patients with familial pituitary adenoma. The 3313 patients with pituitary adenoma in the case group were divided into three g...

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Abstract

The invention discloses an application of single nucleotide polymorphism rs10763170 in detection of pituitary adenoma. According to the technical scheme adopted by the invention, a matter for detecting polymorphism (allele) or gene type in human genome rs10763170 is applied to preparing a product for detecting single nucleotide polymorphism associated with pituitary adenoma. The substance or detecting polymorphism or gene type of rs10763170 can be combined with other matters (matters for detecting single nucleotide polymorphism or gene type associated with the pituitary adenoma) to prepare a product for screening a pituitary adenoma patient.

Description

technical field [0001] The invention relates to the application of single nucleotide polymorphism rs10763170 in the detection of pituitary adenoma in the field of biomedicine. Background technique [0002] Pituitary adenomas are the most common neuroendocrine tumors in humans and one of the most common brain tumors. Functional pituitary adenomas can abnormally secrete hormones, leading to infertility, acromegaly, Cushing syndrome, hyperthyroidism and other significant endocrine disorders in patients, which in turn seriously damage the functions of important organs such as the heart, liver and kidney. The onset of pituitary adenoma is hidden and the growth is slow. When the patient presents clinical symptoms and goes to see a doctor, the tumor is often huge in size or invasive in growth, oppressing the adjacent important anatomical structures, resulting in hypopituitarism, binocular vision loss and cranial nerve palsy. Symptoms such as neurological deficit, and even irrevers...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68C12N15/11
Inventor 赵曜师咏勇王镛斐李士其李志强陈剑华寿雪飞沈明叶钊马增翼张启麟宋智健王涛何文强季珏温祖佳周良辅毛颖
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV