A Manipulator Structure for Single-cell Stimulation and Detection of Osteoblasts
An osteoblast and single-cell technology, which is applied in specific-purpose bioreactors/fermenters, biochemical instruments, biochemical equipment and methods, etc., can solve problems such as inability to quantitative analysis, and achieve the effect of dynamic detection.
Active Publication Date: 2017-06-13
北京泰圣康源生物医学研究院有限公司
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[0004] In the prior art, the osteogenic effect of osteoblasts is mainly analyzed through the overall vibration of the whole bone or a large number of osteoblasts, which is relatively general and qualitative, and cannot be quantitatively analyzed, and cannot give accurate evidence from the cell level.
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[0023] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described The embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.
[0024] Because the mechanical characteristics of osteoblasts are related to environmental conditions and cell growth cycle, for a specific batch of cells, firstly, the calculation method of typical mechanical characteristics of the simplified structure of each part of osteoblasts and the biological characteristic parameters are used to t...
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The invention discloses an operating hand structure for stimulating and detecting osteoblast single cells. The operating hand includes a connecting arm, a vibrating arm and two detecting arms installed on the top of the connecting arm. The two detecting arms are symmetrically arranged on On both sides of the vibrating arm, the detection arm is used to clamp osteoblasts and the clamping directions of the two detection arms are oppositely arranged. The vibrating arm is used to vibrate and excite osteoblasts. In-plane piezoresistance for piezoresistivity and sidewall piezoresistance for detection of osteoblast side surfaces. The manipulator structure for excitation and detection of osteoblast single cells adjusts the contact degree between the end of the tool and the cells through the clamping action, and designs a two-dimensional sensing method for detecting the structure of the end of the tool, which can realize global multi-point osteoblasts Multi-dimensional dynamic detection.
Description
technical field [0001] The invention relates to the technical field of osteoblast excitation and detection, in particular to an operator structure for excitation and detection of osteoblast single cells. Background technique [0002] The skeletal system is one of the largest tissue systems in the human body. It has multiple functions such as supporting and protecting the body, maintaining movement, hematopoiesis, and storing calcium. Orthopedic diseases are one of the most common diseases that affect people's health and quality of life. Take osteoporosis as an example. At present, my country is the country with the largest number of osteoporosis patients in the world, with about 90 million patients, accounting for about 10% of the total population. 7%. Among the population over 45 years old in my country, 1 out of 4 men suffers from osteoporosis, and the incidence rate of women is higher, more than 30%. It is estimated that the number of osteoporosis patients in China will ...
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IPC IPC(8): C12M1/34C12M1/00
Inventor 陈涛杨湛刘会聪孙立宁王雅琼
Owner 北京泰圣康源生物医学研究院有限公司