Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of targeted mesoporous molecular imaging probe and preparation method thereof

A molecular imaging and mesoporous technology, applied in material excitation analysis, fluorescence/phosphorescence, nanotechnology, etc., can solve the problems of single emission wavelength of nanocrystals and the inability to adjust the emission wavelength, etc., and achieve the effect of high fluorescence characteristics

Inactive Publication Date: 2017-09-15
UNIV OF ELECTRONICS SCI & TECH OF CHINA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned fluorescent probes based on gold nanomaterials in the prior art have solved the problems of safety and stability well, they all have a single luminescence wavelength of nanocrystals, which cannot be adjusted to suit the luminescence wavelength of fluorescent tissues, and provide high Problems with Brightness Fluorescence Imaging

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of targeted mesoporous molecular imaging probe and preparation method thereof
  • A kind of targeted mesoporous molecular imaging probe and preparation method thereof
  • A kind of targeted mesoporous molecular imaging probe and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of targeted mesoporous molecular imaging probes

[0026] (1) Preparation of a solution of gold nanorods: 30 μl, CTAB of 0.02mol / L, 30 μl n-butanol, 120 μl n-octane and 100 μl aqueous solution of 1% chloroauric acid were mixed together, stirred and mixed evenly to make a dispersion Uniform and transparent microemulsion; add 100μl 1% sodium citrate to 10ml ultrapure water to form a sodium citrate aqueous solution, and add the sodium citrate aqueous solution dropwise to the microemulsion under stirring; then add 0.05ml of 1,6 -Dimercaptohexane, continue to stir and react for 12h to obtain a suspension of gold nanorod-solution, wherein the diameter range of gold nanorod-1 is 15nm~23nm, and the aspect ratio range satisfies Then let it stand for 24 hours to completely precipitate the suspended particles therein, take out the upper layer solution, and add ethanol to the remaining precipitated part to obtain a stable gold nanorod-solution;

[0027] (2) ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

A targeted mesoporous molecular imaging probe and a preparation method thereof, the targeted mesoporous molecular imaging probe consists of a surface plasmon resonance core layer at least comprising gold nanorods I, gold nanorods II, and substrate nanoparticles, and a fluorescent Molecules, thiol biomolecules, and polystyrene sulfonate joints are composed of two outer cladding layers, wherein the gold nanorods 1 and 2 are conjugated to the base nanoparticles to form a surface plasmon resonance core layer , the distance between the gold nanorod 1 and the gold nanorod 2 satisfies that the gold nanorod 1 and the gold nanorod 2 are combined with the thiol biomolecules outside the core layer, the fluorescent molecules are combined with the thiol biomolecules through the amide covalent bond, and the polystyrenesulfonic acid The salt is directly bridged to the substrate. The invention also includes the preparation method of the targeting mesoporous molecular imaging probe. The present invention can be blue-shifted or red-shifted by surface excitation, which can match the luminous characteristics of fluorescent tissue, so that the luminous intensity can be increased by 8 to 10 orders of magnitude. The present invention has very high fluorescent characteristics and can be used for the diagnosis of tumor fluorescence imaging, especially Tumor detection and diagnosis in dark field deep in tissue cells.

Description

technical field [0001] The invention relates to a targeting mesoporous molecular imaging probe and a preparation method thereof, in particular to a targeting mesoporous molecular imaging probe based on surface plasmon resonance gold nanorods and a preparation method thereof. Background technique [0002] Visible light imaging has many advantages over nuclear magnetic resonance imaging, such as easy operation, intuitive results, fast measurement, no radiation to the human body, low environmental requirements, and low cost. Therefore, the application of visible light imaging technology to clinical medical diagnosis has become the current An important branch of medical imaging. [0003] At present, one of the main reasons limiting the clinical application of visible light imaging technology is the lack of suitable fluorescent probes for human body. At the same time, high contrast is also the main technical bottleneck that plagues fluorescent probes. For example, the prior art ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64B82Y40/00
Inventor 杨立峰张希仁王亚非周鹰王雅馨
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com