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Applications of natamycin in killing of ichthyophthirius multifiliis and cryptocaryon irritans

A technology for stimulating Cryptonucleus and natamycin, which is applied in the directions of medical preparations containing active ingredients, organic active ingredients, anti-infectives, etc. , drug residues and other problems, to achieve the effect of significant killing effect, good dissolution effect and less residue.

Active Publication Date: 2015-07-22
ZHEJIANG INST OF FRESH WATER FISHERIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most effective drugs to treat these two parasites are mercurous nitrate and malachite green, and these two drugs have carcinogenic effects, so they have been banned
With the prohibition of these two drugs, formaldehyde, copper sulfate, potassium permanganate, bronopol, etc. are mainly used for the prevention and treatment of these two parasites at home and abroad at present, but these drugs have no effect on the small melon worm and Cryptocaryon irritant. Significant curative effect, while long-term use has brought problems such as drug residues, environmental pollution, drug resistance, etc., so there is an urgent need for drugs with specific effects on these two parasites

Method used

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  • Applications of natamycin in killing of ichthyophthirius multifiliis and cryptocaryon irritans
  • Applications of natamycin in killing of ichthyophthirius multifiliis and cryptocaryon irritans
  • Applications of natamycin in killing of ichthyophthirius multifiliis and cryptocaryon irritans

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Weigh 5g of natamycin, stir and dissolve in 10g of dimethyl sulfoxide, weigh 5g of surfactant Tween-20, and 80g of solvent water, mix and stir evenly to obtain the control agent.

Embodiment 2

[0027] Weigh 10g of natamycin, stir and dissolve in 20g of glacial acetic acid, weigh 10g of surfactant Tween-20, and 60g of solvent water, mix and stir evenly to obtain the control agent.

Embodiment 3

[0029] Weigh 15g of natamycin, stir and dissolve in 20g of N,N-dimethylformamide, weigh 10g of surfactant Tween-80, and 55g of solvent water, mix and stir evenly to obtain the control agent.

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PUM

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Abstract

The invention belongs to the technical field of chemical product uses, and discloses a prevention and control agent for killing ichthyophthirius multifiliis and cryptocaryon irritans outside aquatic animal bodies, wherein the prevention and control agent comprises, by weight, 5-25% of natamycin, 5-10% of a surfactant, 10-20% of a dissolution agent, and the balance of a solvent. According to the present invention, the natamycin is used, such that advantages of low toxicity, no toxicity on aquatic animals, and less residue are provided; the specific dissolution agent and the specific solvent are utilized, such that the dissolving effect is good, and the dissolution agent can help the entering of the prevention and control agent into the body so as to provide the significant ichthyophthirius multifiliis killing effect; and the prevention and control agent has characteristics of simple preparation, easy use, and low production cost.

Description

[0001] Application of natamycin in killing melon worm and stimulating Cryptocaryonia. technical field [0002] The invention belongs to the technical field of application of chemical products, and specifically relates to the application of natamycin in killing melon worms and stimulating Cryptocaryonia. technical background [0003] Natamycin (Natamycin) is a natural antifungal compound produced by Streptomyces fermentation. It belongs to polyene macrolides. The production of can be widely used in food preservation and antifungal treatment. Its structural formula is: [0004] [0005] Natamycin, the molecular formula is C 33 h 47 NO 13 , Light yellow or light brown powder, melting point is 280°C, slightly soluble in water, hardly soluble in most organic solvents. It relies on its lactone ring structure to interact with sterol compounds on the fungal cell membrane to form antibiotic-sterol compounds, thereby destroying the structure of the fungal cytoplasmic membrane....

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P33/14
Inventor 姚嘉赟沈锦玉尹文林袁雪梅蔺凌云徐洋潘晓艺郝贵杰
Owner ZHEJIANG INST OF FRESH WATER FISHERIES
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