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Pharmaceutical use of guaiol

A technology of guaiacol and drugs, which is applied in the field of medicine, can solve the problems that there are no research reports on the application of guaiacol, and achieve the effect of inhibiting tumor growth

Inactive Publication Date: 2015-07-29
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research report on the application of guaiacol in the treatment of malignant tumors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Investigation of the effect of guaiacol on the growth of lung adenocarcinoma cell A549

[0028] The lung adenocarcinoma cells A549 were co-cultured with different concentrations of guaiacol for 24, 48 and 72 hours, and the number of living cells was detected by thiazolium blue (MTT) assay.

[0029] Table 1, the inhibitory rate of guaiacol on the growth of A549 cells (%)

[0030]

[0031] figure 1 It reflects the effect of different concentrations of guaiacol on the inhibition rate of lung adenocarcinoma cell A549 under co-cultivation for 24 hours. A, B, C, D, E, F, G, and H in the figure represent the dose of guaiacol in sequence 0, 0.625, 1.25, 2.5, 5.0, 10.0, 20.0, 40.0μM; figure 2 It reflects the effect of different concentrations of guaifeneol on the growth inhibition rate of A549 cells at different co-cultivation times. The A curve in the figure represents the co-cultivation for 24 hours, the B curve represents the co-cultivation for 48 hours, and ...

Embodiment 2

[0033] Example 2: Investigation of the effect of guaiacol on the growth of colorectal cancer cells HCT-8

[0034] The colorectal cancer cells HCT-8 were co-incubated with different concentrations of guaiacol for 24 and 48 hours, and the number of living cells was detected by thiazolium blue (MTT) assay.

[0035] Table 2, the inhibition rate of guaiacol on the growth of HCT-8 cells (%)

[0036]

[0037] image 3 It reflects the effect of different concentrations of guaiacol on the inhibition rate of colorectal cancer cells HCT-8 under co-cultivation for 24 hours. A, B, C, D, E, F, G, and H in the figure represent the dose of guaiacol in turn 0, 0.625, 1.25, 2.5, 5.0, 10.0, 20.0, 40.0μM; Figure 4 It reflects the effect of different concentrations of guaifeneol on the growth inhibition rate of colorectal cancer cell HCT-8 at different co-cultivation times. The A curve in the figure represents the co-cultivation for 24 hours, and the B curve represents the co-cultivation for...

Embodiment 3

[0039] Example 3: Investigation of the effect of guaiacol on the growth of non-small cell lung cancer cell H1975

[0040] Non-small cell lung cancer cells H1975 were co-cultured with different concentrations of guaiacol for 24 hours, and the number of living cells was detected by thiazolium blue (MTT) assay.

[0041] Table 3, the inhibition rate of guaiacol on the growth of H1975 cells (%)

[0042]

[0043] Figure 5 It reflects the effect of different concentrations of guaiacol on the inhibition rate of non-small cell lung cancer H1975 under co-cultivation for 24 hours.

[0044] Combining Table 3 and Figure 5It can be seen that with the increase of the dose of guaiacol, the inhibitory effect of guaiacol on non-small cell lung cancer cell H1975 is more significant, with obvious dose dependence.

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Abstract

The present invention discloses a pharmaceutical use of guaiol, wherein the use is application of guaiol as an active ingredient or the only active ingredient to prepare anti-tumor treatment pharmaceutical preparation. The research results of the present invention show that: the guaiol can significantly inhibit tumor cell viability and proliferation and does not inhibit normal immune cell survival in vitro and can significantly inhibit tumor growth in vivo, such that the guaiol is the active substance expected to be developed into the low-toxicity and high-efficiency anti-tumor pharmaceutical preparation, and has pharmaceutical prospects.

Description

technical field [0001] The invention relates to a medicinal application of guaiacol, in particular to the application of guaiacol in the preparation of antitumor drug preparations, and belongs to the technical field of medicine. Background technique [0002] With the smooth implementation of the Human Genome and Cancer Anatomy Genome Project, people have a deeper understanding and understanding of the molecular mechanisms of the occurrence, development and outcome of malignant tumors, and the diagnosis and treatment of malignant tumors have been significantly improved. The morbidity and mortality of cancer patients remain high. "2012 China Cancer Registration Annual Report": There are about 3.12 million new cancer cases in China every year, an average of 8,550 people per day, and 6 people are diagnosed with cancer every minute across the country. The incidence of malignant tumors nationwide is 87.07 / 100,000 for the age group of 35 to 39 years old, and almost doubles to 154....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/045A61P35/00
Inventor 朱诗国龚陈媛祝晓雯骆莹滨
Owner SHANGHAI UNIV OF T C M