Compositions and methods for treatment of hyperglycemia
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A composition and compound technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, blood diseases, etc.
Inactive Publication Date: 2015-07-29
CELLIXBIO PTE LTD
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Despite strong experimental evidence that oxidative stress can determine the onset and course of advanced diabetic complications, there is still controversy as to whether elevated oxidative stress in hyperglycemia is merely an association rather than a causation
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[0154] The comparison of the compound of formula I (1-3) and eicosapentaenoic acid (EPA) solubility in water
[0155]Measurement of aqueous solubility of test compounds is accomplished by methods well known to those skilled in the art. Specifically, distilled water was added several times in small amounts to a weighed amount of the test compound of the example compound formula I (1-3) until a clear solution was obtained. Measure the total volume of the solution. Water solubility was calculated by dividing the weight of the salt in milligrams (mg) by the volume of the solution in mL. When measured by the above method, the water solubility of the compound of formula I (1-3) was determined to be 68.6 mg / ml. Likewise, the water solubility of EPA was found to be <0.2 mg / mL. Thus, compounds of formula I (1-3) are at least 260 times more water soluble than EPA itself. This clearly demonstrates the unexpectedly high bioavailability of the composition of the invention. When a high...
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Abstract
The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of hyperglycemia may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.
Description
[0001] priority [0002] This application claims the benefit of Indian Provisional Patent Application No. 1811 / CHE / 2012, filed May 8, 2012, the entire disclosure of which is relied upon for all purposes and is incorporated by reference in its entirety In this application. technical field [0003] The present disclosure relates generally to compounds and compositions useful in the treatment of hyperglycemia, diabetes and insulin resistance. More specifically, the present invention relates to the treatment of a subject with a pharmaceutically acceptable dose of a compound, crystal, ester, stereoisomer, enantiomer, salt, hydrate, prodrug, or mixture thereof. Background technique [0004] Multiple metabolic syndromes are defined as multiple severe metabolic disorders that increase the risk of cardiovascular disease (CVD), still the most important cause of death in the Western world, and type 2 diabetes. Multiple metabolic syndrome, also known as insulin resistance syndrome, sy...
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