Cefquinome sulfate lung-targeted liposome preparation and preparation method thereof
A technology of cefquinome sulfate and liposome preparation, which is applied in the field of medicine, can solve the problems of high preparation cost, damage to the injection site, and increased drug resistance of toxic and side effects, and achieve reliable curative effect and stable quality
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[0030] Example one:
[0031] A cefquinome sulfate lung-targeted liposome preparation is composed of the following components by weight:
[0032]
[0033] Specific steps are as follows:
[0034] (1) Precisely weigh 150g of egg yolk lecithin, 30g of cholesterol, and 0.02g of PG in 300ml of chloroform-methanol solution, and place them in a reaction vessel. The organic solvents will be removed by rotary evaporation under reduced pressure in a water bath at 35°C to form a uniform and transparent surface on the vessel wall. 的膜;
[0035] (2) Add 1g D-mannose and 20g cefquinome sulfate to 500ml water for injection, add 2mol / L sodium hydroxide solution until the drug is dissolved, add 0.2mol / L phosphate buffer to adjust the pH to 6.5, add the solution Go to the reaction vessel containing liposome film obtained in step 1), stir and emulsify and hydrate for 30 minutes at 25°C under normal pressure at a speed of 300r / min, then heat up to 30°C and stir and emulsify for 1 hour to obtain a liposome ...
Example Embodiment
[0038] Embodiment two:
[0039] A cefquinome sulfate lung-targeted liposome preparation is composed of the following components by weight:
[0040]
[0041] Specific steps are as follows:
[0042] (1) Precisely weigh 180g egg yolk lecithin, 50g cholesterol, and 0.05g BHA in 360ml chloroform-methanol solution, place them in a reaction vessel, and remove the organic solvents by rotary evaporation under reduced pressure in a water bath at 35°C, forming a uniform and transparent surface on the vessel wall 的膜;
[0043] (2) Add 2g D-mannose and 25g cefquinome sulfate to 500ml water for injection, add 2mol / L sodium hydroxide solution until the drug is dissolved, add 0.2mol / L phosphate buffer to adjust the pH to 6.5, add the solution Go to the reaction vessel containing liposome film obtained in step 1), stir and emulsify and hydrate for 30 minutes at 25°C under normal pressure at a speed of 300r / min, then heat up to 30°C and stir and emulsify for 1 hour to obtain a liposome solution. 8g of ...
Example Embodiment
[0046] Example three
[0047] A cefquinome sulfate lung-targeted liposome preparation is composed of the following components by weight:
[0048]
[0049]
[0050] Specific steps are as follows:
[0051] (1) Precisely weigh 20Kg egg yolk lecithin, 6Kg cholesterol, and 10g BHT in 40L chloroform-methanol solution, and place them in a reaction vessel. The organic solvent is removed by rotary evaporation under reduced pressure in a water bath at 35°C, forming a uniform and transparent surface on the wall of the vessel. film;
[0052] (2) Add 300g mannitol and 3Kg cefquinome sulfate to 50L water for injection, add 2mol / L sodium hydroxide solution until the drug is dissolved, add 0.2mol / L phosphate buffer to adjust the pH to 6.5, add the solution to the step 1) In the resulting reaction vessel containing the liposome film, stir emulsify and hydrate for 30 minutes at 25°C under normal pressure at a speed of 300r / min, and then heat to 30°C, stir and emulsify for 1 hour, to obtain liposome so...
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