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A kind of method for detecting glycosides

A detection method and drug technology, applied in the field of pharmaceuticals, can solve the problems of no preparation quality detection method and inability to effectively guarantee product quality

Active Publication Date: 2016-07-13
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The Fugan drug described in the present invention has no preparation quality detection method in the prior art, and the product quality cannot be effectively guaranteed in production and use. Therefore, in order to ensure the quality of the Fugan drug and the clinical efficacy and safety of the drug, a set of simple and reliable methods is provided. The quality inspection method is very important

Method used

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  • A kind of method for detecting glycosides
  • A kind of method for detecting glycosides
  • A kind of method for detecting glycosides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0323] Example 1: Determination of Monoester Alkaloid Content in Fugan Granules

[0324] 1) Preparation of granules: Take 6 kg of aconite and 1 kg of licorice, add water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1 hour, combine twice The decoction is filtered, concentrated, dried under reduced pressure, crushed, an appropriate amount of dextrin is added, mixed evenly, granulated by wet method, dried, and granulated to obtain granules of the medicine with sweetener.

[0325] 2) inspection

[0326] Get sample, check according to quality standard described in the present invention, test result sees the following table:

[0327] Table 38 Test results

[0328]

[0329]

Embodiment 2

[0330] Embodiment 2: Determination of monoester type alkaloid content of Fugan Granules

[0331] 1) Preparation of granules: Take 18kg of aconite and 9kg of licorice, add water to decoct twice, add 10 times the amount of water for the first time, decoct for 1.5 hours, add 8 times the amount of water for the second time, decoct for 1 hour, combine twice The decoction is filtered, concentrated, dried under reduced pressure, crushed, an appropriate amount of dextrin is added, mixed evenly, granulated by wet method, dried, and granulated to obtain granules of the medicine with sweetener.

[0332] 2) inspection

[0333] Get sample, check according to quality standard described in the present invention, test result sees the following table:

[0334] Table 39 Test results

[0335]

[0336]

Embodiment 3

[0337] Embodiment 3: Determination of monoester type alkaloid content of Fugan Granules

[0338] 1) Preparation of granules: Take 10kg of aconite and 5kg of licorice, add water to decoct three times, add 8 times the amount of water for the first time, decoct for 1.5 hours, add 8 times the amount of water for the second time, decoct for 1 hour, and add 6 times the amount of water, decocted for 1 hour, combined three decoctions, filtered, concentrated, dried under reduced pressure, pulverized, added an appropriate amount of dextrin, mixed evenly, wet granulated, dried, and granulated to obtain granules of Fugan drug .

[0339] 2) inspection

[0340] Get sample, check according to quality standard described in the present invention, test result sees the following table:

[0341] Table 40 Test results

[0342]

[0343]

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Abstract

The invention provides a method for the quality detection of a monkshood-radix glycyrrhizae medicament. The method is characterized in that a chromatographic column taking a polar diethyl ether connected phenyl bonded silica gel as a filler is adopted for identifying and determining the content of monkshood, so that the separating degree, peak shape and tailing factor of a target component are significantly improved; a thin-layer chromatography is adopted for identifying radix glycyrrhizae; high performance liquid chromatography is adopted for controlling the content of diester-type alkaloids; and related methodology validation and example inspection show that according to the method provided by the invention, the monkshood-radix glycyrrhizae medicament can be simply and accurately identified, the content of diester-type alkaloids can be controlled, and the contents of monkshood and radix glycyrrhizae can be detected, so that the product quality can be effectively guaranteed in the processes of production and use, and then the curative effect of the medicament is ensured.

Description

technical field [0001] The invention relates to a method for detecting the quality of Fugan medicine, which belongs to the technical field of medicines. technical background [0002] Chinese invention patent (ZL201210536161.3) is a medicine for treating allergic rhinitis and bronchial asthma. It has a good curative effect on bronchial asthma. [0003] Allergic rhinitis and bronchial asthma are respiratory diseases closely related to type Ⅰ allergy. It is a frequently-occurring and intractable disease, and its prevalence is increasing year by year. The existing drugs for the treatment of allergic rhinitis mainly include antihistamines, glucocorticoids, anti-leukotriene drugs, anticholinergic drugs, and adrenaline-mimetic drugs, etc., which are mainly administered through the nasal cavity, and long-term use is prone to side effects and Drug resistance, high recurrence rate after healing, and poor long-term curative effect. In addition, desensitization immunotherapy is limi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/90
Inventor 石红艳刘金磊王丽刘圣梅张为胜
Owner JINAN KANGZHONG PHARMA TECH DEV
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