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Magnetic acrylamide hydrogel and preparation method thereof

A technology of acrylamide and hydrogel, applied in the field of magnetic acrylamide hydrogel and its preparation, can solve the problems such as the unseen reports of particle method, and achieve the improvement of biocompatibility, clarity, good size and good size. control effect

Inactive Publication Date: 2015-08-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, P(NtBAM-co-AAc) is used as the coating material of magnetic hydrogels, and only FeSO 4 ·7H 2 O in situ redox synthesis of Fe in NtBAM-based hydrogels 3 o 4 The particle method has not been reported yet

Method used

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  • Magnetic acrylamide hydrogel and preparation method thereof
  • Magnetic acrylamide hydrogel and preparation method thereof
  • Magnetic acrylamide hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Dissolve 0.7282g N-isopropylacrylamide NtBAM, 0.0467g acrylic acid AAc, 0.0212g N,N'-methylenebisacrylamide and 0.0402g sodium lauryl sulfate in 90g deionized water, and Bubble N at room temperature 2 Deoxygenation, magnetic stirring for 120min;

[0037] (2) The reaction temperature rises to 60°C, under N 2 Insulate the above solution under protection for 40min;

[0038] (3) then preparation mass concentration is the ammonium persulfate solution of 0.6%, gets 9.9987g and adds in the above-mentioned solution, keeps N 2 atmosphere, continue to react for 3h;

[0039] (4) Soak the obtained reactant in deionized water and dialyze for 5 days, change the water twice a day, remove the residual reaction raw materials and electrolyte in the reaction system, and use a dialysis bag with a molecular weight cut-off of 8000-14000 to obtain the copolymerization of NtBAM and AAc Hydrogels, numbered a, such as figure 1 shown.

Embodiment 2

[0041] (1) Take 0.7259g N-isopropylacrylamide NtBAM, 0.2740g acrylic acid AAc, 0.0302g N,N'-methylenebisacrylamide and 0.0205g sodium lauryl sulfate dissolved in 90g deionized water, and Bubble N at room temperature 2 Deoxygenation, magnetic stirring for 120min;

[0042] (2) The reaction temperature rises to 60°C, under N 2 Insulate the above solution under protection for 40min;

[0043] (3) then prepare the ammonium persulfate solution that mass concentration is 0.6%, get 10.0087g and add in the above-mentioned solution, keep N 2 atmosphere, continue to react for 3h;

[0044] (4) Soak the obtained reactant in deionized water and dialyze for 5 days, change the water twice a day, remove the residual reaction raw materials and electrolyte in the reaction system, and use a dialysis bag with a molecular weight cut-off of 8000-14000 to obtain the copolymerization of NtBAM and AAc Hydrogel, numbered b, such as figure 1 shown.

Embodiment 3

[0046] (1) Take 50mL of the product in Example 1, use NaOH to adjust the pH to 6.42, and 0.1391g of FeSO 4 ·7H 2 O mixed, at room temperature, N 2 Stir in the atmosphere overnight, then use the above-mentioned dialysis bag for dialysis for 2 hours;

[0047] (2) Continue at room temperature, N 2 After stirring in the atmosphere for 2h, add 0.054gNaNO 2 ;

[0048] (3) Keep stirring for 10 minutes, add 5 mL of ammonia water using a syringe, and continue to react for 3 hours;

[0049] (4) The obtained reactant was soaked in deionized water and dialyzed for 3 days, and the water was changed twice a day, using the above-mentioned dialysis bag. The in situ synthesized magnetic hydrogel is obtained, numbered c, such as figure 1 shown.

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Abstract

The invention relates to a magnetic acrylamide hydrogel and a preparation method thereof. The hydrogel is obtained by coating poly(tert-butyl acrylamide-co-crylic acid)P(NtBAM-co-AAc) with Fe3O4 particles. The preparation method comprises the steps of (1) dissolving monomer N- tert-butyl acrylamide, monomer crylic acid, emulsifier and a crosslinking agent into deionized water, stirring at 15-40 DEG C in nitrogen atmosphere, then rising temperature to 60-90 DEG C, preserving the temperature, then adding an initiator, reacting for 0.5-10 hours, and dialyzing to obtain copoly nano-hydrogel; (2) adjusting pH of the copoly nano-hydrogel, adding FeSO4.7H2O, stirring, dialyzing, adding NaNO2 and NH3.H2O, and dialyzing after reaction to obtain the hydrogel. The magnetic acrylamide hydrogel has better size controllability, monodispersity and excellent magnetism compared with traditional Fe3O4-coated particle compound. The preparation method is simple in process and environment-friendly.

Description

technical field [0001] The invention belongs to the field of hydrogel and its preparation, in particular to a magnetic acrylamide hydrogel and its preparation method. Background technique [0002] Magnetic hydrogels have the dual advantages of hydrogel polymers and inorganic magnetic particles, so they have great potential in the fields of biomedicine, nonlinear optical materials, materials science, environmental protection, bioengineering, electrochemical displays, molecular devices, electromagnetic shielding, microwave absorption, etc. widely used. In particular, magnetic particles have been studied and applied to magnetic hyperthermia, drug delivery, magnetic resonance imaging, etc. in biomedicine. 3 o 4 The surface is hydrophobic, so it can be coated with a hydrophilic hydrogel for in vivo application. Poly N-isopropylacrylamide (PNIPA) is the most typical hydrogel, and it is also the most widely studied and applied hydrogel. Its volume phase transition temperature (V...

Claims

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Application Information

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IPC IPC(8): C08L33/24C08K3/22C08F220/54C08F220/06C08F222/38
Inventor 鲁希华马天泽赵迪李雪婷刘维伊
Owner DONGHUA UNIV
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