Magnetic acrylamide hydrogel and preparation method thereof

A technology of acrylamide and hydrogel, applied in the field of magnetic acrylamide hydrogel and its preparation, can solve the problems such as the unseen reports of particle method, and achieve the improvement of biocompatibility, clarity, good size and good size. control effect

Inactive Publication Date: 2015-08-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, P(NtBAM-co-AAc) is used as the coating material of magnetic hydrogels, and only FeSO 4 ·7H

Method used

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  • Magnetic acrylamide hydrogel and preparation method thereof
  • Magnetic acrylamide hydrogel and preparation method thereof
  • Magnetic acrylamide hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0035] Example 1

[0036] (1) Dissolve 0.7282g N-isopropylacrylamide NtBAM, 0.0467g acrylic acid AAc, 0.0212g N,N'-methylenebisacrylamide and 0.0402g sodium lauryl sulfate in 90g deionized water, and Blow in N at room temperature 2 Deoxygenation, magnetic stirring for 120min;

[0037] (2) The reaction temperature rises to 60℃, at N 2 Keep the above solution under protection for 40 minutes;

[0038] (3) Then prepare an ammonium persulfate solution with a mass concentration of 0.6%, add 9.987g to the above solution, and keep N 2 Atmosphere, continue to react for 3h;

[0039] (4) Then immerse the obtained reactant in deionized water for 5 days for dialysis. Change the water twice a day to remove residual reaction materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000~14000, which is the copolymerization of NtBAM and AAc. Hydrogel, numbered a, such as figure 1 Shown.

Example Embodiment

[0040] Example 2

[0041] (1) Dissolve 0.7259g of N-isopropylacrylamide NtBAM, 0.2740g of acrylic acid AAc, 0.0302g of N,N'-methylenebisacrylamide and 0.0205g of sodium lauryl sulfate in 90g of deionized water, and Blow in N at room temperature 2 Deoxygenation, magnetic stirring for 120min;

[0042] (2) The reaction temperature rises to 60℃, at N 2 Keep the above solution under protection for 40 minutes;

[0043] (3) Then prepare an ammonium persulfate solution with a mass concentration of 0.6%, add 10.0087g to the above solution, and keep N 2 Atmosphere, continue to react for 3h;

[0044] (4) Then immerse the obtained reactant in deionized water for 5 days for dialysis. Change the water twice a day to remove residual reaction materials and electrolytes in the reaction system. The molecular weight cut-off of the dialysis bag used is 8000~14000, which is the copolymerization of NtBAM and AAc. Hydrogel, numbered b, such as figure 1 Shown.

Example Embodiment

[0045] Example 3

[0046] (1) Take 50 mL of the product in Example 1, use NaOH to adjust the pH to 6.42, and 0.1391 g of FeSO 4 ·7H 2 O mixed, at room temperature, N 2 Stir in the atmosphere overnight, then use the above dialysis bag to dialyze for 2h;

[0047] (2) Continue at room temperature, N 2 After stirring for 2h in the atmosphere, add 0.054g NaNO 2 ;

[0048] (3) Keep stirring for 10 minutes, use a syringe to add 5 mL ammonia water, and continue the reaction for 3 hours;

[0049] (4) The obtained reactant was immersed in deionized water for dialysis for 3 days, the water was changed twice a day, and the dialysis bag was used. The in-situ synthesized magnetic hydrogel is obtained, numbered as c, such as figure 1 Shown.

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Abstract

The invention relates to a magnetic acrylamide hydrogel and a preparation method thereof. The hydrogel is obtained by coating poly(tert-butyl acrylamide-co-crylic acid)P(NtBAM-co-AAc) with Fe3O4 particles. The preparation method comprises the steps of (1) dissolving monomer N- tert-butyl acrylamide, monomer crylic acid, emulsifier and a crosslinking agent into deionized water, stirring at 15-40 DEG C in nitrogen atmosphere, then rising temperature to 60-90 DEG C, preserving the temperature, then adding an initiator, reacting for 0.5-10 hours, and dialyzing to obtain copoly nano-hydrogel; (2) adjusting pH of the copoly nano-hydrogel, adding FeSO4.7H2O, stirring, dialyzing, adding NaNO2 and NH3.H2O, and dialyzing after reaction to obtain the hydrogel. The magnetic acrylamide hydrogel has better size controllability, monodispersity and excellent magnetism compared with traditional Fe3O4-coated particle compound. The preparation method is simple in process and environment-friendly.

Description

technical field [0001] The invention belongs to the field of hydrogel and its preparation, in particular to a magnetic acrylamide hydrogel and its preparation method. Background technique [0002] Magnetic hydrogels have the dual advantages of hydrogel polymers and inorganic magnetic particles, so they have great potential in the fields of biomedicine, nonlinear optical materials, materials science, environmental protection, bioengineering, electrochemical displays, molecular devices, electromagnetic shielding, microwave absorption, etc. widely used. In particular, magnetic particles have been studied and applied to magnetic hyperthermia, drug delivery, magnetic resonance imaging, etc. in biomedicine. 3 o 4 The surface is hydrophobic, so it can be coated with a hydrophilic hydrogel for in vivo application. Poly N-isopropylacrylamide (PNIPA) is the most typical hydrogel, and it is also the most widely studied and applied hydrogel. Its volume phase transition temperature (V...

Claims

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Application Information

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IPC IPC(8): C08L33/24C08K3/22C08F220/54C08F220/06C08F222/38
Inventor 鲁希华马天泽赵迪李雪婷刘维伊
Owner DONGHUA UNIV
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