Application of traditional Chinese medicine composition to preparation of acute renal failure treatment drug

A technique for acute renal failure and composition, applied in the field of application of traditional Chinese medicine composition in the preparation of medicines for treating acute renal failure

Inactive Publication Date: 2015-09-09
周耀忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few clinical drugs that have obvious effects on improving renal blood perfusion disorder and reducing renal tissue damage

Method used

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  • Application of traditional Chinese medicine composition to preparation of acute renal failure treatment drug
  • Application of traditional Chinese medicine composition to preparation of acute renal failure treatment drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: get ancient sheep vine 15g, rag grass 12g, periwinkle 18g, forsythia 12g, iron horsewhip 20g, scorpion maple 18g, horse wind 15g, snake lotus 12g, two-leaf Maihe grass 20g, add water Decocting twice, the first time adding water is 10 times the weight of the medicinal material, decocting for 2 hours, the second time adding water is 8 times the weight of the medicinal material, decocting for 1 hour, combining the decoction, concentrating, drying, and pulverizing The traditional Chinese medicine composition granules are obtained, and the concentration conditions are as follows: 0.07 MPa, 60-70°C, and concentration under reduced pressure until the relative density is 1.30 at 65°C. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s. .

Embodiment 2

[0019] Embodiment 2: Therapeutic effect of Chinese medicine composition on rats with acute renal failure

[0020] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0021] 2. Method: The rat animal model of acute renal failure induced by intramuscular injection of glycerol was used. Select 60 healthy male SD rats of 180~220g, and divide them into 5 groups at random: sham operation group (intramuscular injection of normal saline); model group (intramuscular injection of glycerin); Chinese medicine composition I group (3g crude drug amount / Kg)); Chinese medicine composition II group (6g crude drug amount / Kg)); Chinese medicine composition III group (12g crude drug amount / Kg)), each group of rats injected normal saline or oral Chinese medicine composition into the tail vein immediately after glycerol modeling, 12 And again after 24 hours.

[0022] 3. Observation indicators: 60 rats were put into metabolic cages to collect urine for 24 hours after ...

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PUM

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Abstract

The invention relates to novel pharmaceutical application of a traditional Chinese medicine composition, that is, the application of the traditional Chinese medicine composition to preparation of an acute renal failure treatment drug. The traditional Chinese medicine composition is prepared from 15 parts of root of griffith streptocaulon, 12 parts of stachys kouyangensis, 18 parts of libanotis spodotrichoma, 12 parts of hyperioums sampsonii hance, 20 parts of rhamnus aurea, 18 parts of heteropanax fragrans, 15 parts of herb of laciniate blumea, 12 parts of coriaceous knotweed rhizome and 20 parts of maianthemum bifolium. The application provided by the invention is disclosed for the first time, and can be regarded as a remarkable progress.

Description

technical field [0001] The invention relates to a new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of medicine for treating acute renal failure. Background technique [0002] Acute renal failure (Acute Renal Failure, ARF) is a clinical syndrome caused by a variety of reasons, which can be seen in patients of various clinical departments. It has a high incidence and often brings serious consequences. ) sharp decline in mental function, clinical manifestations of acute oliguria (urine output <400mLPd) or anuria (urine output <100mLPd), obstruction of nitrogen metabolite excretion in the body, rapid azotemia, water and electrolytes, acid-base Balance disorder, and cause the corresponding dysfunction of the system of the whole body. The main factors causing acute renal failure are the sharp reduction of renal blood flow, as well as the oxidative stress and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P13/12
Inventor 周耀忠
Owner 周耀忠
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