Release way and preparation method of novel compound sleeping controlled release preparation

A technology for controlled release preparations and compound recipes, which is applied in the field of pharmaceutical preparations and can solve problems such as slow onset of action and slow drug release.

Inactive Publication Date: 2015-09-16
TAIZHOU OVERSEAS PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the research on sustained and controlled release preparations at home and abroad has been relatively mature. The advantages of sustained and controlled release preparations are that they can maintain the effective concentration of drugs in the body for a long time, reduce adverse drug reactions, and improve patients' compliance with medication. However, slow and controlled release preparations Compared with common preparations, there are also disadvantages, such as slow drug release and slow onset of action, etc.

Method used

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  • Release way and preparation method of novel compound sleeping controlled release preparation
  • Release way and preparation method of novel compound sleeping controlled release preparation
  • Release way and preparation method of novel compound sleeping controlled release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The controlled-release tablet of this embodiment is as figure 1 As shown, it includes an inner tablet and a drug-containing shell, and the inner tablet is a porous tablet with a slow-release layer.

[0032] The composition and content of the controlled-release tablets are as follows: based on 1000 tablets, each tablet weighs 450 mg.

[0033] Drug-containing shell:

[0034]

[0035] Perforated inner sheet:

[0036]

[0037] Preparation:

[0038] 1. Weigh the raw and auxiliary materials of the inner layer tablet according to the prescription, and mix them thoroughly for later use; select two types of punches, and the diameter of No. 1 punch is smaller than that of No. Ⅱ;

[0039] 2. Use a rotary tablet press, install punch Ⅰ, adjust the filling depth and tablet pressing force of the tablet press, and press the inner tablet. The tablet weight is 150 mg per tablet, and the hardness of the inner tablet is 80 N;

[0040] 3. Use a rotary tablet press, install punch I...

Embodiment 2

[0044] The controlled-release tablet of this embodiment is as figure 1 As shown, it includes an inner tablet and a drug-containing shell, and the inner tablet is a porous tablet with a slow-release layer.

[0045]The composition and content of the controlled-release tablets are as follows: based on 1000 tablets, each tablet weighs 450 mg.

[0046] Drug-containing shell:

[0047]

[0048] Perforated inner sheet:

[0049]

[0050] Preparation:

[0051] 1. Weigh the raw and auxiliary materials of the inner layer tablet according to the prescription, and mix them thoroughly for later use; select two types of punches, and the diameter of No. 1 punch is smaller than that of No. 2;

[0052] 2. Use a rotary tablet press, install punch Ⅰ, adjust the filling depth and tablet pressing force of the tablet press, and press the inner tablet. The tablet weight is 150 mg per tablet, and the hardness of the inner tablet is 80 N;

[0053] 3. Use a rotary tablet press, install punch II...

Embodiment 3

[0057] The controlled-release tablet of this embodiment is as figure 1 As shown, it includes an inner tablet and a drug-containing shell, and the inner tablet is a porous tablet with a slow-release layer.

[0058] The composition and content of the controlled-release tablets are as follows: based on 1000 tablets, each tablet weighs 450 mg.

[0059] Drug-containing shell:

[0060]

[0061] Perforated inner sheet:

[0062]

[0063] Preparation:

[0064] 1. Weigh the raw and auxiliary materials of the inner layer tablet according to the prescription, and mix them thoroughly for later use; select two types of punches, and the diameter of No. 1 punch is smaller than that of No. Ⅱ;

[0065] 2. Use a rotary tablet press, install punch Ⅰ, adjust the filling depth and tablet pressing force of the tablet press, and press the inner tablet. The tablet weight is 150 mg per tablet, and the hardness of the inner tablet is 80 N;

[0066] 3. Use a rotary tablet press, install punch I...

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Abstract

The invention discloses a novel compound sleeping pill, including a quick release drug release layer and a sustained and controlled release drug release layer. The two layers respectively contain a same sleeping pill or different sleeping pills, and the double layer tablet shows 15 min of rapid dissolution and up to 4 hours of slow dissolution after 2 h. By taking the double layer tablet, the effects of fast sleeping and early awakening prevention of a patient can be achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to the release mode, composition and preparation method of a novel compound hypnotic controlled-release preparation. Background technique [0002] According to the World Health Organization survey of 25,916 patients in primary care in 15 regions in 14 countries, it was found that 27% of them had sleep problems. According to reports, the incidence of insomnia in the United States is as high as 32% to 50%, in the United Kingdom it is 10% to 14%, in Japan it is 20%, in France it is 30%, and in China it is also above 30%. Symptoms of insomnia generally manifest as difficulty in falling asleep, shallow sleep, easy to wake up, and early awakening. [0003] Early awakening is a kind of sleep disorder, which is manifested as waking up earlier than the regular wake-up time of one's own sleep and being unable to fall asleep again. Generally, it is 2-3 hours earlier than normal or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/4985A61K31/4375A61K47/36A61P25/20
Inventor 闻晓光范军叶强李伟谊王姝张晨梁
Owner TAIZHOU OVERSEAS PHARMA LTD
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