A traditional Chinese medicine composition for preventing and treating delayed nausea and vomiting caused by chemotherapy and its application

Abstract

The invention discloses a traditional Chinese medicine combination for preventing and treating delayed nausea and vomiting caused by chemotherapy. The traditional Chinese medicine combination comprises, by weight, 20-25 parts of pinellia rhizoma prepared by ginger, 15-20 parts of cassia twigs, 10-15 parts of agastache rugosus, 10-15 parts of fructus amomi, 8-12 parts of fructus evodiae, 4-10 parts of inula flower, 4-6 parts of pericarpium citri reticulatae, 10-16 parts of ginger juice and 1-3 parts of menthol. The traditional Chinese medicine combination has the advantages of being rigorous in composition, easy to prepare, free of stimulus, low in cost, easy to operate and capable of being accepted by patients easily. The traditional Chinese medicine combination is combined with granisetron and dexamethasone for use, can well treat delayed nausea and vomiting and loss of appetite caused by cis-platinum, also can relieve the side effects, like constipation of patient, caused by the usage of the granisetron and dexamethasone, provides a novel way for delayed nausea and vomiting patients, fills the blank of treating the delayed nausea and vomiting through traditional Chinese medicine at home and abroad, and reaches the international leading level.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for preventing and treating delayed nausea and vomiting caused by chemotherapy. Background technique [0002] Delayed nausea and vomiting refers to vomiting that occurs 24 hours after chemotherapy. Usually occurs in 48-72 hours, sometimes as long as 120 hours later. The incidence of delayed nausea and vomiting was 19%-33% and 49%-75% in patients receiving chemotherapy with moderate and high vomiting risk. Cisplatin is a broad-spectrum anti-tumor drug that is currently widely used in clinical practice. It has a high risk of vomiting. 70-80% of patients will have delayed nausea and vomiting. At present, there is a lack of clinically effective drugs to suppress vomiting. The first-generation 5-HT3 receptor antagonist has a control rate of about 28% on delayed nausea and vomiting; the second-generation 5-HT3 receptor antagonist, Pal...

AI Technical Summary

Problems solved by technology

At present, there is a lack of effective anti-vomiting drugs clinically, and the control rate of delayed nausea and vomiting for the first-generation 5-HT3 receptor antagonist is about 28%; the second-generation 5-HT3 receptor antagonist palonosetron and The combined use of dexamethasone has been confirmed by a large number of studies to reduce the incidence of delayed nausea and vomiting. The control rate of delayed nausea and vomiting is 35%-41%, and the incidence of treatment-related adverse reactions is 44%.

The curative effect of continuous medication of 5-HT3 receptor antagonists is not ideal, and its adverse reactions such as constipation and abdominal distension make it difficult for patients to adhere to continuous medication

Glucocorticoids are commonly used drugs in clinical practice. Combined with 5-HT3 receptor antagonists and NK-1 antagonists, they can significantly improve the control rate of chemotherapy nausea and vomiting, and play a role in synergizing the efficacy and raising the emetic threshold. The research of Roscoe et al. further confirmed that Adding dexamethasone to conventional antiemetic treatment can significantly increase the control rate of delayed nausea and vomiting, but dexamethasone often causes moderate to severe insomnia, dyspepsia, upper abdominal discomfort, restlessness, increased appetite, elevated blood sugar, weight gain and Acne and other adverse reactions

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