A kind of human rabies vaccine and preparation method thereof

A technology of rabies vaccine and rabies virus, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, antiviral agents, etc., can solve the problems of long immune response time, low level of persistent immunity, and inability to quickly treat diseases. The effect of long duration, easy availability of equipment, and improvement of immune response time

Active Publication Date: 2018-07-27
NINGBO RONGAN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, the prior art also discloses the use of other types of compound adjuvants, but the immune response time of these rabies vaccines is relatively long, and the level of persistent immunity is also low, and neutralizing antibodies at an effective protective level cannot be produced in time after vaccination, resulting in the inability to quickly Curing disease

Method used

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  • A kind of human rabies vaccine and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0026] The human rabies vaccine consists of the following components: 0.1 mg of zinc hydroxide, 10 μg of lanolin, 10 μg of bacterial lipopolysaccharide and 10 μg of Tween-80 are used as raw materials for each dose of the inactivated rabies virus vaccine.

[0027] Preparation method: Add zinc gluconate into sterile double-distilled water, fully stir and dissolve to obtain zinc gluconate solution. Sodium hydroxide was added into sterile double-distilled water, fully stirred and dissolved to obtain a sodium hydroxide solution. Under sterile conditions, the zinc gluconate solution and the sodium hydroxide solution were filtered and sterilized with a closed membrane filter respectively, and then used for later use. Under medium-speed stirring, slowly drop the sodium hydroxide solution into the zinc gluconate solution, and stir thoroughly to obtain the zinc hydroxide colloid, which is set aside;

[0028] Add lanolin and bacterial lipopolysaccharide respectively into sterile double-...

Embodiment 2

[0031] The human rabies vaccine consists of the following components: 1 mg of zinc hydroxide, 100 μg of lanolin, 100 μg of bacterial lipopolysaccharide, and 100 μg of Tween-80 are used as raw materials for each dose of the inactivated rabies virus vaccine.

[0032] Preparation method: same as Example 1.

Embodiment 3

[0034] The human rabies vaccine consists of the following components: 2 mg of zinc hydroxide, 300 μg of lanolin, 300 μg of bacterial lipopolysaccharide, and 300 μg of Tween-80 are used as raw materials for each dose of the inactivated rabies virus vaccine.

[0035] Preparation method: same as Example 1.

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Abstract

The invention discloses a human rabies vaccine, which is characterized in that it contains raw materials of inactivated rabies virus vaccine and a composite adjuvant, wherein the composite adjuvant is composed of zinc hydroxide colloid, lanolin, bacterial lipopolysaccharide and Tween-80; The raw materials of the rabies virus inactivated vaccine described in the dosage use 0.1-10 mg of zinc hydroxide colloid, 10-1000 μg of lanolin, 10-1000 μg of bacterial lipopolysaccharide, and 10-1000 μg of Tween-8010-1000 μg. Adopting the compound adjuvant of the present invention greatly improves the immune response time, rapidly produces neutralization, and has a longer duration of immunity, and the preparation process is simple, the required equipment is easy to obtain, the industrial production cost is greatly reduced, and the stability of the obtained rabies vaccine is also improved. Greatly improve.

Description

technical field [0001] The invention relates to a human rabies vaccine and a preparation method thereof, in particular to a human rabies vaccine containing a compound adjuvant and a preparation method thereof. Background technique [0002] Rabies is a natural epidemiological disease with a wide geographical distribution. It is prevalent in all continents of the world except Antarctica and Oceania. China is one of the countries with a high incidence of rabies, currently ranking second in the world. The main cause of human rabies is the increase in the number of dogs kept by the public, and the public's lack of awareness of the dangers of rabies, and the failure to take correct wound treatment and vaccination measures for those bitten by dogs are also important factors for the incidence of rabies. [0003] Anti-rabies immunization is one of the successful examples in the history of early immunological preventive medicine. As early as the 1880s, when Pasteur pioneered the use...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/39A61K39/205A61P31/14
Inventor 胡德东
Owner NINGBO RONGAN BIOLOGICAL PHARMA
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