Method for detecting content, dissolution rate and releasing rate of memantine hydrochloride or analogues thereof in medicinal agent

A technology of memantine hydrochloride and release degree, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of high price, inconvenient use, generation of harmful waste gas, etc. Effect
CN104950047AInactive Publication Date: 2015-09-30ZHUHAI UNITED LAB
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHUHAI UNITED LAB
Publication Date
2015-09-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the chemistry field and in particular relates to a method for detecting memantine hydrochloride or analogues thereof in a medicinal agent. A method for detecting the content, the dissolution rate and the releasing rate of memantine hydrochloride or analogues thereof in medicinal agent adopts the liquid chromatogram conditions as follows: a detector is a differential refraction detector, a chromatographic column takes octyl silane bonded silica gel as a filler, and the moving phase is methanol-0.05mol / L monopotassium phosphate solution. The method is rapid, convenient and accurate and has strong operational practicability.
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Description

technical field

[0001] The invention relates to a method for detecting the content, dissolution rate or release rate of memantine hydrochloride-related preparations, belonging to the field of chemical drug analysis. Background technique

[0002] Memantine hydrochloride is an N-formylaspartate receptor (NMDA) antagonist, which can block the pathological increase of glutamate level caused by abnormal nerve function, effectively regulate excitatory transmitters, and slow down the process of neurodegeneration, thereby Improve cognitive function. It is used for the treatment of moderate to severe Alzheimer's dementia (senile dementia), which is clinically characterized by memory loss, cognitive dysfunction, abnormal mental behavior, etc., and is a chronic progressive mental degenerative disease.

[0003] The chemical name of memantine hydrochloride is 1-amino-3,5-dimethylamantadine hydrochloride. Its structural formula is:

[0004]

[0005] There is no conjugated double bon...

Claims

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