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Cyclosporin cream for treating lupus erythematosus or psoriasis and its preparation method and application

A technology for lupus erythematosus and psoriasis, which is applied in the direction of medical preparations containing active ingredients, skin diseases, and cyclic peptide ingredients, and can solve problems such as large toxic and side effects

Active Publication Date: 2019-04-23
惠州市九惠药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, systemic medication has high toxicity and side effects, and topical application of related drugs to treat lupus erythematosus and psoriasis has become a research focus

Method used

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  • Cyclosporin cream for treating lupus erythematosus or psoriasis and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Embodiment 1 cream preparation

[0133] Prepare the components in the following weight ratios:

[0134] Cyclosporin 50g;

[0135] 50g absolute ethanol;

[0136] 1,2 propylene glycol 50g;

[0137] Polyoxyethylene (40) hydrogenated castor oil 200g;

[0138] Medium chain vegetable oil 160g;

[0139] Azone 6g;

[0140] Carbomer 30g;

[0141] Appropriate amount of sodium bicarbonate;

[0142] Camphor 10g;

[0143] Menthol 10g;

[0144] Ethylparaben 2g;

[0145] Urea 10g;

[0146] Add deionized water to 1000g;

[0147] The preparation method of emulsifiable paste comprises the following steps:

[0148] S11. Dissolve component D in ethanol, add 1,2 propylene glycol and mix evenly, add emulsifier, azone and oil phase 1 and mix evenly to obtain mixed components;

[0149] S12. Carbomer is suspended in deionized water, urea and ethylparaben are added, and the pH value is adjusted to 7.0 with sodium bicarbonate to obtain component B;

[0150] S13. Mix menthol and camp...

Embodiment 2

[0152] Embodiment 2 cream preparation

[0153] Prepare the components in the following weight ratios:

[0154] Cyclosporin 10g;

[0155] 50g absolute ethanol;

[0156] 1,2 propylene glycol 50g;

[0157] Poloxamer 188 200g;

[0158] 160g soybean oil;

[0159] Azone 6g;

[0160] Carbomer 30g;

[0161] Appropriate amount of sodium bicarbonate;

[0162] Camphor 10g;

[0163] Menthol 10g;

[0164] Ethylparaben 2g;

[0165] Urea 10g;

[0166] Add deionized water to 1000g;

[0167] The preparation method is the same as Example 1.

Embodiment 3

[0168] Embodiment 3 cream preparation

[0169] Prepare the components in the following weight ratios:

[0170] Cyclosporin 100g;

[0171] 50g absolute ethanol;

[0172] 1,2 propylene glycol 50g;

[0173] Polyoxyethylene Stearate 380g;

[0174] Oleic acid 160g;

[0175] Azone 6g;

[0176] Carbomer 30g;

[0177] Appropriate amount of sodium bicarbonate;

[0178] Camphor 10g;

[0179] Menthol 10g;

[0180] Ethylparaben 2g;

[0181] Urea 10g;

[0182] Add deionized water to 1000g;

[0183] The preparation method is the same as Example 1.

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Abstract

The invention discloses cyclosporine cream for treating lupus erythematosus or psoriasis, a method for manufacturing the cyclosporine cream and application thereof. The cyclosporine cream, the method and the application have the advantages that scientific compatibility of emulsifiers and oil phases is determined, accordingly, high skin transmission of cyclosporine can be guaranteed, the cyclosporine and dexamethasone acetate are jointly applied to manufacture the cream, the cream can directly act at affected parts, synergistic effects of immune inhibition and anti-inflammation pharmacological mechanisms of the cyclosporine and the dexamethasone acetate can be realized, excellent effects for treating skin symptoms of the lupus erythematosus and the psoriasis can be realized, and the cyclosporine cream is safe and effective when locally applied; the method for manufacturing the cream is simple and feasible and is easy to popularize, and the cream can be manufactured under mild conditions.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a cyclosporine cream for treating lupus erythematosus or psoriasis, a preparation method and application thereof. Background technique [0002] Lupus erythematosus (LE) is a typical autoimmune connective tissue disease, which is more common in women aged 15-40. Lupus erythematosus is a disease spectrum disease, which can be divided into discoid lupus erythematosus (DLE), subacute cutaneous lupus erythematosus (SCLE), systemic lupus erythematosus (SLE), deep-seated lupus erythematosus (LEP), neonatal Lupus erythematosus (NLE), drug-induced lupus erythematosus (DIL) and other subtypes. The treatment principle of lupus erythematosus is anti-inflammatory therapy to eliminate inflammation and correct pathological process, using immunosuppressive or promoting drugs for immune regulation. [0003] Psoriasis, commonly known as psoriasis, is a chronic inflammatory skin disease with a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/13A61K9/06A61P17/06A61P37/02A61P19/04A61K31/573
Inventor 黄辉球
Owner 惠州市九惠药业有限公司
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