Pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography

Abstract

The present invention provides an innovative pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography, wherein the attached experiment spectrogram shows that the detector further has the excellent function of multi-use-in-one-machine in liquid chromatography. According to the pulse ion multifunctional detector, the housing of the detector is provided with a sample solution inlet, a sample solution outlet, a power supply socket, a liquid crystal displayer, an operation keypad and a detection signal output interface, and a detection electromechanical member is arranged inside the housing and comprises a central controller, a detection pool, a fore-lying subtraction module, a polarity conversion module, a noise processing module and an output amplification module. According to the present invention, with the pulse ion multifunctional detector, the ion current of the sample directly ionized in the detection pool can be sensitively and accurately detected, the baseline backgrounds produced by various mobile phases can be subtracted, the dynamic noise and drift of the detector can be automatically eliminated, the extremely-high sensitivity and the extremely-high stability of the detector on the liquid chromatography and the ion chromatography can be finally ensured, and the application range can be effectively extended.

Description

technical field [0001] The invention relates to an innovative analysis and detection instrument, in particular to a pulsed ion multi-function detector which is used for both high-performance liquid chromatography and ion chromatography, and also has the excellent function of one machine with multiple functions in liquid chromatography. Background technique [0002] Liquid chromatography is an instrument for qualitative and quantitative detection and analysis of samples. It is widely used in food, medicine, water quality, beverages, biochemical and health care products to detect and analyze sample components. At present, liquid chromatography mainly includes high performance liquid chromatography, ion chromatography, capillary chromatography, gel chromatography, etc. Among them, high performance liquid chromatography (HPLC) and ion chromatography (IC) are the most widely used. [0003] Liquid chromatography and ion chromatography mainly include high-pressure infusion pumps, h...

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Problems solved by technology

[0004] In the prior art, the detector in the high performance liquid chromatograph has only its own detection function, and can only be used for the detection of liquid chromatography, but cannot be applied to the detection of ion chromatography, such as the commonly used ultraviolet absorption detector for the sample of ion chromatography There is no ultraviolet absorption, so it cannot be applied to ion chromatography. Similarly, the detectors in ion chromatography are also difficult to apply to high-performance liquid chromatography. For example, the conductivity detector commonly used in ion chromatography detection is not only much less sensitive than liquid chromatography. There are many kinds of detectors in phase chromatography, and the large-scale baseline background of the mobile phase cannot be deducted, and cumbersome and high-cost ion exchange columns need to be added, and it is difficult to adapt to the various configuration ratios of multiple mobile phases in liquid chromatography Another example is the ion detector used by DIONEX company in the United States for ion chromatography, which has a complex structure because of indirect ionization, and the cost and sales price are very high; another example is another electrochemical detector in ion chromatography, its Due to the chemical reaction of the electrode, the stability and sensitivity of the detector change with time, and the electrode often needs to be decontaminated and cleaned, which is very inconvenient to use, and these types of detectors are not used in high performance liquid chromatography.

Therefore, the generality of the detectors in the current liquid chromatograph is very poor, and it is impossible to realize one machine with multiple functions; and it is difficult to overcome the technical difficulties of the contradiction between sensitivity and stability.

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