Pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography

A high-performance liquid chromatography and ion chromatography technology, applied in the field of pulsed ion multifunctional detectors, can solve problems such as low sensitivity, difficulty in adapting to changes in configuration ratios, complex structures, etc., to achieve sensitive and accurate detection, eliminate dynamic noise, expand The effect of application range

Inactive Publication Date: 2015-10-21
俞嘉德
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In the prior art, the detector in the high performance liquid chromatograph has only its own detection function, and can only be used for the detection of liquid chromatography, but cannot be applied to the detection of ion chromatography, such as the commonly used ultraviolet absorption detector for the sample of ion chromatography There is no ultraviolet absorption, so it cannot be applied to ion chromatography. Similarly, the detectors in ion chromatography are also difficult to apply to high-performance liquid chromatography. For example, the conductivity detector commonly used in ion chromatography detection is not only much less sensitive than liquid chromatography. There are many kinds of detectors in phase chromatography, and the large-scale baseline background of the mobile phase cannot be deducted, and cumbersome and high-cost ion exchange columns need to be added, and it is difficult to adapt to the vari

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  • Pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography
  • Pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography
  • Pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography

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Example Embodiment

[0063] The following specific examples illustrate the implementation of the present invention:

[0064] It should be noted that the forms, proportions, sizes, etc. shown in the accompanying drawings in this specification are only used to match the content disclosed in the specification for people familiar with this technology to understand and read, and are not intended to limit the implementation of the present invention Limiting conditions. At the same time, terms such as "upper", "lower", "left", "right", etc. quoted in this specification are only for ease of description and are not used to limit the scope of the present invention. , The change or adjustment of its relative relationship shall be regarded as the scope of the implementation of the present invention without substantial change of the technical content.

[0065] Such as figure 1 As shown, the present invention provides a pulse ion multifunctional detector for both high performance liquid chromatography and ion chroma...

Example Embodiment

[0086] Example 1

[0087] Pulse ion multifunctional detector used in liquid chromatograph

[0088] Test sample: Glycerol (standard test sample for refractive index detector)

[0089] Detection environment: chromatographic separation column: C18, ODS; flow rate: 0.6ml / min; mobile phase: 100% methanol

[0090] The chromatogram after detection is as follows Figure 4 Shown.

[0091] Brief description: In addition to this sample, other samples of the refractive index detector can also be tested.

Example Embodiment

[0092] Example 2

[0093] Pulse ion multifunctional detector used in liquid chromatograph

[0094] Test sample: Nongfu Spring Pure Water

[0095] Detection environment: chromatographic separation column: C18, ODS; flow rate: 0.6ml / min; mobile phase: 100% methanol

[0096] The chromatogram after detection is as follows Figure 5 Shown.

[0097] Brief description: It is difficult for other high performance liquid chromatography and ion chromatography detectors to detect water, and this invention can detect it well, and can be used to detect and analyze the purity or pollution of water.

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Abstract

The present invention provides an innovative pulse ion multifunctional detector for high-performance liquid chromatography and ion chromatography, wherein the attached experiment spectrogram shows that the detector further has the excellent function of multi-use-in-one-machine in liquid chromatography. According to the pulse ion multifunctional detector, the housing of the detector is provided with a sample solution inlet, a sample solution outlet, a power supply socket, a liquid crystal displayer, an operation keypad and a detection signal output interface, and a detection electromechanical member is arranged inside the housing and comprises a central controller, a detection pool, a fore-lying subtraction module, a polarity conversion module, a noise processing module and an output amplification module. According to the present invention, with the pulse ion multifunctional detector, the ion current of the sample directly ionized in the detection pool can be sensitively and accurately detected, the baseline backgrounds produced by various mobile phases can be subtracted, the dynamic noise and drift of the detector can be automatically eliminated, the extremely-high sensitivity and the extremely-high stability of the detector on the liquid chromatography and the ion chromatography can be finally ensured, and the application range can be effectively extended.

Description

technical field [0001] The invention relates to an innovative analysis and detection instrument, in particular to a pulsed ion multi-function detector which is used for both high-performance liquid chromatography and ion chromatography, and also has the excellent function of one machine with multiple functions in liquid chromatography. Background technique [0002] Liquid chromatography is an instrument for qualitative and quantitative detection and analysis of samples. It is widely used in food, medicine, water quality, beverages, biochemical and health care products to detect and analyze sample components. At present, liquid chromatography mainly includes high performance liquid chromatography, ion chromatography, capillary chromatography, gel chromatography, etc. Among them, high performance liquid chromatography (HPLC) and ion chromatography (IC) are the most widely used. [0003] Liquid chromatography and ion chromatography mainly include high-pressure infusion pumps, h...

Claims

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Application Information

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IPC IPC(8): G01N30/62
Inventor 俞嘉德
Owner 俞嘉德
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