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Medicine composite of honeysuckle hydrochloric acid extract injection and preparation method thereof

A technology of honeysuckle and extract, which is applied in the field of medicine, can solve problems such as the drop of pH value of the solution, the acceleration of the pH value of the liquid medicine, and the easy rancidity of polysorbate 80, and achieve high dosage, improved safety, and good safety effects

Inactive Publication Date: 2015-11-25
CHENGDU AIBIKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Honeysuckle 100g

[0020] Scutellaria baicalensis 100g

[0021] Licorice 100g

[0022] Solutol HS-15 ? 2.0g

[0023] Preparation method: decoct honeysuckle and scutellaria baicalensis twice with water, 2 hours each time, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; licorice is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, and add ethanol Let the ethanol content be 65%, stand...

Embodiment 2

[0025] Honeysuckle 100g

[0026] Scutellaria baicalensis 100g

[0027] Licorice 100g

[0028] Solutol HS-15 ? 1.0g

[0029] Tween 801.0g

[0030] Preparation method: decoct honeysuckle and scutellaria baicalensis twice with water, 2 hours each time, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; licorice is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, and add ethanol Let the ethano...

Embodiment 3

[0032] Honeysuckle 100g

[0033] Scutellaria baicalensis 100g

[0034] Licorice 100g

[0035] Solutol HS-15 ? 2.0g

[0036] Preparation method: decoct honeysuckle and scutellaria baicalensis twice with water, 2 hours each time, combine the decoctions, filter, concentrate the filtrate under reduced pressure to a relative density of 1.27-1.30 (80°C), let it cool, add ethanol to make the ethanol content be 65%, stand overnight, filter, the filtrate is decompressed to recover ethanol and concentrated to a relative density of 1.30 (80°C), add 3 times the amount of water, stir well, refrigerate for 48 hours, filter, and the filtrate is concentrated to a relative density under reduced pressure About 1.15 (80°C), the medicinal liquid is for later use; licorice is decocted twice with water, 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25-1.30 (80°C), let cool, and add ethanol Let the ethanol content be 65%, stand...

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Abstract

The invention discloses a medicine composite of honeysuckle hydrochloric acid extract injection and a preparation method thereof. The medicine composite for injection is mainly prepared from honeysuckle extract, scutellaria extract, licorice extract and polyethylene glycol dodecahydroxyl stearic acid ester. A hydrotropic agent higher in safety and more obvious in hydrotropic effect is adopted for replacing a hydrotropic agent-polysorbate 80, causing potential safety hazards and influencing product quality, in compound honeysuckle injection, and the polyethylene glycol dodecahydroxyl stearic acid ester is higher in safety and smaller in dosage compared with polysorbate 80, so that the probability and risk of adverse drug reactions are reduced, and clinical drug use safety is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition of honeysuckle hydrochloric acid extract injection and a preparation method thereof. Background technique [0002] The standard of compound honeysuckle injection is recorded in the drug standard issued by the Ministry of Health (Chinese medicine prescription preparation). The raw materials are honeysuckle, scutellaria baicalensis and licorice. sleep aid. [0003] Compound honeysuckle injection has been widely used clinically in my country for many years, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditional Chinese medicine injections have been increasing, which has affected the development of traditional Chinese medicine injections with Chinese medical characteristics. Domestic experts and scholars have conducted a...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K47/34A61K9/08A61K9/14A61K9/19A61P29/00A61P25/20
Inventor 何金蓉
Owner CHENGDU AIBIKE BIOTECH
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