31 results about "Polysorbate ester" patented technology

The invention relates to a method for synthesizing high-purity polysorbate-80. The polysorbate-80 (I) is a partial esterified product of a sorbitan ethyoxyl compound and oleic acid. The method comprises the following steps of: (1) partially dehydrating sorbitol as a raw material under the action of an acid catalyst in a state of vacuum to obtain sorbitan (II); (2) carrying out addition polymerization on the sorbitan (II) and oxirane under the action of a base catalyst to obtain sorbitan polyethenoxy ether (III), wherein the addition number of the oxirane is 20; (3) reacting the sorbitan polyethenoxy ether (III) with the high-purity oleic acid under the action of an esterifying catalyst and refining to obtain the high-purity polysorbate-80. The invention leads the emulsifying and solubilizing performance of products to be more perfect and the quality of the products to easily meet the requirement of an injection class and has easily controlled quality and good stability; and the high-purity polysorbate-80 has lower blood dissolving rate in same concentration, and predictable and safer clinical use by being used as an auxiliary material for injection.

The invention discloses a pharmaceutical composition for improving the safety of Shenmai injection and a method for preparing the same. The pharmaceutical composition is a pharmaceutical composition for injection and is mainly prepared from red ginseng extract, dwarf lilyturf root extract and polyethylene glycol 12-hydroxy stearic acid ester. The pharmaceutical composition adopts a latent solvent with better safety and more obvious hydrotropy to replace the latent solvent polysorbate-80 which has potential safety hazard and influences the product quality, thus the reduction of the pH value of the Shenmai injection in the processes of storing and high temperature sterilization is obviously delayed, and the stability of the pharmaceutical composition is increased; besides, the safety of the polyethylene glycol 12-hydroxy stearic acid ester is higher than that of the polysorbate-80 and the dosage thereof is lower, thus the probability and the risk of untoward reactions of the pharmaceutical composition is reduced, and the safety for clinical application is improved.

The invention belongs to the technical field of chemical preparations and particularly relates to a formaldehyde scavenger and a preparation method thereof. The formaldehyde scavenger comprises the following raw materials in parts by weight: 10-20 parts of amino acid, 10-20 parts of starch, 5-10 parts of casein, 5-10 parts of polysorbate, 10-15 parts of isoamyl alcohol, 30-50 parts of plant flower extracts, 5-10 parts of active carbon carboxymethylcellulose, 6-8 parts of a penetrant, 5-10 parts of pillared rectorite, 10-20 parts of chitosan and 80-120 parts of deionized water. The formaldehyde scavenger provided by the invention is high in absorption efficiency and capable of eliminating free formaldehyde in air, reducing the release amount of formaldehyde in a decorated product and simultaneously improving the stability of the formaldehyde in the decorated product so as to solve the problem of formaldehyde pollution caused after indoor decoration and the health of people is beneficial.

The invention discloses an addition agent having a synergistic effect on cement.The addition agent is prepared from, by weight, 5.4-5.8 parts of nitrilotriacetic acid, 1.8-2.4 parts of ethylene diamine tetra (methylene phosphonic acid) sodium, 2.4-2.7 parts of triisopropanolamine, 3.7-4.3 parts of acrylamide, 3.2-3.5 parts of alpha-sodium-olefinsulfonate, 3.3-3.6 parts of useless lubricating oil, 3.9-4.4 parts of lauryl sodium sulfate, 4.9-5.7 parts of urea, 2.2-2.5 parts of calcium lignosulfonate, 0.6-0.8 parts of molasses, 2.6-3.0 parts of sodium thiosulfate, 2.1-2.5 parts of a silicone lubricating agent, 1.5-1.9 parts of a fluorine-containing lubricating agent, 2.1-2.5 parts of polysorbate-80 and 2.3-2.7 parts of sorbitol.The construction efficiency can be improved effectively, price is low, the enhancing effect is remarkable, fallen dust is reduced, resources are saved, the raw materials are wide in source, and the manufacturing technology is simple.

The invention belongs to a technical field of medicine, and particularly relates to a posaconazole oral suspension and a preparation method thereof. 100 ml of the posaconazole oral suspension comprises the following ingredients by weight: 4 parts of posaconazole, 1 part of polysorbate-80, 0.3 part of dimethicone, 0.2 part of sodium benzoate, appropriate parts of sodium citrate, appropriate parts of citric acid, 10 parts of glycerol, 0.3 part of xanthan gum, 35 parts of malt syrup, 0.4 part of titanium dioxide, 0.3 part of essence, and the balance of purified water.

The invention discloses a methanol fuel additive for vehicles and a manufacturing method of the methanol fuel additive. The methanol fuel additive for vehicles is formed by mixing the following components in parts by weight: 9900-10200 parts of ethanol, 198-202 parts of glycol-butyl ether, 198-202 parts of ammonium acetate, 495-505 parts of linoleic acid, 247.5-252.5 parts of glycol, 495-505 parts of polysorbate-80, 2970-3030 parts of seaweed powder and 2970-3030 parts of ping tree powder. The methanol fuel additive for vehicles can effectively improve the performances of methanol fuel for vehicles and the methanol fuel for vehicles added with the additive can prevent an oil pump from being damaged, reduce abrasion of a cylinder and other moving parts, reduce sense of frustration and improve comfort; furthermore, the power can be improved, the oil consumption can be reduced and the acceleration is rapid.

The invention discloses an efficient corrosion-resistant antifreezing fluid, which is characterized by comprising the following components by weight: 10-15 parts of glycerol, 2-4 parts of phthalic anhydride, 10-15 parts of polysorbate, 0.1-0.5 part of potassium nitrate, 0.01-0.05 part of a silicate stabilizer, 1-2 parts of a non-ionic surface active agent, 5-8 parts of epoxy resin, 1-4 parts of borax and the balance of ultra pure water. A high-molecular polymer salt and metal ions can form a high-molecular polymerization membrane for covering the metal surface; and rare-earth salts generate synergism with the corrosion inhibitors to keep the protection film on the metal surface intact, thereby inhibiting metal corrosion.

The invention relates to a method for synthesizing high-purity polysorbate-80. The polysorbate-80 (I) is a partial esterified product of a sorbitan ethyoxyl compound and oleic acid. The method comprises the following steps of: (1) partially dehydrating sorbitol as a raw material under the action of an acid catalyst in a state of vacuum to obtain sorbitan (II); (2) carrying out addition polymerization on the sorbitan (II) and oxirane under the action of a base catalyst to obtain sorbitan polyethenoxy ether (III), wherein the addition number of the oxirane is 20; (3) reacting the sorbitan polyethenoxy ether (III) with the high-purity oleic acid under the action of an esterifying catalyst and refining to obtain the high-purity polysorbate-80. The invention leads the emulsifying and solubilizing performance of products to be more perfect and the quality of the products to easily meet the requirement of an injection class and has easily controlled quality and good stability; and the high-purity polysorbate-80 has lower blood dissolving rate in same concentration, and predictable and safer clinical use by being used as an auxiliary material for injection.

The invention belongs to the technical field of biology, and particularly relates to a novel PEG-modified recombinant human granulocyte colony-stimulating factor preparation. The PEG-modified recombinant human granulocyte colony-stimulating factor preparation at least comprises pegylated recombinant human granulocyte colony-stimulating factors, auxiliary materials and water for injection, whereinthe concentration of the PEG-modified recombinant human granulocyte colony-stimulating factors is 5-15 mg / mL, and the pH value of the PEG-modified recombinant human granulocyte colony-stimulating factor preparation is 4-4.4. According to the novel pegylated recombinant human granulocyte colony-stimulating factor preparation provided by the invention, the use of polysorbate as a stabilizer is avoided, and the human body is unlikely to suffer from side effects of blood pressure reduction, heart rate acceleration, hemolysis and the like. Arginine is used for replacing polysorbate, so that a stabilizing effect on a protein structure is achieved, the formation of protein aggregates is remarkably reduced, and the stability effect on the pegylated recombinant human granulocyte colony-stimulatingfactors is remarkably improved.

The invention discloses an environment-friendly skidproof rubber formula. The environment-friendly skidproof rubber comprises the following ingredients in parts by weight: butyl rubber, n-propyl methacrylate, parachlorometaxylenol, nitrile rubber buna, paraffin oil, magnesium oxide, linear aliphatic epoxy resin, an activator, chitosan, stearic acid, a plasticizer, citric acid ester, metronidazole, polysorbate, peppermint camphor, white carbon black, a vulcanizing agent and an accelerating agent. The rubber is low in cost, environment-friendly and skidproof, and has a wide application range.

The invention discloses a medicine composite of honeysuckle hydrochloric acid extract injection and a preparation method thereof. The medicine composite for injection is mainly prepared from honeysuckle extract, scutellaria extract, licorice extract and polyethylene glycol dodecahydroxyl stearic acid ester. A hydrotropic agent higher in safety and more obvious in hydrotropic effect is adopted for replacing a hydrotropic agent-polysorbate 80, causing potential safety hazards and influencing product quality, in compound honeysuckle injection, and the polyethylene glycol dodecahydroxyl stearic acid ester is higher in safety and smaller in dosage compared with polysorbate 80, so that the probability and risk of adverse drug reactions are reduced, and clinical drug use safety is improved.

The invention discloses improved antifreeze fluid for automobiles. The improved antifreeze fluid is made of, by weight, 3-9 parts of polysorbate, 2-7 parts of petroleum resin, 1-5 parts of sodium hydroxide, 6-11 parts of sebacic acid, 4-8 parts of boron-phenolic resin, 3-6 parts of gamma- aminopropyl triethoxysilane, 5-9 parts of glycidyl ester, 2-6 parts of hydrogen peroxide, 5-8 parts of calcium stearate, 1-4 parts of lanolin, 2-5 parts of toluoyl triazole, 2-4 parts of aqueous wetting agent, 2-6 parts of silanes, 6-8.6 parts of maleic anhydride and 3-6.5 parts of white oil. The improved antifreeze fluid has the advantages of environment friendliness, excellent antifreeze performance, avoidance of engine corrosion and improvement of utilization efficiency of engines.

A synthesis method of polysorbate 80 with low polysorbitol content comprises the steps: (1) preparation of sorbitan: dehydrating sorbitol in a vacuum state under the action of a catalyst to prepare sorbitan; (2) separation of polysorbitol in sorbitan: mixing sorbitan, low-carbon alcohol and an adsorbent, then carrying out heating dissolving, carrying out cooling crystallization and drying in vacuum to obtain refined sorbitan; (3) preparation of sorbitan oleate: mixing the refined sorbitan with oleic acid, and carrying out an esterification reaction under the action of a catalyst, to prepare sorbitan oleate; and (4) synthesis of polysorbate 80: carrying out an addition polymerization reaction of sorbitan oleate and about 20 moles of ethylene oxide under the action of a catalyst to prepare polysorbate 80. Polysorbitol in the polysorbate 80 is removed, the hydroxyl value of refined sorbitan is controlled, the relative stability of the components is ensured, the content of the polysorbitol(<0.1%) is reduced and the biological safety of the polysorbate 80 product is improved.

The invention discloses a method for preparing an allicin sustained-release microcapsule preparation by a carrier adsorption and homogeneous precipitation coupling method. The allicin sustained-release microcapsule preparation is characterized by comprising the following components in percentage by mass: 0.1-20% of allicin, 2-50% of a solid adsorbent, 0.1-10% of an emulsifier, and 20-70% of calcium alginate. The emulsifier is selected from at least one of polysorbate-80, sucrose ester and polyglycerol fatty ester; and the solid adsorbent is selected from at least one of silica gel G, white carbon black and attapulgite. A calcium alginate coating on the outer layer of an allicin sustained-release microcapsule preparation particle provided by the invention is not liable to dissolve in water,pressure-resistant, wear-resistant and not liable to break, the allicin can be slowly released only after the coating is damaged in gastric acid, the calcium alginate coating powerfully prevents volatilization and oxidation loss of the allicin, and the bioavailability of the allicin is greatly improved.

The invention discloses a method for making a base asphalt warm-mix rejuvenator. The method comprises: 1) adding sodium α-alkenyl sulfonate into water and stirring until the sodium α-alkenyl sulfonate is completely dissolved to obtain a solution; 2) Add 80-type polysorbate and triethanolamine to solution A, and use a high-speed shearing machine at a speed of 2000r / min to shear until mixed evenly to obtain solution B; 3) Add RA‑2 regeneration agent to solution B, And use a high-speed shearing machine to shear at a speed of 3000r / min until the mixture is evenly mixed, and the obtained product is the base asphalt warm mix rejuvenator. The beneficial technical effects of the present invention are: a method for making matrix asphalt warm-mix rejuvenator is proposed, and the prepared matrix asphalt warm-mix rejuvenator can recover and regenerate the performance of aged matrix asphalt under warm-mix conditions, which can effectively reduce production Energy consumption and pollution in the process.

The invention discloses environment-friendly anti-freezing fluid for an automobile. The anti-freezing fluid is prepared from the following ingredients in parts by weight: 3-5 parts of benzotriazole, 60-80 parts of diethylene glycol-methyl ether, 2-3 parts of calcium formate, 0.1-0.5 part of fulvic acid, 0.3-0.5 part of isopropyl nitrate, 20-30 parts of sodium nitrate, 0.1-0.5 part of sodium phosphate, 0.3-0.5 part of polysorbate and 20-30 parts of distilled water. The anti-freezing fluid is reasonable in formula, good in use effect and low in production cost.

The invention discloses ink, comprising 20-35 parts of ink base, 5-10 parts of adsorbent, 0.01-0.05 part of polysorbate-80, 20-30 parts of reducer, 5-10 parts of titanate coupling agent, 5-10 parts of dispersant, and 1-5 parts of metal paste. The metal paste is silver or gold paste, the ink base is at least one of green ink, yellow ink, golden red ink or deep blue ink. Polysorbate-80 forms a protective layer on the surface of metal powder and adsorbent to be attracted with adsorbent with the polar group. A great deal of adsorbent contacts and is combined with the surface of the metal powder. The titanate coupling agent is of long-chain structure, epoxy resin is of three-dimensional mesh structure, and the polysorbate-80, the titanate coupling agent and the epoxy resin are made up of a special brightness enhancement film after ultrasonic treatment. Therefore, ink brightness after added with metal powder is increase by more than 20%. The more stable structure is formed under the combined action of the epoxy and the titanate coupling agent, so that ink can be kept in bright color for a long time.

The invention relates to a noncorrosive automobile brake fluid which is prepared from the following raw materials in parts by weight: 6-8 parts of hindered phenol antioxidant, 11-14 parts of diethylene glycol-methyl ether, 3-10 parts of sebacic acid, 4-9 parts of sodium benzoate, 3-5 parts of polysorbate, 8-10 parts of glycerol, 7-11 parts of lauryl sodium sulfate, 5-8 parts of 2,6-di-tert-butyl-para-cresol, 6-8 parts of nonylphenol polyethenoxy ether, 1-4 parts of tea polyphenol, 2-6 parts of lubricant, 9-14 parts of castor oil, 5-10 parts of butanol and 6-11 parts of dimethyl silicone oil. The automobile brake fluid has the advantages of favorable low-temperature fluidity, high boiling point and no corrosiveness to the braking system.

The invention discloses environment-friendly anti-freezing fluid for an automobile. The anti-freezing fluid is prepared from the following ingredients in parts by weight: 3-5 parts of benzotriazole, 60-80 parts of diethylene glycol-methyl ether, 2-3 parts of glacial acetic acid, 0.1-0.5 part of brassin, 0.3-0.5 part of vinyl acetate, 20-30 parts of sodium nitrate, 0.1-0.5 part of sodium phosphate, 0.3-0.5 part of polysorbate and 20-30 parts of distilled water. The anti-freezing fluid is reasonable in formula, good in use effect and low in production cost.

The invention discloses a universal environment-friendly anti-freezing solution for vehicles, which is characterized by comprising the following components in parts by weight: 10-15 parts of ethylene glycol at dacron grade, 6-8 parts of sodium stannate, 2-3 parts of alizarin red, 5-10 parts of potassium hydroxide, 0.1-0.5 part of dodecyl dimethyl benzyl ammonium chloride, 3-5 parts of borax, 5-10 parts of a non-ionic emulsifier, 3-5 parts of polysorbate, and 10-15 parts of water. The universal environment-friendly anti-freezing solution is high in flash point, excellent in safety, small in environmental load, excellent in stability performance, anti-freezing, anticorrosive, and difficult to scale, thereby being the novel automotive anti-freezing solution suitable for being widely used and particularly applicable to components such as engines of vehicles, tractors and other motor vehicles or motorized equipment.

The invention discloses an environment-friendly anti-freezing fluid for an automobile. The anti-freezing fluid is prepared from the following components in parts by weight: 3-5 parts of benzotriazole, 60-80 parts of diethylene glycol monomethyl ether, 4-5 parts of methyl silicon oil, 2-4 parts of triethanolamine, 0.4-0.6 part of benzotriazole, 20-30 parts of sodium nitrate, 0.1-0.5 part of sodium phosphate, 0.3-0.5 part of polysorbate and 20-30 parts of distilled water. The anti-freezing fluid is reasonable in formula, good in using effect and low in production cost.

The invention discloses ink, comprising 20-35 parts of ink base, 5-10 parts of adsorbent, 0.01-0.05 part of polysorbate-80, 20-30 parts of reducer, 5-10 parts of titanate coupling agent, 5-10 parts of dispersant, and 1-5 parts of metal paste. The metal paste is silver or gold paste, the ink base is at least one of green ink, yellow ink, golden red ink or deep blue ink. Polysorbate-80 forms a protective layer on the surface of metal powder and adsorbent to be attracted with adsorbent with the polar group. A great deal of adsorbent contacts and is combined with the surface of the metal powder. The titanate coupling agent is of long-chain structure, epoxy resin is of three-dimensional mesh structure, and the polysorbate-80, the titanate coupling agent and the epoxy resin are made up of a special brightness enhancement film after ultrasonic treatment. Therefore, ink brightness after added with metal powder is increase by more than 20%. The more stable structure is formed under the combined action of the epoxy and the titanate coupling agent, so that ink can be kept in bright color for a long time.

The invention discloses an environment-friendly anti-freezing fluid for an automobile. The anti-freezing fluid is prepared from the following components in parts by weight: 3-5 parts of benzotriazole, 60-80 parts of diethylene glycol monomethyl ether, 4-5 parts of isocaprylic acid, 2-4 parts of p-nitrophenol, 0.4-0.6 part of polysiloxane, 0.4-0.6 part of benzotriazole, 20-30 parts of sodium nitrate, 0.1-0.5 part of sodium phosphate, 0.3-0.5 part of polysorbate and 20-30 parts of distilled water. The anti-freezing fluid is reasonable in formula, good in using effect and low in production cost.

The invention provides a cabazitaxel injection. The cabazitaxel injection comprises the following components in parts by mass: 10 parts of cabazitaxel, 200-270 parts of polysorbate 80, 400-500 parts of polyethylene glycol and 1,000 parts of ethanol. The product is good in stability, easy to filter and fill, and convenient to use in clinic.

The invention discloses activated graphene dispersion liquid, a method for preparing the same and application of the activated graphene dispersion liquid to conductive thin films. The activated graphene dispersion liquid comprises, by weight, 30-40 parts of graphene, 0.1-0.2 part of polysorbate, 6-9 parts of potassium permanganate, 2-4 parts of chlorosulfonic acid, 0.7-1 part of barium naphthenateand 100-120 parts of dimethylformamide. The activated graphene dispersion liquid, the method and the application have the advantages that phosphorus trichloride is used as a modifier, is hydrolyzed and then is doped in aniline monomers, and accordingly polyaniline is excellent in conductivity; the polyaniline and bisphenol A are blended and esterified, obtained bisphenol A ester is excellent in heat-resistant stability, and accordingly the heat-resistant strength of the thin films which are finished products can be improved; the thin films are good in conductive stability and heat-resistant stability, high in mechanical strength and excellent in comprehensive performance.

The invention discloses a formula of anti-coking polyvinylidene fluoride. The formula comprises modified polyvinylidene fluoride, an anti-coking agent, a cross-linking agent and a solubilizer, wherein the anti-coking agent is o-phthalic anhydride, the cross-linking agent is di-t-butyl peroxide, and the solubilizer is polysorbate and fatty acid ethoxylate; and the modified polyvinylidene fluoride accounts for 40%-50%, the o-phthalic anhydride accounts for 13%-17%, the di-t-butyl peroxide accounts for 11%-14%, the polysorbate accounts for 17%-18%, and the fatty acid ethoxylate accounts for 8%-11%. The prepared anti-coking polyvinylidene fluoride has the advantages of excellent dielectric property, impact resistance, high chemical stability and high using temperature.

The invention discloses an automobile environment-friendly antifreezing solution. The automobile environment-friendly antifreezing solution is composed of, by weight, 3-5 parts of benzotriazole, 1-3 parts of lanolin, 4-5 parts of sodium chloride, 2-4 parts of polyoxyethylene, 0.1-0.5 part of brassin, 0.3-0.5 part of vinyl acetate, 20-30 parts of sodium nitrate, 0.1-0.5 part of sodium phosphate, 0.3-0.5 part of polysorbate and 20-30 parts of distilled water. The automobile environment-friendly antifreezing solution is reasonable in formula, good in using effect and low in production cost.

The invention discloses a formula of anti-coking polyvinylidene fluoride. The formula comprises modified polyvinylidene fluoride, an anti-coking agent, a cross-linking agent and a solubilizer, wherein the anti-coking agent is o-phthalic anhydride, the cross-linking agent is di-t-butyl peroxide, and the solubilizer is polysorbate and fatty acid ethoxylate; and the modified polyvinylidene fluoride accounts for 40%-50%, the o-phthalic anhydride accounts for 13%-17%, the di-t-butyl peroxide accounts for 11%-14%, the polysorbate accounts for 17%-18%, and the fatty acid ethoxylate accounts for 8%-11%. The prepared anti-coking polyvinylidene fluoride has the advantages of excellent dielectric property, impact resistance, high chemical stability and high using temperature.