9 results about "Polysorbate ester" patented technology

The invention relates to the field of daily chemicals, provides a hair care composition with low water content or even no water content, and solves the technical problem that a system with low water content and high polyol content is too high in consistency by adding a small amount of polysorbate. The high-concentration polyhydric alcohol can significantly improve the moisture retention performance of hair, can promote permeation of protein and polypeptide raw materials on hair, effectively repair damaged hair, can reduce the use amount of quaternization components in a hair conditioner system to a certain extent, and has reduced irritation compared with traditional hair conditioners. The hair can be smoother and not frizzy after being used, the combing property of the hair is improved, the heat feeling experience can be brought, and a new formula development thought is provided for heating and hair care products.

The invention belongs to the technical field of biological enzyme preservation, and particularly relates to a bromelain freeze-drying protective agent and a preparation method thereof. The trehalose and pulullan compound freeze-dried powder injection is prepared from the following components in parts by weight: 30 to 50 parts of trehalose, 8 to 10 parts of pulullan, 3 to 10 parts of maltodextrin, 12 to 22 parts of mannitol, 1 to 4 parts of sorbitol, 4 to 12 parts of glycine, 0.05 to 0.2 part of polysorbate-20, 1.5 to 4.5 parts of a buffering agent, 0.2 to 0.8 part of N-acetylcysteine, 0.05 to 0.3 part of oxidized glutathione, 0.8 to 2.5 parts of PEG (Polyethylene Glycol) and 0.05 to 0.3 part of an antioxidant. According to the invention, trehalose-pullulan is taken as a main skeleton, so that the growth of ice crystals is inhibited, and the water activity is reduced; mannitol constructs a crystal phase support network, and polysorbate-20 stabilizes an interface; sulfydryl is temporarily sealed through oxidized glutathione, and controllable reduction during redissolution is realized through microencapsulated N-acetylcysteine; and a sodium phosphate buffer system keeps the pH stable.

The invention discloses a method for detecting polysorbate 80 based on an MALDI-MS and UHPLC-Q-TOF / MS. The method comprises the following steps: taking a polysorbate 80 sample, preparing a polysorbate 80 solution by using acetonitrile, respectively carrying out MALDI-MS detection and UHPLC-Q-TOF / MS detection on the polysorbate 80 solution, and determining the content of the polysorbate 80 in the polysorbate 80 sample according to the MALDI-MS and UHPLC-Q-TOF / MS detection results. The method comprises the following steps: acquiring PS80 principal component distribution according to an MALDI-MS (Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry) map: a polyoxyethylene chain delta m / z 44.0 + / -0.2 and an esterified derivative sodium adduct ion gradient peak cluster, and carrying out qualitative analysis on components of the polysorbate 80 in combination with a characteristic interval of m / z 44.0 + / -0.2 in the MALDI map; according to the retention time in the UHPLC-Q-TOF / MS detection result, identifying the monoester, diester and trace unesterified sorbitan in the polysorbate 80. According to the invention, molecular weight distribution analysis and component separation and identification of PS80 are realized.

The invention discloses a method for determining activity of host cell proteolytic enzyme of hydrolyzed polysorbate, and belongs to the technical field of biological detection. The method comprises the following steps: adding a solid-phase reaction substrate (containing a polysorbate analogue) and a to-be-detected sample into a buffer solution to react, removing the solid-phase reaction substrate by utilizing a magnetic adsorption method after the reaction is finished, and carrying out fluorescent quantitative PCR amplification reaction on the residual reaction solution to determine the content of free DNA in the reaction solution. Host cell proteolytic enzyme activity to hydrolyze polysorbate is determined by free DNA content. The method effectively solves the problems of insufficient sensitivity, complex operation and unstable result in the traditional detection method, obviously improves the detection precision and the experimental operation efficiency, enhances the quality monitoring in the drug research and development stage and the safety guarantee of the final product, improves the quality control level of the protein biological drugs, and has a wide application prospect. The effectiveness and the safety of the protein biological medicine in clinical medication are ensured.

The invention discloses a ketotifen fumarate nasal spray. The ketotifen fumarate nasal spray comprises ketotifen fumarate, water, a stabilizer ergothioneine and isopropanol, and an absorption enhancer polysorbate 20. According to the ketotifen fumarate nasal spray, ergothioneine and isopropanol are used as stability, so that the problem that the drug stability is reduced after an absorption enhancer is added can be solved, the ketotifen fumarate nasal spray enters the brain after passing through the nasal cavity and can quickly take effect, and the sleep promoting effect is remarkably improved.

The invention discloses a phloretin solution for poultry. The phloretin solution is prepared from the following components in parts by mass: 1 part of phloretin, 20 to 35 parts of ethanol serving as a solvent, 2.5 to 7.5 parts of polysorbate 80 serving as a cosolvent, 0.008 to 0.2 part of butylated hydroxytoluene serving as an antioxidant, 0.01 to 0.05 part of phosphoric acid serving as a synergist serving as an antioxidant and 5 to 20 parts of purified water. The preparation method comprises the following steps: dissolving phloretin and butylated hydroxytoluene in ethanol, adding polysorbate 80 and phosphoric acid, adding water to a constant volume, and filtering. The problem that phloretin is easy to separate out when being mixed with water to be administered is solved, the solution stability is high, accurate administration can be achieved, the composition is suitable for preventing necrotic enteritis caused by clostridium welchii in poultry intensive breeding, and the policy requirements of resisting limitation and resisting replacement are met.

The invention discloses a superoxide dismutase eye care solution and a preparation method thereof, and relates to the technical field of eye care. Comprising the following raw materials in parts by weight: purified water, a sodium citrate / citric acid buffer system, an isoosmotic adjusting agent, superoxide dismutase (SOD), ethylene diamine tetraacetic acid disodium EDTA-2Na, methionine, reduced glutathione, polysorbate-80, sodium hyaluronate, polyquaternium-1, a sodium hydroxide solution, a hydrochloric acid solution and zinc sulfate heptahydrate. The care solution is prepared based on the raw materials. In a purified water system, in combination with a sodium citrate / citric acid buffer system, an isoosmotic adjusting agent and a chelating-compensation sequence controlled metal ion environment, the high activity of superoxide dismutase in a solution state is maintained, meanwhile, methionine, reduced glutathione and polysorbate-80 are matched to form a synergistic stable system, and the superoxide dismutase can be used for preparing the superoxide dismutase. The oxidation resistance and the storage stability of the care solution are obviously improved.

The invention belongs to the field of macromolecules, and relates to a fat aromatic copolyester foaming composition, fat aromatic copolyester foaming beads, a preparation method of the fat aromatic copolyester foaming beads and a foaming bead forming body. The composition comprises fat aromatic copolyester, a shrinkage inhibitor, a stiffening agent, a compatilizer and an auxiliary agent, based on 100 parts by weight of the fat aromatic copolyester, the content of the shrinkage inhibitor is 0.2-2 parts by weight, the content of the stiffening agent is 0.2-5 parts by weight, the content of the compatilizer is 0.1-2 parts by weight, and the content of the assistant is 0.01-2 parts by weight; the shrinkage inhibitor is selected from at least one of polysorbate, sucrose ester, sorbitan fatty acid ester, palmitic acid diglyceride and isosorbide dinitrate. The shrinkage inhibitor, the stiffening agent and the compatilizer are used and play a synergistic effect, so that the shrinkage rate of the fat aromatic copolyester-based foamed bead is obviously reduced, and the application fields of a molded body in electronic and electric appliance packaging, precision mechanical product packaging and the like are expanded.

The invention relates to the technical field of shampoo, in particular to anti-hair-loss and hair-care shampoo and a preparation method thereof. Comprising sodium laureth sulfate, cocamidopropyl betaine, polysorbate 80, adenosine, sulfydryl polyethylene glycol modified beta-cyclodextrin, selenized maleimide modified polyvinyl alcohol, propyl gallate, sodium chloride, phenoxyethanol, citric acid and essence. According to the anti-hair loss shampoo disclosed by the invention, the problem that adenosine is continuously damaged by hydroperoxide generated by automatic oxidation of polysorbate 80 in an existing anti-hair loss shampoo formula is effectively solved through three components, namely the sulfydryl polyethylene glycol modified beta-cyclodextrin, the selenized maleimide modified polyvinyl alcohol and the propyl gallate.