Method for preparing allicin microcapsules through carrier adsorption and precipitation coupling
A technology of allicin and solid adsorbent, applied in the direction of microcapsules, capsule delivery, drug combination, etc., can solve the problems of easy decomposition, insoluble in water, unstable chemical properties, etc., and achieve unbreakable, fluidity and dispersibility Good, avoid volatilization and oxidation loss effect
Examples
Embodiment 1
[0033] Prepare the allicin sustained-release microcapsule preparation according to the following steps:
[0034] S1. Weigh 100g of allicin raw material and 25g of polysorbate-80 in sequence according to the proportion, add it into 75g of purified water, and shear, stir and emulsify at room temperature at a speed of 1000r / min in a closed reactor for 30min to obtain mixture A;
[0035] S2. Stir 100g of silica gel G at a speed of 60r / min, slowly drop the mixture A into the stirring silica gel G within 30min, continue stirring for 30min after dripping, until there is no obvious liquid on the surface of the solid adsorbent, the mixture B is obtained;
[0036] S3. Weigh 10 g of sodium alginate and add it into 100 g of water, stir at room temperature for 30 min at a speed of 500 r / min to obtain a transparent colloid, namely mixture C, and the viscosity of mixture C is 8901 mPa·s.
[0037] S4. Weigh 20 g of calcium chloride and add it into 30 g of water, and stir at room temperature u...
Embodiment 2
[0042] Prepare the allicin sustained-release microcapsule preparation according to the following steps:
[0043] S1. Weigh 100g of allicin raw material and 50g of sucrose ester in sequence according to the proportion, add them into 100g of purified water, and shear, stir and emulsify at room temperature at a speed of 1500r / min in a closed reaction kettle for 45min to obtain mixture A;
[0044] S2. Stir 150g of white carbon black at a speed of 60r / min, slowly drop the mixture A into the stirring silica gel G within 30min, continue to stir for 30min after the dripping, until there is no obvious liquid on the surface of the solid adsorbent, the mixture B is obtained ;
[0045] S3. Weigh 15 g of sodium alginate and add it into 200 g of water, stir at room temperature for 30 min at a speed of 500 r / min to obtain a transparent colloid, namely mixture C, and the viscosity of mixture C is 11527 mPa·s.
[0046] S4. Weigh 30 g of calcium chloride and add it into 60 g of water, stir at ...
Embodiment 3
[0051] Prepare the allicin sustained-release microcapsule preparation according to the following steps:
[0052] S1. Weigh 100 g of allicin raw material and 30 g of polyglycerol fatty ester in sequence according to the proportion, add it into 70 g of purified water, and shear, stir and emulsify at room temperature at a speed of 2000 r / min in a closed reactor for 20 minutes to obtain mixture A;
[0053] S2. Stir 200g of attapulgite at a speed of 60r / min, slowly drop the mixture A into the stirring silica gel G within 30min, continue stirring for 30min after the dripping is completed, until there is no obvious liquid on the surface of the solid adsorbent, the mixture B is obtained ;
[0054] S3. Weigh 20 g of sodium alginate and add it into 250 g of water, stir at room temperature at a speed of 500 r / min for 45 min to obtain a transparent colloid, namely mixture C, and the viscosity of mixture C is 12046 mPa·s.
[0055] S4. Weigh 40 g of calcium chloride and add it to 80 g of w...
PUM
Login to View More Abstract
Description
Claims
Application Information
- IPC
- A61K9/50; A61K9/52; A61K47/36; A61K31/255; A61P31/04; A61P29/00; A61P35/00; A61P39/06; A61P37/04; A61P9/00
- CPC
- A61K9/5036; A61K31/255; A61P31/04; A61P29/00; A61P35/00; A61P39/06; A61P37/04; A61P9/00
- Inventors
- 乔宽; 陶正国