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Method for preparing allicin microcapsules through carrier adsorption and precipitation coupling

A technology of allicin and solid adsorbent, applied in the direction of microcapsules, capsule delivery, drug combination, etc., can solve the problems of easy decomposition, insoluble in water, unstable chemical properties, etc., and achieve unbreakable, fluidity and dispersibility Good, avoid volatilization and oxidation loss effect

Inactive Publication Date: 2020-11-03
GUANGZHOU LEADER BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Allicin is easily soluble in organic solvents, but hardly soluble in water (solubility 2.5%). The fat-soluble and irritating properties of allicin lead to the use of organic solvents and special solubilizers in the preparation process of allicin, so that allicin The preparation produces corresponding toxic effects, and serious consequences occur during use, and its chemical properties are extremely unstable, and it is easy to decompose when encountering alkali or heat

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Prepare the allicin sustained-release microcapsule preparation according to the following steps:

[0034] S1. Weigh 100g of allicin raw material and 25g of polysorbate-80 in sequence according to the proportion, add it into 75g of purified water, and shear, stir and emulsify at room temperature at a speed of 1000r / min in a closed reactor for 30min to obtain mixture A;

[0035] S2. Stir 100g of silica gel G at a speed of 60r / min, slowly drop the mixture A into the stirring silica gel G within 30min, continue stirring for 30min after dripping, until there is no obvious liquid on the surface of the solid adsorbent, the mixture B is obtained;

[0036] S3. Weigh 10 g of sodium alginate and add it into 100 g of water, stir at room temperature for 30 min at a speed of 500 r / min to obtain a transparent colloid, namely mixture C, and the viscosity of mixture C is 8901 mPa·s.

[0037] S4. Weigh 20 g of calcium chloride and add it into 30 g of water, and stir at room temperature u...

Embodiment 2

[0042] Prepare the allicin sustained-release microcapsule preparation according to the following steps:

[0043] S1. Weigh 100g of allicin raw material and 50g of sucrose ester in sequence according to the proportion, add them into 100g of purified water, and shear, stir and emulsify at room temperature at a speed of 1500r / min in a closed reaction kettle for 45min to obtain mixture A;

[0044] S2. Stir 150g of white carbon black at a speed of 60r / min, slowly drop the mixture A into the stirring silica gel G within 30min, continue to stir for 30min after the dripping, until there is no obvious liquid on the surface of the solid adsorbent, the mixture B is obtained ;

[0045] S3. Weigh 15 g of sodium alginate and add it into 200 g of water, stir at room temperature for 30 min at a speed of 500 r / min to obtain a transparent colloid, namely mixture C, and the viscosity of mixture C is 11527 mPa·s.

[0046] S4. Weigh 30 g of calcium chloride and add it into 60 g of water, stir at ...

Embodiment 3

[0051] Prepare the allicin sustained-release microcapsule preparation according to the following steps:

[0052] S1. Weigh 100 g of allicin raw material and 30 g of polyglycerol fatty ester in sequence according to the proportion, add it into 70 g of purified water, and shear, stir and emulsify at room temperature at a speed of 2000 r / min in a closed reactor for 20 minutes to obtain mixture A;

[0053] S2. Stir 200g of attapulgite at a speed of 60r / min, slowly drop the mixture A into the stirring silica gel G within 30min, continue stirring for 30min after the dripping is completed, until there is no obvious liquid on the surface of the solid adsorbent, the mixture B is obtained ;

[0054] S3. Weigh 20 g of sodium alginate and add it into 250 g of water, stir at room temperature at a speed of 500 r / min for 45 min to obtain a transparent colloid, namely mixture C, and the viscosity of mixture C is 12046 mPa·s.

[0055] S4. Weigh 40 g of calcium chloride and add it to 80 g of w...

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Abstract

The invention discloses a method for preparing an allicin sustained-release microcapsule preparation by a carrier adsorption and homogeneous precipitation coupling method. The allicin sustained-release microcapsule preparation is characterized by comprising the following components in percentage by mass: 0.1-20% of allicin, 2-50% of a solid adsorbent, 0.1-10% of an emulsifier, and 20-70% of calcium alginate. The emulsifier is selected from at least one of polysorbate-80, sucrose ester and polyglycerol fatty ester; and the solid adsorbent is selected from at least one of silica gel G, white carbon black and attapulgite. A calcium alginate coating on the outer layer of an allicin sustained-release microcapsule preparation particle provided by the invention is not liable to dissolve in water,pressure-resistant, wear-resistant and not liable to break, the allicin can be slowly released only after the coating is damaged in gastric acid, the calcium alginate coating powerfully prevents volatilization and oxidation loss of the allicin, and the bioavailability of the allicin is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of preparation of animal medicines, and in particular relates to a method for preparing allicin sustained-release microcapsule preparations by coupling carrier adsorption and uniform precipitation. Background technique [0002] Garlic (Allium sativum L.) is the bulb of the Allium plant garlic, which has been a medicinal and edible plant since ancient times. Garlic contains a variety of chemical components, mainly including sulfur-containing organic compounds and saponins, among which sulfur-containing organic compounds are important active substances. Allicin (Allicin) is an organosulfur compound extracted from garlic, also present in onions and other plants of the Allium family, and its scientific name is diallyl thiosulfinate. Allicin is a fat-soluble organic sulfide produced by activating alliinase and decomposing alliin when garlic cells are damaged. According to the number of sulfur atoms, it can be di...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/52A61K47/36A61K31/255A61P31/04A61P29/00A61P35/00A61P39/06A61P37/04A61P9/00
CPCA61K9/5036A61K31/255A61P31/04A61P29/00A61P35/00A61P39/06A61P37/04A61P9/00
Inventor 乔宽陶正国林劲冬
Owner GUANGZHOU LEADER BIO TECH
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