Synthesis method of polysorbate 80 with low polysorbitol content

Abstract

A synthesis method of polysorbate 80 with low polysorbitol content comprises the steps: (1) preparation of sorbitan: dehydrating sorbitol in a vacuum state under the action of a catalyst to prepare sorbitan; (2) separation of polysorbitol in sorbitan: mixing sorbitan, low-carbon alcohol and an adsorbent, then carrying out heating dissolving, carrying out cooling crystallization and drying in vacuum to obtain refined sorbitan; (3) preparation of sorbitan oleate: mixing the refined sorbitan with oleic acid, and carrying out an esterification reaction under the action of a catalyst, to prepare sorbitan oleate; and (4) synthesis of polysorbate 80: carrying out an addition polymerization reaction of sorbitan oleate and about 20 moles of ethylene oxide under the action of a catalyst to prepare polysorbate 80. Polysorbitol in the polysorbate 80 is removed, the hydroxyl value of refined sorbitan is controlled, the relative stability of the components is ensured, the content of the polysorbitol(<0.1%) is reduced and the biological safety of the polysorbate 80 product is improved.

Description

Technical field [0001] The invention relates to a method for synthesizing polysorbate 80 with oligosorbitol content, and belongs to the technical field of chemical synthesis. technical background [0002] Polysorbate 80 (also known as Tween-80, polyoxyethylene (20) sorbitan monooleate) is widely used as a dispersant, thickener, etc. in the fields of medicine, biological products, food, cosmetics and chemicals. , Antifogging agent, penetrant, etc. In recent years, the product has been used in a large amount of biological products, especially in the production of vaccines. [0003] The synthetic routes of polysorbate 80 reported in the literature can be summarized as follows: [0004] Route 1: First take sorbitol as the raw material, directly carry out esterification reaction with oleic acid under the action of acid, and carry out intramolecular dehydration reaction to prepare Span 80; or first carry out dehydration reaction of sorbitol under alkali catalysis to prepare loss Water so...

AI Technical Summary

Problems solved by technology

[0006] In above-mentioned route one, sorbitol will inevitably produce polysorbate when dehydration and esterification, usually more than 5%, if directly used in the synthesis of polysorbate 80 without separation, will generate larger The ethylene oxide polymer of the polysorbate of molecule and oleic acid ester thereof, the existence of this kind of macromolecular substance has had a strong impact on the safety that polysorbate 80 uses; After the esterification reaction of sorbitol and oleic acid is complete, further dehydration reaction of sorbitol hydroxyl group is required to control the hydroxyl value of Span 80 within a certain range, which prolongs the reaction time

[0007] The above-mentioned route two can solve the residual problem of polysorbate in polysorbate 80 by controlling the composition of different degrees of sorbitan, but it is necessary to separately refine and purify sorbitol with different degrees of dehydration, the process is complicated, and there are many steps. Large-scale production efficiency and low cost