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A kind of refining process and application of perilla oil for injection with low sterol

A technology of saffron oil and injection, applied in the field of medicine, can solve problems such as being difficult to effectively separate, and achieve the effects of good intravenous nutrition support, promotion of recovery, and improvement of disproportionate proportions.

Active Publication Date: 2018-11-13
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the similar physical and chemical properties of phytosterol esters and triglycerides, it is difficult to achieve effective separation by common physical and chemical methods. How to effectively reduce the content of phytosterols in oils for injection is a difficult task

Method used

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  • A kind of refining process and application of perilla oil for injection with low sterol
  • A kind of refining process and application of perilla oil for injection with low sterol
  • A kind of refining process and application of perilla oil for injection with low sterol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] (1) Degumming: Preheat 1000g perilla oil to 55°C, stir, add 0.3% phosphoric acid by weight of perilla oil, stir rapidly for 25 minutes, slow down the stirring speed, add 5% perilla oil to a concentration of 2 % of lye at the same temperature, then add 5% perilla oil weight of purified water at the same temperature, continue to stir for 15 minutes until the pH of the oil foot is 5, and centrifuge at a speed of 3500 rpm for 10 minutes to remove the phospholipids in the crude oil , transfer the supernatant clear oil, and vacuum dehydrate to obtain degummed oil.

[0054] (2) Deacidification: Preheat the degummed oil to 65°C, under slow stirring, add the lye at the same temperature with the superalkaline amount of 0.05% of the weight of the degummed oil and the concentration of 2%g / mL at the same temperature, react for 25min, add Preheat saturated sodium chloride solution with 7.5% degummed oil weight, continue to stir for 8 minutes, and then centrifuge at 4000 rpm for 10 mi...

Embodiment 2

[0060](1) Desterolization: Add n-hexane equal to the weight of perilla oil to 1000g perilla oil to dilute it, stir and mix evenly, and slowly add to the vertical melting point of 100 mesh column chromatography silica gel covered with 0.2 times the weight of perilla oil In the funnel, carry out decompression elution, so that the free sterols are fully absorbed by the adsorbent, the oil flows out with the eluent, and the eluent is concentrated to obtain the free sterol oil, and the free sterol oil is decomposed by n-hexane with twice the weight of perilla oil. Dilute the oil, stir and mix evenly, slowly add it to a sand core funnel covered with 100-mesh column chromatography silica gel twice the weight of perilla oil for suction filtration, and use a volume ratio of 10:1 of n-hexane twice the weight of perilla oil The eluent composed of alkane and isopropanol mixed solvent was used to elute the inner grease of silica gel, and the eluent was concentrated by rotary evaporation to o...

Embodiment 3

[0068] (1) Degumming: Preheat 1000g perilla oil to 60°C, stir, add phosphoric acid with an oil weight of 0.3%, stir rapidly for 25 minutes, then slow down the stirring speed, add 3.5% oil with a concentration of 2% at the same temperature Then add purified water at the same temperature with an oil weight of 3%, and continue to stir for 12 minutes until the pH value of the oil foot is 5. Centrifuge at a speed of 4000 rpm for 5 minutes to remove the phospholipids in the crude oil, transfer the upper layer of clear oil, and vacuum Dehydration yields degummed oil.

[0069] (2) Deacidification: preheat the degummed oil to 60°C, under slow stirring, add the lye at the same temperature with the superalkaline amount equal to 0.04% of the weight of the degummed oil and the concentration of 2% g / mL at the same temperature, react for 15 minutes, add Preheated saturated sodium chloride solution with degummed oil weight 7.5%, continue to stir for 8 minutes, then centrifuge at 4000 rpm for ...

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Abstract

The invention relates to perilla oil and particularly relates to a refining process and use of perilla oil for low sterol injection, belonging to the technical field of medicines. The refining process comprises the following steps: degumming, deacidification, decoloration, deodorization, low-temperature aseptic filtration and sterol removal, wherein the sterol removal step is carried out after the deacidification step or the decoloration step, or the steps of degumming, deacidification, decoloration, deodorization and low-temperature aseptic filtration are carried out after perilla oil is subjected to sterol removal; the sterol removal step comprises the procedures of adding a solvent into perilla oil and deacidified or decolorized products, stirring to uniformly mix, slowly adding diluted grease into a decompression device which is paved with an adsorbent, carrying out reduced pressure elution to adequately adsorb free sterols by the adsorbent and enable grease to flow out with elution liquid, and concentrating elution liquid, so as to obtain free sterol removed oil, wherein the solvent is one or more of normal hexane, cyclohexane, petroleum ether, isopropanol, ethanol and methanol. By integrating a phytosterol removal technique into the refining process of perilla oil for injection, most free sterols and sterol esters in perilla oil can be effectively removed.

Description

technical field [0001] The invention relates to perilla oil, in particular to a refining process and application of perilla oil for low-sterol injection, belonging to the technical field of medicine. Background technique [0002] Parenteral nutrition is an effective treatment for patients who are unable, inadequate, or contraindicated to take oral or enteral nutrition. The initial parenteral nutrition preparations are mainly glucose and amino acid infusions. Although they can provide sufficient energy to the body in time, long-term use alone will cause a series of adverse reactions, including hyperglycemia, lack of essential fatty acids, etc. Can lead to secondary adverse reactions. In 1961, Swedish scientists used soybean oil and egg yolk lecithin to successfully develop the fat emulsion for intravenous injection—Intralipid for the first time. It was used for parenteral nutrition and quickly became irreplaceable in parenteral nutrition due to its unique advantages. compon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C11B3/00A61K36/535A61K9/107A61P17/02A61P1/12A61P31/00A61P3/02A61K131/00
Inventor 唐星尹湉杨振华任天阳何海冰张宇刘东春徐晖蔡翠芳
Owner SHENYANG PHARMA UNIVERSITY
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