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A kind of osteosynthetic tablet and preparation method thereof

A technology for bone-setting tablets and prescriptions, which is used in bone diseases, pharmaceutical formulations, and medical preparations with inactive ingredients, etc. Availability, shortened disintegration time, low impurity content

Active Publication Date: 2018-03-23
河北百善药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process is simple and rough, contains more impurities, the extraction rate of active ingredients is low, and the effect is not good
[0004] Chinese patent application 201210388907.0 provides a new preparation method of bone joints, Chuanxiong, Angelica, Vinegar-roasted Frankincense, Vinegar-roasted Myrrh using supercritical CO 2 Extraction technology is used for extraction, and Aconitum aconitum and calcined natural copper are extracted by microwave extraction technology. The extraction rate of ferulic acid in this method is significantly improved. However, this method does not see the improvement of other active ingredients, and microwave extraction uses ethanol of equal concentration extraction, the extraction rate is still limited
[0005] Secondly, there are still problems such as poor taste, slow drug effect time, poor product appearance and poor effect in clinical practice.

Method used

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  • A kind of osteosynthetic tablet and preparation method thereof
  • A kind of osteosynthetic tablet and preparation method thereof
  • A kind of osteosynthetic tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027]

[0028] Preparation:

[0029] (1) Extraction of volatile oil

[0030] Get the prescription amount of vinegar-roasted frankincense, vinegar-roasted myrrh, and angelica raw materials and mix them into coarse powder, pass through a 40-mesh sieve, add 0.5% cellulase and pectinase (1.5:1) of the weight of raw materials for the first time , stir evenly, add 6 times of water, keep the temperature at 40°C, and pH 4.0, carry out enzymatic hydrolysis treatment for 1 hour, then add 0.7% cellulase and pectinase (1.5:1) of the weight of the raw material drug, and then enzymatically Put it into a water distiller device after decomposing for 1 hour, carry out steam distillation extraction for 5 hours, and collect volatile oil;

[0031] (2) Continuous dynamic ethanol concentration extraction

[0032] Grind Rhizoma Chuanxiong, Zhichuanwu, Calcined Natural Copper, and No. 4 copper powder into coarse powder and mix them, pass through a 40-mesh coarse sieve, combine the medicinal res...

Embodiment 2

[0039]

[0040] Preparation:

[0041] (1) Extraction of volatile oil

[0042] Get the prescription amount of vinegar-roasted frankincense, vinegar-roasted myrrh, and angelica raw materials and mix them into coarse powder, pass through a 40-mesh sieve, add 0.5% cellulase and pectinase (1.5:1) of the weight of raw materials for the first time , stir evenly, add 8 times of water, keep the temperature at 50°C, and pH 5.0, carry out enzymatic hydrolysis treatment for 1 hour, then add 0.7% cellulase and pectinase (1.5:1) of the weight of the raw material drug, and then enzymatically After decomposing for 1 hour, put it into a water distiller device, carry out steam distillation and extraction for 4 hours, and collect the volatile oil;

[0043] (2) Continuous dynamic ethanol concentration extraction

[0044] Grind Rhizoma Chuanxiong, Zhichuanwu, Calcined Natural Copper, and No. 4 copper powder into coarse powder and mix them, pass through a 40-mesh coarse sieve, combine the medi...

Embodiment 3

[0051]

[0052] Preparation:

[0053] (1) Extraction of volatile oil

[0054] Get the prescription amount of vinegar-roasted frankincense, vinegar-roasted myrrh, and angelica raw materials and mix them into coarse powder, pass through a 40-mesh sieve, add 0.5% cellulase and pectinase (1.5:1) of the weight of raw materials for the first time , stir evenly, add 8 times of water, keep the temperature at 45°C, and pH 4.5, carry out enzymatic hydrolysis treatment for 1 hour, then add 0.7% cellulase and pectinase (1.5:1) of the weight of the raw material drug, and then enzymatically Put it into a water distiller device after decomposing for 1 hour, carry out steam distillation extraction for 6 hours, and collect volatile oil;

[0055] (2) Continuous dynamic ethanol concentration extraction

[0056] Grind Rhizoma Chuanxiong, Zhichuanwu, Calcined Natural Copper, and No. 4 copper powder into coarse powder and mix them, pass through a 40-mesh coarse sieve, combine the medicinal res...

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PUM

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Abstract

The invention discloses a preparation method of bone joint slices and a product thereof. It uses Chuanxiong, Zhichuanwu, Angelica, vinegar-roasted frankincense, vinegar-roasted myrrh, calcined natural copper, and No. 4 copper powder as raw materials. The method is as follows: 1) take vinegar-roasted frankincense, vinegar-roasted myrrh, and angelica to extract volatile oil; 2) extract chuanxiong, Zhichuanwu, calcined natural copper, and No. 3) Use vacuum decompression concentration process to concentrate the extract; 4) Mix the above-mentioned extract, volatile oil and suitable auxiliary materials evenly to make granules, make soft materials, granulate, dry, and compress into tablets. The invention improves the original preparation method, and under the condition of extracting more active ingredients, the content of the active ingredients is enhanced, the dissolvability of the tablet is good, the bioavailability is high, and the curative effect is remarkable.

Description

Technical field: [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a bone joint tablet with the functions of dispelling blood stasis, promoting blood circulation and relieving pain and a preparation method thereof. technical background: [0002] Fracture is the most common traumatic disease in orthopedic surgery. Because the natural healing process of bone takes a long time, it seriously affects the life and work of patients. Therefore, how to quickly promote fracture healing has always been the focus of orthopedic research. Jiegu Tablets are a combination of 7 traditional Chinese medicines: Chuanxiong, Zhichuanwu, Angelica, Vinegar-roasted Frankincense, Vinegar-roasted Myrrh, Calcined Natural Copper, and No. 4 Copper Powder. It is commonly used in traditional Chinese medicine for trauma and orthopedics. It has the functions of dispersing blood stasis, promoting blood circulation and relieving pain, and is ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/714A61K47/36A61P19/08A61P29/00A61K33/26A61K33/34
Inventor 韩志强
Owner 河北百善药业有限公司