A method for hydrophilic modification of hydroxyapatite single crystal nanorods
A hydroxyapatite, single-crystal nanotechnology, applied in single-crystal growth, single-crystal growth, chemical instruments and methods, etc., can solve problems such as hydrophilicity limitations, and achieve stable product quality, good reproducibility, and raw materials. Inexpensive and accessible effects
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Embodiment 1
[0023] In a 100mL flask, add the above-mentioned 800mg hydrophobic hydroxyapatite nanorods, 200mg riboflavin sodium phosphate, and 50mL acetone solution, and reflux at 60°C for 6-8 h to obtain sample A; then use the phosphoric acid ligand in sample A Synthesize a new chain transfer agent with the functional group (-OH) on the chain transfer agent CTA, reaction conditions: 600mg product A and 108mg S-isocyanate-N-ethyl-N'-phenyldithiocarbamate (CTA) Use N,N'-dicyclohexylcarbodiimide (DCC, 1.00g) as a dehydrating agent, 4-dimethylaminopyridine (DMAP, 200mg) as a catalyst to form a new chain transfer agent, and react at room temperature for 18- 24 h is recorded as sample B. Finally, 100mg of sample B was used as a new chain transfer agent, 12mg of azobisisobutyronitrile (AIBN) as a chain initiator, 1.00g of hydrophilic polymer polyethylene glycol methacrylate (PEGMA) as a monomer, tetrahydrofuran As a solvent, react for 24 h under nitrogen atmosphere, and collect samples.
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Embodiment 2
[0026] In a 100mL flask, add 800mg hydrophobic hydroxyapatite nanorods, 200mg riboflavin sodium phosphate, and 50mL acetone solution, and reflux at 60°C for 6-8 h to obtain sample A; The functional group (-OH) of the chain transfer agent CTA to synthesize a new chain transfer agent, reaction conditions: 600mg product A and 108mg S-isocyanate-N-ethyl-N'-phenyldithiocarbamate ( CTA) Use N,N'-dicyclohexylcarbodiimide (DCC, 1.00g) as a dehydrating agent, 4-dimethylaminopyridine (DMAP, 200mg) as a catalyst to form a new chain transfer agent, and react at room temperature for 18-24 h is recorded as sample B. Finally, 100mg of sample B was used as a new chain transfer agent, 12mg of azobisisobutyronitrile (AIBN) as a chain initiator, 2.00g of hydrophilic polymer polyethylene glycol methacrylate (PEGMA) as a monomer, tetrahydrofuran As a solvent, react for 24 h under nitrogen atmosphere, and collect samples.
Embodiment 3
[0028] In a 100mL flask, add 800mg hydrophobic hydroxyapatite nanorods, 200mg riboflavin sodium phosphate, and 50mL acetone solution, and reflux at 60°C for 6-8 h to obtain sample A; The functional group (-OH) of the chain transfer agent CTA to synthesize a new chain transfer agent, reaction conditions: 600mg product A and 108mg S-isocyanate-N-ethyl-N'-phenyldithiocarbamate ( CTA) Use N,N'-dicyclohexylcarbodiimide (DCC, 1.00g) as a dehydrating agent, 4-dimethylaminopyridine (DMAP, 200mg) as a catalyst to form a new chain transfer agent, and react at room temperature for 18-24 h is recorded as sample B. Finally, the sample 100mg B was used as a new chain transfer agent, 12mg azobisisobutyronitrile (AIBN) was used as a chain initiator, 1.00g hydrophilic polymer phospholipid was used as a monomer, tetrahydrofuran was used as a solvent, and the reaction was carried out under nitrogen atmosphere for 24 h. Collect samples.
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