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A kind of degradable artificial skin support and preparation method thereof

A technology of artificial skin and preparation steps, applied in medical science, prosthesis, etc., can solve problems such as complicated operation, and achieve the effect of simple operation and less time

Active Publication Date: 2018-05-18
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at the same time, in the process of "evolution" of the previous chitosan-sodium alginate composite scaffold material, although many shortcomings have been overcome, the operation has become complicated

Method used

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  • A kind of degradable artificial skin support and preparation method thereof
  • A kind of degradable artificial skin support and preparation method thereof
  • A kind of degradable artificial skin support and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Weigh 0.5g of chitosan and dissolve it in 100mL of acetic acid solution with a mass fraction of 5%, add chitosan powder and acetic acid into a beaker with a capacity of 50mL, seal the mouth of the beaker with a wax film, and rotate at a speed of 500r / min, the temperature Dissolve completely at 40°C to a transparent and clear solution to make a 0.005g / mL chitosan solution, and prepare a 0.05g / mL CaCl solution with a pure aqueous solution 2 saline solution, chitosan solution and CaCl 2 The salt solution is mixed in a 2:1 volume ratio to form CaCl 2 solution and a mixed solution of chitosan-acetic acid solution. Weigh 0.9g of sodium alginate powder into a 50mL beaker, add 30mL of pure water, control the temperature at 50°C, and dissolve at 500r for 2h to prepare a 0.03g / mL sodium alginate solution. Add 2 mL of sodium alginate solution to a petri dish with a diameter of 10 cm, so that the sodium alginate solution evenly covers the bottom of the petri dish, and after stand...

Embodiment 2

[0024] Weigh 1g of chitosan and dissolve it in 100mL of acetic acid solution with a mass fraction of 5%, add chitosan powder and acetic acid into a beaker with a capacity of 50mL, seal the mouth of the beaker with a wax film, and rotate at a speed of 500r / min. Dissolve completely at 50°C to a transparent and clear solution to make a 0.01g / mL chitosan solution, and prepare a 0.05g / mL CaCl solution with a pure aqueous solution 2 saline solution, chitosan solution and CaCl 2 The salt solution is mixed in a 2:1 volume ratio to form CaCl 2 solution and a mixed solution of chitosan-acetic acid solution. Weigh 0.9g of sodium alginate powder into a 50mL beaker, add 30mL of pure water, control the temperature at 50°C, and dissolve at 500r for 2h to prepare a sodium alginate solution with a mass fraction of 0.03g / mL. Add 2 mL of sodium alginate solution to a petri dish with a diameter of 10 cm, so that the sodium alginate solution evenly covers the bottom of the petri dish, and after ...

Embodiment 3

[0026] Weigh 2.0g of chitosan and dissolve it in 100mL of acetic acid solution with a mass fraction of 5%, add chitosan powder and acetic acid into a beaker with a capacity of 50mL, seal the mouth of the beaker with a wax film, and rotate at a speed of 300r / min, the temperature Dissolve completely at 60°C to a transparent and clear solution to prepare 0.02g / mL chitosan solution, and prepare 0.05g / mL CaCl with pure aqueous solution 2 saline solution, chitosan solution and CaCl 2 The salt solution is mixed in a 2:1 volume ratio to form CaCl 2solution and chitosan acetic acid solution mixed solution 6mL. Weigh 0.9g of sodium alginate powder into a 50mL beaker, add 30mL of pure water, control the temperature at 50°C, and dissolve at 500r for 2h to prepare a 0.03g / mL sodium alginate solution. Add 2 mL of sodium alginate solution to a petri dish with a diameter of 10 cm, so that the sodium alginate solution evenly covers the bottom of the petri dish, and after standing for 10 minu...

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Abstract

The invention provides a degradable artificial skin scaffold and a preparation method thereof. The preparation method comprises steps as follow: preparing a chitosan acetate solution firstly, and preparing a sodium alginate solution and a CaCl2 solution; preparing a mixed solution of the CaCl2 solution and the chitosan acetate solution; adding the sodium alginate solution to a container with a planar bottom surface, forming a smooth and flat solution layer, and adding the mixed solution; placing the container into a vacuum drying chamber after reaction at the room temperature, and performing vacuum drying to obtain the degradable artificial skin scaffold. The degradable artificial skin scaffold meets requirements of skin tissue engineering scaffold materials and has good strength and toughness.

Description

technical field [0001] The invention belongs to the technical field of biological scaffolds, and mainly relates to a degradable artificial skin scaffold and a preparation method thereof, and is especially suitable for cultivating skin cells to prepare a degradable artificial skin. Background technique [0002] The importance of the skin to the human body is self-evident. One is because it is the largest organ in the human body, and the other is because it has many important functions, the most important of which is the barrier function. In addition, it also has many important functions such as excretion, immunity, feeling external stimuli, and regulating body temperature. . But in today's life, when the area of ​​skin damage and defect is too large due to accidents and diseases, especially the large area of ​​skin damage caused by burns and scald accidents, the human body cannot completely heal itself only by itself. Artificial skin came into being under this current situat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/58
Inventor 王婷崔青刘旭喻曦子郭悦彤陈战
Owner SOUTHEAST UNIV