A chiral tridentate pnn ligand and its application in asymmetric hydrogenation reactions

An asymmetric and chiral technology that can be used in asymmetric synthesis, preparation of organic compounds, organic compound/hydride/coordination complex catalysts, etc., and can solve problems such as complex synthesis routes
CN105153229BActive Publication Date: 2017-12-08SHENZHEN CATALYS SCI & TECH CO LTD +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHENZHEN CATALYS SCI & TECH CO LTD
Publication Date
2017-12-08

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Abstract

The invention discloses a class of chiral tridentate nitrogen phosphine ligand and its application in asymmetric hydrogenation and similar reactions. The tridentate nitrogen phosphine ligand disclosed in the present invention is the first chiral oxazoline-containing tridentate nitrogen phosphine ligand, and has been successfully applied to the hydrogenation reaction of ketones and imide salts and similar reactions with high efficiency and high selectivity . Compared with other ligands, the synthetic route is simple, the yield is high, and it is more environmentally friendly. In addition, the metal complexes of this type of ligand not only show better selectivity in asymmetric hydrogenation reactions, but also show higher conversion numbers . The iridium complex of the chiral tridentate nitrogen phosphine ligand of the present invention has successfully asymmetrically reduced β-ketone lipids to β-alcohol lipids (raw materials for the synthesis of molecular drugs duloxetine and atomoxetine), and α ‑Hydroxyacetophenone asymmetrically hydrogenates α‑hydroxyphenylethanol, and asymmetrically hydrogenates acetophenone to phenylethyl alcohol, which is of great significance for the production of the pharmaceutical industry.
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Description

technical field

[0001] The invention relates to a chiral tridentate nitrogen phosphine ligand and its application in asymmetric hydrogenation reaction, which belongs to the field of fine chemical industry. Background technique

[0002] Chiral compounds are widely used in pesticides, medicine, food, materials, fine chemicals and other fields, and are of great significance. With the improvement of living standards, people's demand for medicine and fine chemical products has greatly increased. In 2010, the global drug production value reached 880 billion US dollars, and generic drugs reached 103 billion US dollars. As the third largest pharmaceutical market in the world, China contains huge market opportunities. Therefore, scientists need to explore more efficient and environmentally friendly methods to design and selectively synthesize monochiral molecules. Asymmetric catalytic reaction is the most economical and efficient way to synthesize chiral compounds, and a large amo...

Claims

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