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Hepatitis C virus inhibitors

A kind of cyclopropane, compound technology, applied in functional compound, inhibit NS3 protease function field

Inactive Publication Date: 2015-12-16
BRISTOL MYERS SQUIBB CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, even with experimental regimens involving the combination of PEGylated interferon-alpha and ribavirin, a substantial fraction of patients did not experience sustained reductions in viral load

Method used

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  • Hepatitis C virus inhibitors
  • Hepatitis C virus inhibitors
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Embodiment Construction

[0167] The application will now be described in terms of certain embodiments, which are not intended to limit the scope of the application. On the contrary, the application covers all alternatives, modifications and equivalents as may be included within the scope of the claims. Accordingly, the following examples, including specific embodiments, will illustrate one implementation of the present application, where it should be understood that the examples are intended to illustrate certain embodiments and are presented to provide information believed to be relevant to the operation thereof. and conceptual aspects of the most useful and accessible descriptions.

[0168] The abbreviations used in the present application, especially including the abbreviations used in the following illustrative schemes and examples, are well known to those skilled in the art. Some of the abbreviations used are as follows: LAH for lithium aluminum hydride; MsCl for methanesulfonyl chloride; Ph for...

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Abstract

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application 61 / 774,136, filed March 7, 2013, which is hereby incorporated by reference in its entirety. technical field [0003] The present application relates generally to antiviral compounds, and more particularly to compounds, combinations comprising said compounds, which inhibit the function of the NS3 protease (also referred to herein as "serine protease") encoded by hepatitis C virus (HCV) Substances and methods for inhibiting NS3 protease function. Background technique [0004] HCV is a major human pathogen, infecting approximately 170 million people worldwide—approximately five times the number of human immunodeficiency virus type 1 infections. A substantial fraction of these HCV-infected individuals develop severe progressive liver disease, which includes cirrhosis and hepatocellular carcinoma. [0005] Currently, the most effective HCV therapy uses ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/103C07K5/10A61P31/14A61K38/00
CPCC07K5/1002C07K5/1013A61K38/07A61K38/06A61P31/14A61P31/22A61K45/06C07K5/081
Inventor P·纳加拉克施米K·萨库南K·V·伦杜钦塔拉P·M·斯科拉
Owner BRISTOL MYERS SQUIBB CO
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