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A kind of stabilizer and stabilizing method for extracting solution of honeysuckle

A stabilizer, honeysuckle technology, applied in the field of pharmacy, can solve the problems of decreased chlorogenic acid content, large pH changes, unstable storage, etc., to achieve the effect of extending shelf life, stable product content, and clear appearance

Active Publication Date: 2018-07-17
王志敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of unstable storage, large pH change, gradual decrease of chlorogenic acid content and turbid appearance in the existing honeysuckle extract solution, and provides a stabilizer and stabilization method for the extract solution of honeysuckle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In 1mL honeysuckle extract solution, add ethanol until the alcohol degree is 60-70%, then cool down, recover ethanol after filtration, then add other adjustment components, and then adjust the pH value to 5 with sodium hydroxide.

[0017] Observation table 1,

[0018] Table 1

[0019]

[0020] As can be seen from Table 1, when the direct pH of the honeysuckle extraction solution is adjusted to 4-6, the pH of the solution gradually decreases as the storage time prolongs, from 5.09 to 4.03, and the content of chlorogenic acid in the solution increases from 525 to 4.03. Reduced to 176, the appearance of the solution gradually changed from brownish-yellow and clear to brown, and a large number of massive precipitates were formed at the bottom of the solution.

Embodiment 2

[0022] Add 10 mg of pea maltodextrin and 10 mg of β-cyclodextrin to 1 mL of honeysuckle extract solution, mix until uniform, add ethanol until the alcohol degree is 60-70%, then cool down, recover ethanol after filtration, and then add other adjustment components, Then adjust the pH value to 5 with sodium hydroxide.

[0023] Observation table 2,

[0024] Table 2

[0025]

Embodiment 3

[0027] Add 15 mg of pea maltodextrin, 5 mg of β-cyclodextrin, and 5 mg of hydroxypropyl-β-cyclodextrin to 1 mL of honeysuckle extract solution, mix until uniform, add ethanol until the alcohol degree is 70-75%, and then cool down. After filtering with a 0.2 μm microporous membrane, the ethanol is recovered, and then other adjustment components are added, and then the pH is adjusted to 4-4.5 with sodium hydroxide.

[0028] Observed in Table 3,

[0029] table 3

[0030]

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Abstract

The invention discloses a stabilizer and a stabilizing method for a honeysuckle extracted solution, belongs to the technical field of pharmacy, and relates to extraction of medicinal materials, namely, honeysuckle. The problems that an existing honeysuckle extracted solution is instable in storage and turbid in appearance, the content of chlorogenic acid is gradually reduced, and PH is changed are solved. The stabilizer for the honeysuckle extracted solution is prepared from pea maltodextrin, beta-cyclodextrin and / or hydroxypropyl-beta-cyclodextrin. Cyclodextrin and pea maltodextrin are mixed to serve as the stabilizer, the advantages of being high in solubility and solubilization of cyclodextrin cavities and pea maltodextrin are combined, the stabilizer is mixed with the honeysuckle extracted solution according to a certain proportion, it can be guaranteed that the PH value of the solution is basically unchanged, the product content is stable, and the appearance is kept clear.

Description

technical field [0001] The invention belongs to the technical field of pharmacy and relates to the extraction of honeysuckle medicinal materials, in particular to a stabilizer and a stabilizing method for the extraction solution of honeysuckle. Background technique [0002] Honeysuckle, also known as honeysuckle, is the dry flower buds or flowers of the same genus Lonicera and the same plants. The name "Honeysuckle" comes from "Compendium of Materia Medica". It is named honeysuckle because it first blooms white and then turns yellow. Sweet and cold in nature, heat-clearing and toxic substances removing, dispelling wind-heat, used for treating carbuncle sores, sore throat, erysipelas, heat-toxin bloody dysentery, wind-heat cold, febrile disease fever. Honeysuckle has a long history of medicinal use. Our ancestors began to use it to prevent and treat diseases as early as 3000 years ago. "Shen Nong's Materia Medica" records: "Honeysuckle is cold in nature and sweet in taste. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/40A61K47/36A61K36/355
Inventor 贺婕张爱荣王志敏姜建芬
Owner 王志敏
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