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Stabilizer and stabilizing method for honeysuckle extracted solution

A honeysuckle and stabilizer technology, applied in the field of pharmacy, can solve the problems of decreased chlorogenic acid content, unstable storage, large pH changes, etc., and achieve the effects of stable product content, clear appearance, and extended shelf life

Active Publication Date: 2016-01-13
王志敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of unstable storage, large pH change, gradual decrease of chlorogenic acid content and turbid appearance in the existing honeysuckle extract solution, and provides a stabilizer and stabilization method for the extract solution of honeysuckle

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In 1mL of honeysuckle extraction solution, add ethanol to 60-70% alcohol, then cool down, recover the ethanol after filtration, then add other adjusting components, and adjust the pH to 5 with sodium hydroxide.

[0017] Observe Table 1,

[0018] Table 1

[0019]

[0020] It can be seen from Table 1 that when the PH of the honeysuckle extraction solution is directly adjusted to 4-6, the pH of the solution gradually decreases with the extension of storage time, from 5.09 to 4.03, while the content of chlorogenic acid in the solution decreases from 525 Reducing to 176, the appearance of the solution gradually changed from brownish yellow to brownish brown, and a large amount of lumpy precipitates formed at the bottom of the solution.

Embodiment 2

[0022] In 1mL of honeysuckle extract solution, add 10mg of pea maltodextrin and 10mg of β-cyclodextrin, mix until uniform, add ethanol to 60-70% of the alcohol, then chill, recover the ethanol after filtration, and then add other adjusting ingredients. Then adjust the pH to 5 with sodium hydroxide.

[0023] Observe Table 2,

[0024] Table 2

[0025]

Embodiment 3

[0027] In 1mL of honeysuckle extract solution, add 15mg of pea maltodextrin, 5mg of β-cyclodextrin, and 5mg of hydroxypropyl-β-cyclodextrin, mix until uniform, add ethanol to 70-75% alcohol and then let it sink. After filtering with a 0.2μm microporous membrane, the ethanol is recovered, and then other adjusting ingredients are added, and then the pH is adjusted to 4-4.5 with sodium hydroxide.

[0028] Observe Table 3,

[0029] table 3

[0030]

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PUM

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Abstract

The invention discloses a stabilizer and a stabilizing method for a honeysuckle extracted solution, belongs to the technical field of pharmacy, and relates to extraction of medicinal materials, namely, honeysuckle. The problems that an existing honeysuckle extracted solution is instable in storage and turbid in appearance, the content of chlorogenic acid is gradually reduced, and PH is changed are solved. The stabilizer for the honeysuckle extracted solution is prepared from pea maltodextrin, beta-cyclodextrin and / or hydroxypropyl-beta-cyclodextrin. Cyclodextrin and pea maltodextrin are mixed to serve as the stabilizer, the advantages of being high in solubility and solubilization of cyclodextrin cavities and pea maltodextrin are combined, the stabilizer is mixed with the honeysuckle extracted solution according to a certain proportion, it can be guaranteed that the PH value of the solution is basically unchanged, the product content is stable, and the appearance is kept clear.

Description

Technical field [0001] The invention belongs to the technical field of pharmacy, relates to the extraction of honeysuckle medicinal materials, and in particular relates to a stabilizer and a stabilization method for honeysuckle extraction solution. Background technique [0002] Honeysuckle, also known as honeysuckle, is a honeysuckle plant of the family Loniceraceae and the dry buds or flowers of the same genus. The name "Honeysuckle" comes from the "Compendium of Materia Medica". It was named honeysuckle because it was white at first and then turned yellow. It is sweet and cold in nature, clearing away heat and detoxifying, dissipating wind-heat, used for carbuncle, sore throat, erysipelas, heat toxin blood dysentery, wind-heat cold, febrile fever. Honeysuckle has a long history of medicinal use. As early as 3000 years ago, our ancestors began to use it to prevent and treat diseases. Since ancient times, it has been known as a good medicine for clearing away heat and detoxifica...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K47/36A61K36/355
Inventor 贺婕张爱荣王志敏姜建芬
Owner 王志敏
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