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43results about How to "Appearance clarification" patented technology

Dantrolene sodium freeze-dried powder injection for injection and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to a dantrolene sodium freeze-dried powder injection for injection and a preparation method thereof. The freeze-dried powder injection is prepared by freeze drying dantrolene sodium, lactobiose, a pH regulator and water for injection, wherein a mass ratio of the dantrolene sodium to the lactobiose is (1:0.5) to (1:2.5). The preparation method comprises the following steps of: adding the dantrolene sodium to the lactobiose in a prescription amount into the water for the injection, stirring, regulating the pH value to 9.0 to 10.5 by using the pH regulator, adding active carbon for injection, removing a heat source, decolorizing, filtering for decarburizing, performing fine filtering by using a filter membrane, packaging in separate bags, freezing and drying. The dantrolene sodium freeze-dried powder injection is studied on the basis of a freeze-dried process, namely the dantrolene sodium freeze-dried powder injection is cooled, heated by a small margin and is cooled again, so that the moisture of the freeze-dried product is reduced, and the freeze-dried product is high in redissolution and visible foreign matters and does not have insoluble granules. The dantrolene sodium freeze-dried powder injection for the injection is high in resolubility, clarity and stability, and low impurity content.
Owner:HAINAN JINRUI PHARMA

Method for preparing lipidosome coated with protein drugs

The invention relates to a novel method for preparing small-particle-size high-encapsulation-efficiency lipidosome coated with protein drugs and belongs to the technical field of biological medicines. The preparation process comprises the following steps: a, dissolving lipids for forming the lipidosome in an organic solvent, mixing the lipids, a protein solution and a proper amount of surfactant according to a proper ratio, and preparing a micro-emulsion phase; b, dissolving the lipids for forming the lipidosome in an organic solvent, mixing and hydrating by using water or a buffer solution or alcohol according to a proper ratio, and preparing a micellar phase; and c, mixing the micro-emulsion phase and the micellar phase, reversing the phase b into a reverse micelle, reversing the phase b again in the process of removing the organic solvent under reduced pressure, finally covering the surface of the phase a micelle with the reverse micelle, and forming the lipidosome. The encapsulated protein drug lipidosome has the average particle size of about 80nm, and the encapsulation ratio can be over 90 percent. The preparation process is simple in process, the production cost is reduced, and industrial production is easily realized.
Owner:SHENYANG PHARMA UNIVERSITY

Dantrolene sodium freeze-dried powder injection for injection and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to a dantrolene sodium freeze-dried powder injection for injection and a preparation method thereof. The freeze-dried powder injection is prepared by freeze drying dantrolene sodium, lactobiose, a pH regulator and water for injection, wherein a mass ratio of the dantrolene sodium to the lactobiose is (1:0.5) to (1:2.5). The preparation method comprises the following steps of: adding the dantrolene sodium to the lactobiose in a prescription amount into the water for the injection, stirring, regulating the pH value to 9.0 to 10.5 by using the pH regulator, adding active carbon for injection, removing a heat source, decolorizing, filtering for decarburizing, performing fine filtering by using a filter membrane, packaging in separate bags, freezing and drying. The dantrolene sodium freeze-dried powder injection is studied on the basis of a freeze-dried process, namely the dantrolene sodium freeze-dried powder injection is cooled, heated by a small margin and is cooled again, so that the moisture of the freeze-dried product is reduced, and the freeze-dried product is high in redissolution and visible foreign matters and does not have insoluble granules. The dantrolene sodium freeze-dried powder injection for the injection is high in resolubility, clarity and stability, and low impurity content.
Owner:HAINAN JINRUI PHARMA CO LTD

Globulin pasteurization process using combined protective agent

The invention relates to the technical field of human immune globulin inactivation, in particular to a globulin Pasteur inactivation process using a combined protective agent, a protein solution enriched with immune globulin is prepared with plasma as a raw material, Pasteur inactivation is performed on the protein solution, the protein solution contains sorbitol with the concentration of 300-400 g / l and glycine with the final concentration of 80-120 g / l, the pH value of the protein solution is 6.0-7.5, and the protein concentration is 10-30 g / L. According to the scheme, the technical problem that an existing pasteurization human immune globulin inactivation process is difficult to guarantee the protein yield and quality at the same time can be solved. The scheme can be applied to practical operation of production and preparation of the human immune globulin, is simple and easy to implement and low in cost, and has great popularization and application values, and the protein yield can reach 95% or above.
Owner:HUALAN BIOLOGICAL ENG CHONGQING

Soda water health-care beverage containing cyclocarya paliurus flavone and preparation method of soda water health-care beverage containing cyclocarya paliurus flavone

The invention provides a soda water health-care beverage containing cyclocarya paliurus flavone and a preparation method of soda water health-care beverage containing cyclocarya paliurus flavone. Thepreparation method comprises the following steps of S1, performing extracting on cyclocarya paliurus leaf powder twice by a leaching method, combining supernatant, performing concentrating and performing freeze drying, to obtain a cyclocarya paliurus flavone crude extract; S2, enabling the cyclocarya paliurus flavone crude extract to be made into a solution, performing filtering, performing filtering with a polyamide chromatographic column, performing concentrating, and performing freeze drying to obtain cyclocarya paliurus flavone; S3, dissolving sodium bicarbonate in purified water to obtaina sodium bicarbonate aqueous solution for later use; and S4, sterilizing the sodium bicarbonate aqueous solution, mixing the sterilized sodium bicarbonate aqueous solution with the cyclocarya paliurus flavone in a sterile environment, and performing sterile filling. The health-care beverage disclosed by the invention has the efficacy of soda water and the efficacy of reducing blood pressure, andis natural in materials, environment-friendly and healthy.
Owner:NINGBO UNIV
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