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Cancer targeting peptides for enhancing anti-cancer drug delivery and therapeutic efficencies

An anticancer drug and target peptide technology, applied in the field of cancer target peptides, can solve the problems of low binding affinity, maintaining the original binding effect, and difficulty in identifying target proteins.

Active Publication Date: 2016-01-27
ACAD SINIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the target protein recognition of the target peptide is difficult because of the low binding affinity of the peptide and the difficulty in maintaining the original binding between the target peptide and the isolated target protein in whole membrane extracts (wholemembrane extracts)

Method used

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  • Cancer targeting peptides for enhancing anti-cancer drug delivery and therapeutic efficencies
  • Cancer targeting peptides for enhancing anti-cancer drug delivery and therapeutic efficencies
  • Cancer targeting peptides for enhancing anti-cancer drug delivery and therapeutic efficencies

Examples

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Embodiment

[0065] Without intending to limit the scope of the present invention, exemplary instruments, devices, methods, and related results of specific embodiments of the present invention are described below. It should be noted that headings or subheadings may be used in the examples for the convenience of the reader and should not limit the scope of the invention in any way. Furthermore, particular theories are proposed and disclosed herein; however, they should not in any way limit the scope of the invention, whether right or wrong, so long as the invention is practiced in accordance with the invention, regardless of any particular theory or mechanism of action.

[0066] Materials and Methods

[0067] cell line. HCT116, HT29, LS174T, SW620, COLO205, A498, HTB-10, B16F10, SKOV3, PC3, U2OS, 1112SK, H184, SAS, H460, MIAPaCa2, SK-HEP-1, and Mahlavu cells were purchased from American Type Culture Collection (ATCC) , and certified by ATCC based on DNA profiling, cytogenetic analysis, an...

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Abstract

A peptide targeted conjugate is disclosed. The conjugate comprises: (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1, 2 and 3and (b) a component, to which the targeting peptide is conjugated, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, liposomes, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. The conjugate may further comprise an anti-cancer agent encapsulated within the drug delivery vehicle. Compositions and methods of treating cancer are also disclosed.

Description

technical field [0001] The present invention relates generally to cancer targeting peptides, and more particularly to cancer cell-specific peptide-target conjugates. Background technique [0002] Ligand-targeted nanoparticles with enveloped chemotherapeutics are playing an increasingly important role in cancer therapy and are expected to be the next generation treatment modality. Colorectal cancer is one of the most commonly diagnosed cancers and is the leading cause of cancer death worldwide. The current treatment of colorectal cancer has only a limited success rate. Therefore, more effective treatment modalities are urgently needed for these patients. The development of targeted drug delivery systems is essential for effective delivery of anticancer drugs to tumors. The development of novel methods for early detection and effective treatment of cancer will depend on the identification of unique biomarkers on the surface of cancer cells and the isolation of tumor-specific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K45/00C12N5/09A61P35/00
CPCA61K47/60A61K47/62A61K47/64A61K47/6911A61K31/437A61K31/704A61P35/00C07K7/08
Inventor 吴汉忠吴建勋
Owner ACAD SINIC