Preparation method of titanium dioxide nanotubes with antibacterial and anticancer properties

A technology of titanium dioxide and nanotubes, which is applied in the field of preparation of titanium dioxide nanotubes with antibacterial and anticancer properties, achieving the effects of low cost, easy availability of raw materials, and good combination effect

Active Publication Date: 2018-06-22
嘉兴慧泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the use of ruthenium complexes with antibacterial effects to improve the antibacterial effect of titanium dioxide nanotubes has not been reported. In particular, the ruthenium complexes also have anticancer effects, and can simultaneously endow titanium dioxide nanotubes with antibacterial and anticancer properties, especially Most effective against bone cancer

Method used

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  • Preparation method of titanium dioxide nanotubes with antibacterial and anticancer properties
  • Preparation method of titanium dioxide nanotubes with antibacterial and anticancer properties
  • Preparation method of titanium dioxide nanotubes with antibacterial and anticancer properties

Examples

Experimental program
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Effect test

Embodiment 1

[0028] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0029] 1) Dissolve 65 parts by weight of ruthenium trichloride hydrate and 480 parts by weight of gamma-terpinene in dehydrated alcohol of 1450 parts by weight, heat and reflux and stir for 6 hours, and leave to separate out to obtain the compound of formula (1). Compound, dichloro-bis-methylcumene diruthenium(II) dichloride;

[0030]

[0031] 2) Weigh 30 parts by weight of N 4 -Phenylthiosemicarbazide and 25 parts by weight of m-phenoxybenzaldehyde were dissolved in 900 parts by weight of dehydrated alcohol, placed in 70 ° C and heated for 4 hours, and left to separate out to obtain a compound of formula (2), That is, m-phenoxybenzaldehyde phenylenedithiosemicarbazide;

[0032]

[0033] 3) 5 parts by weight of m-phenoxybenzaldehyde phenylenedithiosemicarbazone and 5 parts by weight of dichloro-dichloro-bis-methylcumene diruthenium (I...

Embodiment 2

[0040] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0041] 1) 65 parts by weight of ruthenium trichloride hydrate hydration containing 37% ruthenium and 470 parts by weight of gamma-terpinene with a purity of 95% were dissolved in 1450 parts by weight of dehydrated alcohol, heated and stirred under reflux for 5 hours, Stand and separate out and obtain the compound with formula (1), i.e. dichloro-dichloro-bis-methylisopropylphenyl diruthenium (II);

[0042]

[0043] 2) Weigh 27 parts by weight of N 4 -Phenylthiosemicarbazide and 25 parts by weight of m-phenoxybenzaldehyde were dissolved in 870 parts by weight of dehydrated alcohol, placed in 60 ° C and heated for 3 hours, and left to separate out to obtain a compound of formula (2), That is, m-phenoxybenzaldehyde phenylenedithiosemicarbazide;

[0044]

[0045] 3) 4.5 parts by weight of m-phenoxybenzaldehyde phenylenedithiosemicarbazone ...

Embodiment 3

[0052] This scheme prepares the method for titanium dioxide nanotube with antibacterial and anticancer, comprises the following steps:

[0053]1) 70 parts by weight of ruthenium trichloride hydrate containing 37% ruthenium and 480 parts by weight of gamma-terpinene with a purity of 95% were dissolved in 1500 parts by weight of dehydrated alcohol, heated and stirred under reflux for 7 hours, Stand and separate out and obtain the compound with formula (1), i.e. dichloro-dichloro-bis-methylisopropylphenyl diruthenium (II);

[0054]

[0055] 2) Weigh 35 parts by weight of N 4 -Phenylthiosemicarbazide and 28 parts by weight of m-phenoxybenzaldehyde were dissolved in 910 parts by weight of dehydrated alcohol, placed in 80 ° C and heated for 5 hours, and left to separate out to obtain a compound of formula (2), That is, m-phenoxybenzaldehyde phenylenedithiosemicarbazide;

[0056]

[0057] 3) 5.5 parts by weight of m-phenoxybenzaldehyde phenylenedithiosemicarbazone and 6 parts...

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Abstract

The present invention discloses an antibacterial and anti-cancer titanium dioxide nano-tube preparation method, which comprises: 1) obtaining a ruthenium coordination compound; 2) dissolving the ruthenium coordination compound in ethanol; 3) soaking titanium dioxide nano-tubes in the ethanol solution, introducing nitrogen gas, and carrying out a microwave treatment; 3) carrying out standing cooling to a normal temperature, pressurizing to 20-25 Mpa, maintain for 2-3 min, reducing the pressure to normal pressure, and centrifugating for 30-60 min; and 4) removing the supernatant after the centrifugating, taking the lower layer solution and the solid, placing in an environment with a temperature of 100-120 DEG C, pressurizing to 20-25 Mpa, maintaining for 2-3 min, reducing the pressure to normal pressure, and drying for 20-26 h. With the method of the present invention, the antibacterial and anti-cancer ability of the titanium dioxide nano-tubes is strong, the harmful cell growth is effectively and durably inhibited, the medical utilization effects of the titanium dioxide nano-tubes can be effectively improved, and the significant anti-bone cancer effect is provided.

Description

technical field [0001] The invention relates to the technical field of antibacterial and anticancer titanium dioxide nanotubes, in particular to a method for preparing antibacterial and anticancer titanium dioxide nanotubes by using ruthenium complexes. Background technique [0002] In recent years, biomedical materials have developed rapidly, among which titanium metal is widely used in clinical orthopedic and dental implants. However, the associated bacterial infection problem is still a serious problem, resulting in a large number of transplant failures, causing postoperative complications for patients, and bringing about prolonged healing time and a substantial increase in costs. At present, there have been some reports on improving the antibacterial ability of titanium metal, such as using antibacterial molecules such as antibiotics to improve the antibacterial effect of titanium metal. Compared with titanium metal, titanium dioxide nanotubes can promote the formation ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/06C07F15/00
Inventor 李培源苏炜霍丽妮陈睿
Owner 嘉兴慧泉生物科技有限公司
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