Cyclodextrin modified magnetic gelatin for efficient adsorption of moxidectin and preparation method of cyclodextrin modified magnetic gelatin

A technology of moxidectin and cyclodextrin is applied in the field of cyclodextrin modified magnetic gelatin with high adsorption of moxidectin and its preparation, and can solve the problems of complicated synthesis process, harsh reaction conditions, complicated distillation and low temperature operation and the like , to achieve the effect of excellent operability, short reaction time and low preparation risk

Inactive Publication Date: 2016-02-03
武汉鸿漫源检测技术科技有限公司
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Problems solved by technology

[0005] It can be seen that the traditional method has two major disadvantages: (1) the modification of the double-layer film on the surface of the magnetic material, the synthesis process is cumbersome, the reaction conditions are harsh, and it takes a long time (at least 3 days); (2) the vinyl-modified cyclopaste Ethanol is relatively complicated, not only need to use highly toxic, flammable acryloyl chloride and easily oxidized, difficult to preserve pyridine, but also require complicated distillation and low temperature operation

Method used

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  • Cyclodextrin modified magnetic gelatin for efficient adsorption of moxidectin and preparation method of cyclodextrin modified magnetic gelatin
  • Cyclodextrin modified magnetic gelatin for efficient adsorption of moxidectin and preparation method of cyclodextrin modified magnetic gelatin
  • Cyclodextrin modified magnetic gelatin for efficient adsorption of moxidectin and preparation method of cyclodextrin modified magnetic gelatin

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Embodiment 1

[0036] Specific examples of the preparation method of the present invention are introduced below.

[0037] Example 1

[0038] Such as figure 1 Shown, the preparation method of the present embodiment is as follows:

[0039] 1. Preparation of magnetic gelatin materials

[0040] 2 g of gelatin was dissolved in 35 mL of pure water, and then ferric trichloride and ferric sulfate (2 g in total) were added in a mass ratio of 2 / 1. After the temperature of the solution was raised to 70°C, 5 mL of aqueous ammonia solution was added dropwise and mechanically stirred at this temperature for 5 hours. Finally, wash the magnetic gelatin material with ethanol, water and other solutions.

[0041] 2. Preparation of vinyl modified cyclodextrin

[0042] Dissolve 5 g of cyclodextrin in 50 mL of anhydrous dimethylformamide, then add 3 g of glycidyl methacrylate, raise the temperature of the solution to 80° C. and stir for 5 hours. Finally, after dissolving the reaction product with a large vo...

Embodiment 2

[0046] 1. Preparation of magnetic gelatin materials

[0047] Dissolve 3g of gelatin in 60mL of pure water, then add ferric chloride and ferric sulfate at a mass ratio of 2 / 1, the total amount is 6.0g. After raising the temperature of the solution to 65 °C, 6 mL of ammonia solution was added dropwise, and mechanically stirred at this temperature for 5 hours. Finally, wash the magnetic gelatin material with ethanol, water and other solutions.

[0048] 2. Preparation of vinyl modified cyclodextrin

[0049] Dissolve 6 g of cyclodextrin in 50 mL of anhydrous dimethylformamide, then add 1.0 g of glycidyl methacrylate, raise the temperature of the solution to 80° C. and stir for 5 hours. Finally, after dissolving the reaction product with a large volume of ethyl acetate, the solution was blown dry under the protection of nitrogen to obtain vinyl-modified cyclodextrin.

[0050] 3. Preparation of cyclodextrin-modified magnetic gelatin

[0051]Dissolve the magnetic gelatin in the aq...

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Abstract

The invention provides a cyclodextrin modified magnetic gelatin for efficient adsorption of moxidectin and a preparation method of the cyclodextrin modified magnetic gelatin. The method comprises the following steps: firstly, preparing a magnetic gelatin; secondly, preparing vinyl modified cyclodextrin; and finally, performing reaction between the magnetic gelatin and the vinyl modified cyclodextrin to obtain the cyclodextrin modified magnetic gelatin. The cyclodextrin modified magnetic gelatin is prepared for the first time by the method provided by the invention, the efficient adsorption of moxidectin can be realized, the magnetic separation property can realize quick recovery of materials, and the operation is simple. Used materials are low in toxicity, the preparation cost is low, the safety is high, and the after-treatment is simple. Therefore, the method provided by the invention is far superior to an existing preparation method either safety of preparation or easy operability of the preparation process.

Description

technical field [0001] The invention relates to the field of food safety, in particular to cyclodextrin-modified magnetic gelatin with high absorption of moxidectin and a preparation method thereof. Background technique [0002] Moxidectin is a new type of antiparasitic drug, which is a semi-synthetic macrolide drug with a single component produced by fermentation of Streptomyces. The drug has the characteristics of strong effect on pests, less dosage, safe for humans and animals, and not easy to produce resistance. It is currently the most promising broad-spectrum, high-efficiency, new type of non-cross-resistance biological insecticide. Although moxidectin has high safety, its half-life is long, which can easily cause moxidectin residues in food. The maximum residue limit of moxidectin in EU, US and Japan is 20μg / kg in beef / mutton, 100μg / kg in liver, 50μg / kg in kidney and 40μg / kg in milk . However, there is no national standard for the detection of moxidectin in my coun...

Claims

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Application Information

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IPC IPC(8): C08G81/00C08F251/00C08F220/06C08B37/16
Inventor 尚吟竹王鹏荆涛罗静赵晓亚
Owner 武汉鸿漫源检测技术科技有限公司
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