A kind of vaginal retention boric acid preparation and preparation method thereof

A boric acid, vaginal technology, applied in the field of medicine, can solve problems such as biofilm destruction

Active Publication Date: 2018-08-31
惠峪 +2
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this patent proves the destructive effect of boric acid on biofilm by in vitro experiments, it does not fundamentally change the clinical application of boric acid to the treatment of bacterial or fungal vaginitis

Method used

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  • A kind of vaginal retention boric acid preparation and preparation method thereof
  • A kind of vaginal retention boric acid preparation and preparation method thereof
  • A kind of vaginal retention boric acid preparation and preparation method thereof

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Embodiment Construction

[0034] 1. Definition and naming

[0035] Bioadhesion, as described herein, is the state in which two materials (at least one of which is an organism in nature) are held together by interfacial forces over a prolonged period of time. Bioadhesion means that the carrier system carrying the drug can bind to a specific biological surface, which can be the surface of epithelial tissue or mucosal tissue.

[0036] The bioadhesive polymeric materials described herein are polymeric materials that can act as adhesives, which can be synthetic glues formed from biological monomers, such as sugars, or other synthetic adhesives designed to attach to biological tissues. Material.

[0037] Bioadhesive polymer materials described herein include, but are not limited to, gum arabic acaciagum alginic acid alginic acid carbomer / carbopol polycarbophil polycarbophil hydroxypropyl methylcellulose sodium hyaluronate sodium hyaluronate pectin pectin polyvinyl alcohol polyvinyl pyrrolidone tragacanth t...

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Abstract

The invention discloses a vagina-retained boric acid preparation and a preparation method thereof. To be specific, optimally, the vagina-retained boric acid preparation is mainly prepared from methylparaben, propyl hydroxybenzoate, potassium sorbate, chitosan, glycerol, carbomer 974, polycarbophil, boric acid and purified water. The performance of the vagina-retained boric acid preparation is mainly characterized in that the preparation can be retained in vagina and release boric acid which serves as a bacteriostasis element, and it is proved through experiments that by the adoption of the gel, the high boric acid concentration in vagina liquid can be reached and maintained for a long time. The invention further discloses the preparation method of the vagina-retained boric acid preparation. Furthermore, it is proved through tests that the dynamic viscosity of the vagina-retained boric acid preparation is greater than 100000 centipoises, the pH value ranges from 2 to 5, the water retention property is good, no allergenicity exists, no vagina irritation exists, and the bacterium and fungus inhibition effect is achieved.

Description

technical field [0001] The invention relates to a vaginal retention boric acid antibacterial gel and a preparation method thereof, belonging to the field of medicine. Vaginal retention boric acid antibacterial gel is a new type of boric acid preparation, which is composed of bioadhesive polymer materials to form a skeleton structure, which can retain and release boric acid as an antibacterial component in vaginal fluid, and has antibacterial effect. It involves preparations science, analytical chemistry, and microbiology. Background technique [0002] About 80-95% of vaginitis is caused by Candida albicans infection. T. glabrata infection accounts for only 5%-15% of the etiology of vaginitis, and the treatment methods are very limited. Therefore, there are not many reports on the treatment of T.glabrata vaginitis in the literature. [0003] However, the incidence of T. glabrata is increasing, which may be due to short-term treatment with systemic oral conazoles and overus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K33/22A61K47/30A61P15/00A61P15/02A61P31/04A61P31/10A61P33/02
Inventor 惠峪袁旭东张田
Owner 惠峪
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