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Anti-calcification treatment method for biological materials

A technology of calcification treatment and biomaterials, which is applied in the field of biomedicine, can solve the problems of affecting the fatigue resistance and service life of biomaterials, affecting the performance and life expectancy, and poor anti-calcification performance, so as to achieve enhanced anti-calcification effect and treatment The method is simple and feasible, and the effect of avoiding the risk of secondary replacement

Active Publication Date: 2016-03-02
KINGSTRONBIOCHANGSHU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is also calcification of biomaterials after implantation into the human body, which directly affects their performance and life expectancy, leading to the risk of secondary surgical implantation. Therefore, the problem of calcification of biomaterials has always been a problem that plagues the biomedical community. How to effectively The anti-calcification of biomaterials has been the research direction of many scientific researchers
However, the above anti-calcification treatment methods have problems such as poor local anti-calcification performance, easy to cause damage and even delamination of biological materials, thus affecting the fatigue resistance and service life of biological materials.

Method used

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  • Anti-calcification treatment method for biological materials

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The microemulsion 1 of the present embodiment comprises the following components in parts by weight: 25 parts of ethanol, 10 parts of n-amyl alcohol, 3 parts of Tween-803 parts, 5.5 parts of fatty alcohol polyoxyethylene ether (AEO-9), 1.0 part of oleic acid, Amino silicone oil 0.5 parts, water 55 parts.

[0030] Microemulsion 1 was prepared from the above components according to the conventional preparation method of microemulsion at 25°C. The particle size analysis of the prepared microemulsion was carried out using a MalvernNano ZS90 particle size analyzer. The average particle size of the prepared microemulsion in this embodiment was 95.4 nm, and the particle size distribution was 0.586.

[0031] Completely immerse 1 piece of decellularized bovine pericardium (5cm × 5cm) in 200g microemulsion 1, manually stir once every 10min with a stirring rod, each stirring time is 1min, after 4 hours, stop stirring, and let it stand for 20 minutes Hour. The bovine pericardium ...

Embodiment 2

[0033] The microemulsion 2 of the present embodiment comprises the following components in parts by weight: 800.9 parts of Tween, 0.2 part of polyethylene glycol octylphenyl ether (TritonX-100), 8.4 parts of ethanol, 0.3 part of oleic acid, 0.2 part of squalane Parts, 90 parts of 0.9% normal saline.

[0034] At 25°C, the above components were prepared according to the conventional preparation method of microemulsion to prepare microemulsion 2. The particle size analysis of the prepared microemulsion 2 was carried out using a MalvernNanoZS90 particle size analyzer. The average particle size of the prepared microemulsion 2 in this embodiment was 31.84 nm, and the particle size distribution was 0.098.

[0035] One piece of decellularized bovine pericardium (5cm×5cm) was completely immersed in a container containing 300g of microemulsion 2, and the container was placed on a vibrating shaker, and the frequency was controlled to be 30-70rmp / min for oscillation. After 24 hours, the ...

Embodiment 3

[0037] The microemulsion 3 of the present embodiment comprises the following components in parts by weight: 201.7 parts of Tween, 1.6 parts of TritonX-100, 0.3 parts of potassium oleate, 17 parts of ethanol, 5.1 parts of isopropanol, 0.1 part of linoleic acid, and 74.2 parts of water .

[0038] At 35° C., the above components were prepared according to the conventional preparation method of microemulsion to prepare microemulsion 3 . The particle size analysis of the prepared microemulsion 3 was carried out using a MalvernNanoZS90 particle size analyzer. The average particle size of the prepared microemulsion 3 in this embodiment was 12.2 nm, and the particle size distribution was 0.091.

[0039] Completely immerse the 15cm bovine jugular vein valved pipeline without decellularization into a container containing 500g of microemulsion 3, put the container in an ultrasonic cleaner, set the ultrasonic frequency to 40KHZ, and ultrasonically once every 30min, each time Ultrasonic 5...

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Abstract

The invention provides an anti-calcification treatment method for biological materials; microemulsions are used for treating the biological materials. The microemulsions adopted by the invention can comprise fatty acid and derivatives thereof. The anti-calcification treatment method provided by the invention can improve the anti-calcification performance of the biological materials.

Description

technical field [0001] The invention relates to biomedical technology, in particular to an anti-calcification treatment method for biological materials. Background technique [0002] Biomaterials are a class of high-tech materials used to diagnose, repair or enhance the functions of human tissues and organs, that is, natural or artificial materials used to replace and repair human living tissues, and their functions cannot be replaced by drugs. However, there is also calcification of biomaterials after implantation into the human body, which directly affects their performance and life expectancy, leading to the risk of secondary surgical implantation. Therefore, the problem of calcification of biomaterials has always been a problem that plagues the biomedical community. How to effectively Anti-calcification of biomaterials has been the research direction of many scientific researchers. [0003] At present, the anti-calcification treatment method mainly used clinically is to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50
Inventor 钟生平刘静
Owner KINGSTRONBIOCHANGSHU CO LTD