Unlock instant, AI-driven research and patent intelligence for your innovation.

Anti-calcification treatment method of biological material

A biomaterial and calcification technology, applied in the field of biomedicine, can solve problems such as uselessness, and achieve the effect of improving the service life and enhancing the anti-calcification effect.

Inactive Publication Date: 2019-10-18
太仓新亚逊生物科技有限公司
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcification is normal and physiological in the formation of bone marrow, enamel and dentin, but calcium deposition in soft tissues is abnormal and useless

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0017] Embodiment: a kind of anti-calcification processing method of biological material, comprises the following steps:

[0018] S1, immersing the biological material in a crosslinking agent solution, the immersion temperature is 20-30°C, and the immersion time is 4-6d;

[0019] S2, immersing the biological material in a glutaraldehyde solution, the immersion temperature is 20-25°C, and the immersion time is 2-3d;

[0020] S3, immersing the biological material in the microemulsion, the immersion temperature is 20-25°C, and the immersion time is 72h.

[0021] The crosslinking agent solution is a mixed solution of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, and the 1-ethyl-3-(3 The mixing mass ratio of -dimethylaminopropyl)carbodiimide to the N-hydroxysuccinimide is 3:1.

[0022] The concentration of the glutaraldehyde solution is 0.3-0.6%, and the pH value is 6.0-7.0.

[0023] The microemulsion comprises sodium lauryl sulfate, potassium oleate, ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an anti-calcification treatment method of a biological material. The method includes the following steps of S1, soaking the biological material in a crosslinking agent solutionat the soaking temperature of 20-30 DEG C for the soaking time of 4-6 days; S2, soaking the biological material in a glutaraldehyde solution at the soaking temperature of 20-25 DEG C for the soakingtime for 2-3 days; S3, soaking the biological material in a micro-emulsion at the soaking temperature of 20-25 DEG C for the soaking time of 72 hours. In this way, on the premise of ensuring the structure and the mechanical performance of the biological material, the anti-calcification effect of the biological material is enhanced, and thus the service life of the biological material is prolonged.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to an anti-calcification treatment method for biological materials. Background technique [0002] Biological material refers to a material that can diagnose, treat, enhance or replace the tissue, organ or function of a living body after contacting with a biological system. Biomaterials have been widely used in various fields nowadays, but due to biocompatibility problems, there are a series of problems such as infection, tumor and pathological calcification when biomaterials are implanted into the human body. [0003] Calcification is the appearance of unwanted calcium phosphate deposits on the surface and in the interior of implanted materials. These lesions may affect the properties of heart valves, pacemakers, and soft lenses for urethral repair. Calcification is normal and physiological in the formation of bone marrow, enamel and dentin, but calcium deposits in soft tissues...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/36A61L27/20A61L27/22A61L27/24A61L27/50
CPCA61L27/3604A61L27/362A61L27/3625A61L27/3687A61L27/24A61L27/222A61L27/20A61L27/50A61L2400/02C08L5/08
Inventor 陈华成
Owner 太仓新亚逊生物科技有限公司