Anti-calcification treatment method of biological materials
A technology of calcification treatment and biomaterials, which is applied in the field of biomedicine, can solve the problems of affecting the fatigue resistance and service life of biomaterials, affecting the performance and life expectancy, and poor anti-calcification performance, so as to achieve enhanced anti-calcification effect and treatment The method is simple and feasible, and the effect of avoiding the risk of secondary replacement
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Embodiment 1
[0029] The microemulsion 1 of the present embodiment comprises the following components in parts by weight: 25 parts of ethanol, 10 parts of n-amyl alcohol, 3 parts of Tween-803 parts, 5.5 parts of fatty alcohol polyoxyethylene ether (AEO-9), 1.0 part of oleic acid, Amino silicone oil 0.5 parts, water 55 parts.
[0030] Microemulsion 1 was prepared from the above components according to the conventional preparation method of microemulsion at 25°C. The particle size analysis of the prepared microemulsion was carried out by MalvernNano ZS90 particle size analyzer. The average particle size of the prepared microemulsion in this embodiment was 95.4 nm, and the particle size distribution was 0.586.
[0031] Completely immerse 1 piece of decellularized bovine pericardium (5cm × 5cm) in 200g microemulsion 1, manually stir once every 10min with a stirring rod, each stirring time is 1min, after 4 hours, stop stirring, and let it stand for 20 minutes Hour. The bovine pericardium mater...
Embodiment 2
[0033] The microemulsion 2 of the present embodiment comprises the following components in parts by weight: 0.9 part of Tween 80, 0.2 part of polyethylene glycol octylphenyl ether (Triton X-100), 8.4 parts of ethanol, 0.3 part of oleic acid, squalene 0.2 parts of alkanes, 90 parts of 0.9% normal saline.
[0034] At 25°C, the above components were prepared according to the conventional preparation method of microemulsion to prepare microemulsion 2. The particle size analysis of the prepared microemulsion 2 was carried out using a MalvernNano ZS90 particle size analyzer. The average particle size of the prepared microemulsion 2 in this embodiment was 31.84 nm, and the particle size distribution was 0.098.
[0035] One piece of decellularized bovine pericardium (5cm×5cm) was completely immersed in a container containing 300g of microemulsion 2, and the container was placed on a vibrating shaker, and the frequency was controlled to be 30-70rmp / min for oscillation. After 24 hours,...
Embodiment 3
[0037] The microemulsion 3 of the present embodiment comprises the following components in parts by weight: 1.7 parts of Tween 20, 1.6 parts of Triton X-100, 0.3 parts of potassium oleate, 17 parts of ethanol, 5.1 parts of isopropanol, 0.1 part of linoleic acid, water 74.2 servings.
[0038] At 35° C., the above components were prepared according to the conventional preparation method of microemulsion to prepare microemulsion 3 . The particle size analysis of the prepared microemulsion 3 was carried out using a MalvernNano ZS90 particle size analyzer. The average particle size of the prepared microemulsion 3 in this embodiment was 12.2 nm, and the particle size distribution was 0.091.
[0039] Completely immerse the 15cm bovine jugular vein valved pipeline without decellularization into a container containing 500g of microemulsion 3, put the container in an ultrasonic cleaner, set the ultrasonic frequency to 40KHZ, and ultrasonically once every 30min, each time Ultrasonic 5mi...
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