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Biomarkers predicting prophylactic efficacy of lithium in bipolar affective disorders

A lithium salt, curative effect technology, applied in the field of personalized drug therapy, can solve problems such as no curative effect

Inactive Publication Date: 2018-08-31
ACAD SINICA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are many patients who do not respond to lithium therapy

Method used

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  • Biomarkers predicting prophylactic efficacy of lithium in bipolar affective disorders
  • Biomarkers predicting prophylactic efficacy of lithium in bipolar affective disorders
  • Biomarkers predicting prophylactic efficacy of lithium in bipolar affective disorders

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Embodiment Construction

[0009] The finding of an association between glutamate decarboxylase-like 1 (GADL1) variants and lithium efficacy in patients with bipolar disorder was unexpected. Patients with one or more variants of the GADL1 gene were more likely to respond to lithium therapy.

[0010] GADL1 belongs to the second group of the decarboxylase (decarboxylase) family, such as the location of the genome (chromosome No. 3), genomic DNA sequence (see, for example, NC_000003.11Reference GRCh37.p13PrimaryAssembly, chr3:30767692-30936153), cDNA sequence (see Accession No. NM_207359.2) and human GADL1 protein sequence (see eg Accession No. NP_997242.2).

[0011] The amino acid sequence of an exemplary GADL1 polypeptide and the cDNA sequence encoding the polypeptide are shown below.

[0012] Human GADL1 amino acid sequence (SEQ ID NO: 1):

[0013] MSSDSDRQCPVDGDIDQQEMIPSKKNAVLVDGVVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKQLLDLEMRDSGEPPHKLLELCRDVIHYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLV...

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Abstract

Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 1VS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.

Description

technical field [0001] The present invention relates to a kind of personalized medicine treatment utilizing single nucleotide polymorphism (Single Nucleotide Polymorphism, SNP). Background technique [0002] Bipolar disorder (Biopolar disorder) is characterized by recurrent abnormal emotional states of two extremes of agitation and depression, see, for example: Müller-Oerlinghausen et al., Lancet 2002; 359:241-7; and Frye MA., N Engl J Med 2011;364:51-9. Recently, lithium salt (lithium) is the first-line drug for long-term treatment of bipolar disorder, which can effectively reduce the risk of relapse and suicide in patients, see for example: Fountoulakis et al., Eur Arch Psychiatry Clin Neurosci 2012; 262Suppl1:1- 48. However, there are many patients who do not respond to lithium therapy. Contents of the invention [0003] The present invention provides a method for detecting the curative effect of lithium salts (lithium) on patients with bipolar disorder, the method c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883A61K33/00C12Q2600/106C12Q2600/156C12Q2600/172
Inventor 陈垣崇郑泰安陈建勋李朝雄李明达
Owner ACAD SINICA
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