Application of Kanshone C to preparing drug for resisting human body fungi

A technology against human fungi and drugs, applied in the direction of antifungal agents, etc., can solve the problems of strong accumulation of toxicity, irritation of the digestive tract, etc., and achieve the effect of strong inhibitory activity against human fungi and highlighting substantive characteristics

Inactive Publication Date: 2016-03-23
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots

Method used

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  • Application of Kanshone C to preparing drug for resisting human body fungi
  • Application of Kanshone C to preparing drug for resisting human body fungi
  • Application of Kanshone C to preparing drug for resisting human body fungi

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of the compound KanshoneC tablet involved in the present invention:

[0012] Take 20 grams of compound KanshoneC, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0013] Embodiment 2: the preparation of the compound KanshoneC capsules involved in the present invention:

[0014] Take 20 grams of compound KanshoneC, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 3

[0016] Experimental example 3: KanshoneC anti-fungal activity in humans

[0017] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of KanshoneC is 50.0μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098μg / mL, the same volume of bacteria liquid and test samples are mixed and cultured in a 96-well plate, and the human fungus culture temperature is respectively 28°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of KanshoneC against human fungi are shown in Table 1.

[0018] Table 1 KanshoneC anti-human fungal MIC value (μg...

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Abstract

The invention relates to application of Kanshone C to preparing drug for resisting human body fungi and belongs to the medicine field. Kanshone C has a high inhibition effect on red trichophyton, microsporum lanosum or fungi imperficti, and therefore Kanshone C can serve as compounds resisting human body fungi, and it is hopeful that Kanshone C is applied to preparing relevant drugs. The application of Kanshone C to preparing drug for resisting human body fungi is disclosed for the first time, due to the fact that the skeleton type is a brand-new skeleton type, Kanshone C has unexpected inhibition activity on human body fungi, it is not possible that other compounds provide any revelation, Kanshone C has outstanding substantive features, and remarkable progress is made in human body fungus infection prevention and treatment.

Description

technical field [0001] The present invention relates to a new application of compound KanshoneC, in particular to the application of KanshoneC in the preparation of antifungal drugs for human body. Background technique [0002] The spread of pathogenic bacteria and the enhancement of drug resistance seriously threaten human health and life. Antibacterial drugs have been widely used as routine drugs in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) Treatment, although antibacterial agents currently used clinically (such as ketoconazole, amikacin, gentamicin, vigorconazole, itraconazole, terbinafine, amphotericin, fluconazole, etc.) The curative effect on skin and superficial infection is good, but these antibacterial drugs have strong accumulation toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc. one of the hotspots. [0003] The compound KanshoneC invo...

Claims

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Application Information

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IPC IPC(8): A61K31/336A61P31/10
CPCA61K31/336
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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