Single/multi-component droplet preparation device and control method based on integrated microchannel

A technology for preparing devices and microchannels, applied in fluid controllers, measuring tubes/pipettes, chemical instruments and methods, etc., can solve the problems of long production cycle, unfavorable industrial production, high cost, and achieve a small number of pumps, Simple structure and operation, good monodispersity effect

Active Publication Date: 2018-03-16
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production cycle and high cost of the microchannel equipment required to manufacture stepped emulsification by photolithography and other processing methods are not conducive to actual industrial production

Method used

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  • Single/multi-component droplet preparation device and control method based on integrated microchannel
  • Single/multi-component droplet preparation device and control method based on integrated microchannel
  • Single/multi-component droplet preparation device and control method based on integrated microchannel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of one-component aqueous phase droplets

[0048] (1) Select the continuous phase as silicone oil and the discrete phase as deionized water. 5% mass fraction of surfactant (Dow Corning 749) was added to the silicone oil, and it was placed in a continuous phase container. A small amount of rhodamine b was added to deionized water and loaded into a syringe.

[0049] (2) A preparation device for producing single-component droplets according to the above method. The distance between the two splints of the discrete phase outlet joint is h=0.3 mm, and the distance between the microchannel outlet and the lower side of the discrete phase outlet joint is 1.3 mm. In this example, two channels (the third channel and the sixth channel) are used to prepare droplets at the same time. In this example, the flow rate of deionized water is set to 5 mL / h as required. Turn on the syringe pump and adjust to the stated flow.

[0050] (3) After the deionized water rea...

Embodiment 2

[0051] Example 2 Determination of critical flow rate of mechanism transition during single-channel droplet preparation

[0052] (1) The continuous phase is silicone oil plus 5% Dow Corning 749, and the discrete phase is deionized water plus a small amount of rhodamine b. The viscosity of water is 1.005 mPa·s, the surface tension between the silicone oil and water is about 2 mN / m, and the inner diameter of the channel is 500 microns.

[0053] (2) A preparation device for producing single-component droplets according to the above method. The distance between the two splints of the discrete phase outlet joint is h=0.3 mm, and the distance between the microchannel outlet and the lower side of the discrete phase outlet joint is 1.3 mm.

[0054] (3) In this example, a single channel is used to prepare droplets, and the flow rate is between 2mL / hr and 66mL / hr to take a value every 4mL / hr. The obtained droplet size is as follows Figure 8 shown. It can be seen that when the flow ra...

Embodiment 3

[0055] Example 3 Preparation of two-component aqueous phase droplets

[0056] (1) Select the continuous phase as silicone oil, add 5% mass fraction of surfactant (Dow Corning 749) to the silicone oil, and put it in a continuous phase container. The first discrete phase was chosen to be deionized water with a small amount of rhodamine b added and loaded into a syringe. The second discrete phase was chosen to be deionized water with a small amount of Nile blue added and loaded into another syringe.

[0057] (2) A preparation device for making two-component droplets according to the above method. The distance between the two splints of the discrete phase outlet joint is h=0.3 mm, and the distance between the microchannel outlet and the lower side of the discrete phase outlet joint is 1.3 mm. In this example, two channels are used to prepare two-component droplets, and the two channels are respectively connected with deionized water containing rhodamine b and deionized water con...

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Abstract

The invention discloses a single / multiple-component droplet preparation device based on integrated micro-channels and a control method of the single / multiple-component droplet preparation device. The device comprises a micro-channel plastic film, a dispersed phase inlet joint, a dispersed phase outlet joint, a continuous phase container, an injection pump and the like, wherein one end of the micro-channel plastic film is connected with the dispersed phase inlet joint, the other end is connected with the dispersed phase outlet joint, the dispersed phase inlet joint is connected with the injection pump, and the dispersed phase outlet joint is immersed in the container filled with a continuous phase. A dispersed phase is pushed by the injection pump to flow and the flow is controlled, so that dispersed phase droplets can be generated in the continuous phase container. Monodispersed droplets can be generated rapidly with a large flux, multiple-component droplets can be prepared, and the device is expected to be applied to the fields of drug preparation, chemical synthesis, biomedicine and the like.

Description

technical field [0001] The invention relates to the field of microfluidics and the technical fields of chemical engineering and biopharmaceuticals, in particular to a single / multi-component droplet preparation device based on integrated microchannels and a control method thereof. Background technique [0002] Droplets have been widely used in the fields of drug particle preparation, medical detection and analysis, and fine chemicals. At present, the methods for preparing droplets mainly include microfluidic control preparation method, spray method and capillary droplet control method. Among them, the microfluidic method utilizes some special fluid flow mechanisms in the microchannel structure to prepare droplets, and the resulting droplets have high size uniformity and strong controllability, and have significant advantages compared with other methods. [0003] The methods of using microfluidic control to prepare droplets mainly include T-channel method, fluid focusing meth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/02
CPCB01L3/0251B01L3/0268B01L2200/027B01L2200/061B01L2300/0838B01L2300/0864B01L2400/0406B01L2400/088
Inventor 许忠斌陈东黄兴崔赟
Owner ZHEJIANG UNIV
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