Double-control drug delivery carrier based on inorganic nano silicon material and preparation method of double-control drug delivery carrier

A technology of inorganic nano-silicon and transmission carrier, which is applied in the field of nano-medicine technology and drug controlled release, achieving the effects of good stability, large drug loading capacity and broad application prospects

Active Publication Date: 2016-04-20
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is no report on a dual-controlled drug delivery carrier b

Method used

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  • Double-control drug delivery carrier based on inorganic nano silicon material and preparation method of double-control drug delivery carrier
  • Double-control drug delivery carrier based on inorganic nano silicon material and preparation method of double-control drug delivery carrier
  • Double-control drug delivery carrier based on inorganic nano silicon material and preparation method of double-control drug delivery carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 (the synthesis of MSNs):

[0038]

[0039] 250mg CTAB mixed with 120mLH 2 O, take 875 μL of 2M NaOH solution with a pipette, stir the mixture, and raise the temperature to 80 °C. After the temperature stabilized, 1.5 mL TOES was added dropwise. Stir vigorously at 80 °C for 2 h. The synthesized nanomaterials were centrifuged and washed three times with ethanol. Dry in vacuum at 50°C for 8h. The scanning electron microscope image of the synthesized MSNs is shown in figure 1 shown.

Embodiment 2

[0040] Embodiment 2 (synthesis of ethylenediamine cyclodextrin):

[0041]

[0042] ①Put 30mg of refined β-cyclodextrin and 150mL of water into a 250mL three-neck flask, add 10mL of 8.25M NaOH solution, and continue stirring for 1 hour after the solution is clear. Add p-toluenesulfonyl chloride in acetonitrile solution (7.5g p-toluenesulfonyl chloride: 15mL acetonitrile), and stir at room temperature for 2h.

[0043] ②Filtrate, adjust the pH to 8.0-9.0, put it in a refrigerator at 4°C overnight, a large amount of white solid precipitates, filter it with suction, and recrystallize it with water three times. Dry in vacuum at 50°C for 6h.

[0044] ③Weigh 2.0g of the above solid in a round bottom flask, add 30mL of ethylenediamine, and stir at 80°C for 6h. Unreacted ethylenediamine was distilled off under reduced pressure, cooled to room temperature, and recrystallized with ethanol-water. A white solid precipitated, which was recrystallized twice.

Embodiment 3

[0045] Embodiment 3 (the synthesis of 4-(N-propyltriethoxysilane) urea azobenzene):

[0046] 0.79 g of 4-aminoazobenzene was dissolved in 10 mL of THF (anhydrous), and placed in a 25 mL single-necked bottle. Add 0.68 g of propyltriethoxysilane isocyanate, mix and reflux overnight under nitrogen protection. The solvent was spin-dried, and the residue was recrystallized twice from n-hexane / THF. Needle crystals are precipitated at 0°C. Filter and wash with n-hexane three times. Vacuum dry.

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PUM

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Abstract

The invention relates to the technical field of nano-drugs and the field of drug controlled release, in particular to a pH and ultraviolet light double-control drug delivery carrier based on an inorganic nano silicon material and a preparation method of the double-control drug delivery carrier. Through modification of the periphery of porous channels of the inorganic nano silicon material, a pH control part and an ultraviolet light control part are grafted and are linked to the same cyclodextrin through chemical bonds and hydrophobic interaction. Through double switch control, the release of a drug can be more accurately controlled; given the advantages of high drug loading capacity, good stability, easiness in modification and the like of the inorganic nano silicon material, the physiological pH of the cancer tissue and the physiological pH of the inflammatory site are both lower than that of normal tissue. The double-control drug delivery carrier has wide application prospect in the aspect of preparation of preparations for accurately controlling drug release, in particular to cancer and inflammation treatment.

Description

technical field [0001] The invention relates to the technical field of nano-medicine and the field of drug controlled release, in particular to a dual-controlled drug delivery carrier based on inorganic mesoporous nano-silicon material and a preparation method thereof. Background technique [0002] Due to its outstanding thermal and chemical stability, low cytotoxicity and biotoxicity, adjustable pore size and shape, easy surface and pore modification, and its excellent drug loading, mesoporous nano-silicon materials make it It has become a promising drug carrier. Therefore, mesoporous nano-silicon materials have become the hot spot and frontier of international research in the field of drug release. [0003] In order to better reduce the toxic and side effects of drugs, improve the utilization rate of drugs, and effectively control drug release, in recent years, the research and application of controllable drug release carriers have attracted extensive attention and strong...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/40A61K49/00C08B37/16
CPCA61K47/02A61K47/40A61K49/0052A61K49/0054A61K49/0093C08B37/0012
Inventor 程探宇赵军伟刘国华王紫云
Owner SHANGHAI NORMAL UNIVERSITY
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