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Method and device for monitoring calcium ion concentration in deep layers using the principle of photoacoustic-fluorescence complementarity

A technology for concentration monitoring and calcium ions, which is applied in measuring devices, fluorescence/phosphorescence, and material analysis through optical means, can solve the problems of not being able to monitor changes in calcium ion concentration in deep layers, and achieve the effect of simple operation

Inactive Publication Date: 2019-06-28
SOUTH CHINA NORMAL UNIVERSITY
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Problems solved by technology

However, due to the influence of biological tissues on fluorescence scattering, fluorescence imaging methods cannot monitor changes in calcium ion concentrations in deep layers.

Method used

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  • Method and device for monitoring calcium ion concentration in deep layers using the principle of photoacoustic-fluorescence complementarity
  • Method and device for monitoring calcium ion concentration in deep layers using the principle of photoacoustic-fluorescence complementarity

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Embodiment 1

[0044] Schematic diagram of the structure of the deep calcium ion concentration monitoring device using the principle of photoacoustic-fluorescence complementarity figure 1 shown.

[0045]The monitoring device includes: 1 is a computer with acquisition control software, image reconstruction software and motor control software; 2 is a three-dimensional scanning platform; 3 is a photoacoustic fluorescence signal excitation source; 4 is a mirror; 5 is a sample stage for placing samples ; 6 is an ultrasonic coupling cup; 7 is a bowl-shaped hollow focused ultrasonic detector; 8 is a microscope objective lens; 9 is a beam splitter; 10 is a filter; 11 is a photomultiplier tube; 12 is a signal amplifier; 13 is a beam expander lens Group.

[0046] Wherein, the photoacoustic fluorescence excitation light source 3, the signal amplifier 12, the photomultiplier tube 11, and the three-dimensional scanning platform 2 are electrically connected to the computer 1 with acquisition control soft...

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Abstract

The invention discloses a deep calcium ion concentration monitoring method using a photoacoustic-fluorescent complementary principle and a device using the same. The method can detect calcium ion concentration change through detection of change of intensity of a photoacoustic signal of a calcium ion fluorescent probe. The device comprises a photoacoustic-fluorescent signal excitation source, a bowl-shaped hollow focusing ultrasonic detector, a photomultiplier, a reflector, a light splitter, an expanded beam lens group, a microobjective, an ultrasonic coupling beaker, a sample bench, a 3D scanning platform, an optical filter, a signal amplifier, a two-channel parallel acquisition card and a computer with image reconstruction software, acquisition control software and motor control software. The method and device realize deep tissue calcium ion concentration monitoring, are convenient for operation, has calcium ion fluorescent probe sensitivity of 0.15 micromoles per liter and realizes monitoring of change of a deep tissue calcium ion concentration. The method and device can realize detection of change of a deep tissue calcium ion concentration in real time and through the rate of the change, a pathological change of tissues can be deduced.

Description

technical field [0001] The invention belongs to the technical field of non-destructive testing and measurement, and in particular relates to a method and device for monitoring calcium ion concentration in deep layers using the photoacoustic-fluorescence complementary principle. Background technique [0002] At present, the change of calcium ion concentration is mainly monitored by observing the fluorescent signal of the calcium ion fluorescent probe. However, due to the influence of biological tissue on fluorescence scattering, fluorescence imaging methods cannot monitor changes in calcium ion concentration in deep layers. However, photoacoustic signals (photo-induced ultrasound) are much less affected by tissue scattering than photons, so we combine the non-destructive photoacoustic imaging technology with the high sensitivity of pure optical imaging and the deep penetration characteristics of pure ultrasonic imaging. It overcomes the limitation of light scattering and rea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64G01N21/17
CPCG01N21/1702G01N21/6428G01N21/6456G01N2021/1706
Inventor 邢达覃欢杨思华
Owner SOUTH CHINA NORMAL UNIVERSITY
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