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Preparation method of a highly sensitive nano-zirconia-doped bevanolol molecularly imprinted electrochemical sensor

A technology of nano-zirconia and molecular imprinting, applied in the direction of material electrochemical variables, etc., can solve the problems of functional monomers, cross-linking agents and template molecules that cannot be properly matched, low sensitivity, poor cross-linking rigidity, etc., and achieve excellent Sensitivity, simple equipment, and easy-to-make effects

Inactive Publication Date: 2017-11-24
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The current method is not sensitive because the selected functional monomers, cross-linking agents and template molecules cannot be properly matched, and the rigidity of the cross-linking is also poor.

Method used

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  • Preparation method of a highly sensitive nano-zirconia-doped bevanolol molecularly imprinted electrochemical sensor

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1. Treatment of glassy carbon electrodes

[0015] Polish the glassy carbon electrode on a polishing cloth with 1.0 μm, 0.3 μm and 0.05 μm alumina powder in turn, then put it into nitric acid with a volume ratio of 1:1 for 8 minutes, then put it into absolute ethanol for 8 minutes, and finally Ultrasonic cleaning with pure water.

[0016] 2. Preparation of Molecularly Imprinted Electrochemical Sensor for Bevanolol

[0017] To 10.0mL solvent ethanol, sequentially add 0.5mmol template molecule bevanolol, 3.0mmol functional monomer (5s, 8s)-3-(4'-chloro-3'-fluoro-4-propenyl Benzene-3-yl)-4-hydroxyl-8-ethoxy-1-azaspiro[4.5]dec-3-en-2-one, 3.5mmol crosslinking agent 3-(2-chloro-2-( 4-chlorophenyl) vinyl)-2,2-dimethylcyclopropanecarboxylic acid-α-cyano-(4-fluoro-3-phenoxyphenyl)-methyl ester, 0.1mmol initiator couple Azodiisobutyronitrile and 0.0250g of nano-zirconia, each added with a chemical reagent ultrasonically dissolved for 6 minutes;

[0018] Take 8 μL of the mix...

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Abstract

The present invention discloses a method for preparing a high-sensitivity nano-zirconia-doped bevantolol molecular imprinting electrochemical sensor, the high-sensitivity nano-zirconia-doped bevantolol molecular imprinting electrochemical sensor is prepared by use of bevantolol as a template molecule, (5s, 8s)-3-(4'-chloro-3'-fluoro-4-propenyl-biphenyl-3-yl)-4-hydroxy-8-ethoxy-1-aza-spiro [4.5] dec-3-ene-2-one as a single function monomer, azobisisobutyronitrile as an initiator, nano-zirconia as a dopant and 3-(2-chloro-2-(4-chlorophenyl) vinyl)-2,2-dimethyl-cyclopropane carboxylic acid-alpha-cyano-(4-fluoro-3-phenoxyphenyl)-methyl ester as a crosslinking agent, and the method is simple and practical, and overcomes the shortcomings that a conventional analysis method is complicated, expensive in equipment, and low in sensitivity.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a high-sensitivity nanometer zirconia-doped bevanalol molecularly imprinted electrochemical sensor. Background technique [0002] Bevanolol is a long-acting β-adrenoceptor blocker that acts on β 1 - Adrenal receptors are highly selective, have no intrinsic sympathomimetic activity, only weak local anesthetic effect, and are used for the treatment of arrhythmia, angina pectoris and mild to moderate hypertension. However, because long-term or excessive use of such drugs can cause drug addiction problems or side effects such as insomnia and nausea, and even cause fatal risks when the drug is suddenly stopped, it is listed as a controlled drug by most countries in the world. [0003] Methods for the determination of bevanolol include ultraviolet spectroscopy and high performance liquid chromatography. However, these methods have the disadvant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/48
CPCG01N27/30G01N27/48
Inventor 谭学才李浩雷福厚韦贻春陈其锋余会成
Owner GUANGXI UNIV FOR NATITIES