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A group of diagnostic markers for latent tuberculosis infection and its application

A technology for diagnostic markers and latent tuberculosis, applied in the field of latent tuberculosis infection diagnostic markers, can solve problems such as failure to consult the latent infection biomarkers of Mycobacterium tuberculosis

Inactive Publication Date: 2017-07-28
AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among the antigens found, except for the secreted proteins ESAT-6 and CFP-10 proteins, which have been used in the T-SPOT-TB assay to diagnose latent infection of tuberculosis, no organisms related to latent infection of Mycobacterium tuberculosis have been found so far. Reports about the logo

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  • A group of diagnostic markers for latent tuberculosis infection and its application
  • A group of diagnostic markers for latent tuberculosis infection and its application
  • A group of diagnostic markers for latent tuberculosis infection and its application

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Embodiment Construction

[0012] The technical solution of the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0013] 1. Discovery and validation of serum diagnostic markers

[0014] (1) Discovery and screening of tuberculosis diagnostic markers based on MtbProtTM protein chip:

[0015] 1. Detection principle: Purchase the MtbProtTM Mycobacterium tuberculosis proteome chip from Bo Chong Biological Company, which contains 4262 Mycobacterium tuberculosis recombinant proteins, covering >95% of the coding genes. Clinical serum samples include normal control group, tuberculosis latent infection group, and active tuberculosis group, which are independently reacted with the chip to detect the universal and specific anti-tuberculosis activity against one or several antigenic proteins in the experimental group. Antibodies (IgG or IgM), these antigenic proteins can be used as diagnostic markers to characterize disease states. ...

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Abstract

The invention discloses a group of latent tuberculosis infection diagnosis markers and application thereof. The sequences of the latent tuberculosis infection diagnosis markers correspond to SEQ:ID:NO:1-SEQ:ID:NO:8. According to the novel biomarkers for technologically detecting mycobacterium tuberculosis latent infection, latent infected person can be found as soon as possible, management on the latent tuberculosis infected person is enhanced, and the purpose of controlling tuberculosis prevalence and propagation is finally achieved.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and relates to a group of diagnostic markers for tuberculosis latent infection and uses thereof. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis and is listed as one of the major infectious diseases in my country. At present, the population base of Mycobacterium tuberculosis infection is large and the incidence rate is high. So far, there is no effective rapid serological diagnosis method, which has brought severe challenges to the prevention and control of tuberculosis. Therefore, when the control of tuberculosis is facing severe challenges today, it is extremely urgent to screen candidates for new biomarkers of tuberculosis and seek a new diagnostic technique, new drug and new vaccine. [0003] Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that seriously endangers human health. Humans are gener...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/569
CPCG01N33/5695G01N2469/10
Inventor 张建勇陈玲王霄彭章丽兰远波黄璐王建华张泓
Owner AFFILIATED HOSPITAL OF ZUNYI MEDICAL COLLEGE