A method of extracting curcumin from turmeric

A technology of curcumin and turmeric, which is applied in the extraction of effective components of traditional Chinese medicine, and in the field of extracting curcumin from turmeric, can solve the problems of waste and solvent consumption, achieve the effect of convenient operation, simple equipment, and improve the level of deep processing and utilization

Active Publication Date: 2018-05-11
BEIJING UNION UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thin-layer chromatography has a good separation effect, but it is only suitable for a small amount of samples; column chromatography has a large separation amount, but due to the low solubility of curcumin in the eluent, a large amount of solvent is often consumed, resulting in waste

Method used

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  • A method of extracting curcumin from turmeric
  • A method of extracting curcumin from turmeric
  • A method of extracting curcumin from turmeric

Examples

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Embodiment 1

[0056] Solution preparation:

[0057] Preparation of 70-85% acetone: Accurately measure 700-850mL of acetone, add distilled water to make up to 1000mL, and prepare 3000mL for later use.

[0058] Preparation of acetonitrile-5% acetic acid (1:1): Accurately measure 500mL of acetonitrile and 500mL of 5% acetic acid, mix well, filter through a magnetic funnel, and store in airtight for later use.

[0059] Preparation of 5% acetic acid aqueous solution: Accurately measure 50mL of acetic acid, dilute to 1000mL with double distilled water, mix well, filter through a magnetic funnel, and store in a sealed seal. Prepare 4000mL for later use.

[0060] 1. Crude extraction of curcumin:

[0061] Accurately weigh 70.00 g of turmeric powder, 700 mL of 75% acetone, and sonicate for 15 min / time with an interval of 20 min each time. Extracted 3 times, acetone was recovered under reduced pressure, and liquid-liquid extraction was carried out to obtain a tan oily extract, which was curcumin cr...

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Abstract

The invention provides a method for extracting curcumin from turmeric. The method comprises the following steps: weighing a certain amount of turmeric powder, adding 70-85% acetone according to the liquid-solid ratio of 1: 8-10, extracting for three times, decompressing and recovering acetone to obtain a dark brown oily extract, carrying out liquid-liquid extraction by the use of petroleum ether, water and ethyl acetate, carrying out crude separation, crystallizing and recrystallizing by the use of ethanol-water to obtain needle curcumin crystal, and measuring mass fraction by HPLC. Through calculation, purity detected by HPLC after crystallization can reach 88% and above, and purity detected by HPLC after recrystallization can reach 95% and above.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a method for extracting effective components of traditional Chinese medicines, in particular to a method for extracting curcumin from turmeric. Background technique [0002] Turmeric is the dry rhizome of Curcumalonga L., a plant in the ginger family, which has the functions of promoting qi and relieving pain, promoting menstrual flow and breaking blood, dispelling wind and treating numbness. In recent years, pharmacological studies at home and abroad have found that turmeric has various functions such as preventing and treating cancer and protecting brain nerves, so it has attracted much attention [1] . [0003] Curcumin, commonly known as curcumin, is mainly derived from the rhizome of the genus Curcuma longa in the ginger family [2] . A large number of studies have proved that curcumin has various pharmacological effects such as anti-oxidation, anti-inflammation, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/78C07C49/255
CPCC07C45/78C07C49/255
Inventor 黄汉昌
Owner BEIJING UNION UNIVERSITY
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