Composition for protecting cornea and its preparation method and application

Abstract

The invention discloses cornea protecting composition as well as a preparation method and an application thereof. Main components of the composition comprise a solid moisturizing and lubricating component, a liquid moisturizing and lubricating component, an osmoregulation component and water. The composition adopts double moisturizing and lubricating components including the solid moisturizing and lubricating component and the liquid moisturizing and lubricating component, so that the composition can be better spread and remained on the corneal surface and better protect the corneal epithelial layer, and damage caused by dryness to the cornea can be avoided. For a preparation process of the composition, a solution is not required to be heated to boiling, preparation operation is simpler, a preparation cycle is shorter than 48 h, cold storage is not needed during transportation and storage, and the transportation cost and use cost are reduced.

Description

Technical field [0001] The invention relates to the technical field of medical supplies for ophthalmic surgery, in particular to a composition for protecting the cornea, and a preparation method and application thereof. Background technique [0002] During eye examinations and eye surgery, the cornea is exposed to the outside world, loses the protection of tears, and suffers damage due to dryness. At present, most clinical solutions are frequent use of normal saline or commercially available viscoelastics on the corneal surface during examinations and operations. However, due to the short retention time of normal saline on the corneal surface, frequent use is required, which makes the operation intermittent and brings inconvenience to clinicians. In addition, excessive use of normal saline can cause swelling of the eyes of the patient and cause discomfort to the patient. The viscoelastic agent is relatively viscous and has poor dispersion on the surface of the cornea and cannot ...

AI Technical Summary

Problems solved by technology

Among them, the raw material cost of sodium hyaluronate and chitosan is high; and the product is unstable at high temperature, and transportation and storage need to be refrigerated; the means of reducing the number of particles, the number of colonies and the content of endotoxin cannot be used on these substances, making them The cleanliness is not easy to meet the requirements for surgical use

[0006] Although the prior art discloses a variety of eye products containing moisturizing and lubricating ingredients, there is still no product that can simultaneously meet the following conditions: good moisturizing and lubricating performance, good dispersion on the corneal surface, stable component properties, and bacterial colonization. Number, particle number, and endotoxin content are all easy to meet the requirements for surgical use

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