A method for preparing biomimetic microcapsules from phospholipid bilayer confined organic titanium source and natural pigment

A technology of natural pigments and organic titanium, which is applied in the preparation of microspheres, photosensitive equipment, titanium dioxide, etc., can solve the problems of complicated operation process and lack of functionality, and achieves simple preparation method, strong operability, and cheap and easy-to-obtain raw materials. Effect

Active Publication Date: 2018-12-04
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation of the above liposome / titanium dioxide composite materials, at least two steps are required. The operation process is complicated and the prepared materials are only used to improve the stability of liposomes and have no functionality.

Method used

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  • A method for preparing biomimetic microcapsules from phospholipid bilayer confined organic titanium source and natural pigment
  • A method for preparing biomimetic microcapsules from phospholipid bilayer confined organic titanium source and natural pigment
  • A method for preparing biomimetic microcapsules from phospholipid bilayer confined organic titanium source and natural pigment

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Add 25mg of cholesterol, 100mg of phospholipids, 0.05mg of tetrabutyl titanate, 0.1mg of natural pigments, and 10mL of chloroform into the flask, and mix them uniformly with ultrasound at room temperature, and remove the chloroform by rotary evaporation at 25°C to obtain a uniform green film. Then add 5 mL of 0.01 mol / L phosphate buffer solution with a pH value of 7 in the flask, use an ultrasonic cleaner to ultrasonically disperse at room temperature for 60 minutes at a frequency of 100 Hz and a power of 100 W, then stir and react at room temperature for 12 hours, and then the reaction product Centrifuge at a speed of 5000 rpm to obtain a green precipitate, wash the green precipitate with a 0.01mol / L phosphate buffer solution with a pH value of 7 until the supernatant is colorless, and then dry it naturally to obtain a green powder, which has photoelectric conversion Functional titanium dioxide biomimetic microcapsules. Depend on figure 1 and 2 It can be seen that th...

Embodiment 2

[0024] Add 25mg of cholesterol, 100mg of phospholipids, 0.1mg of tetrabutyl titanate, 0.1mg of natural pigments, and 10mL of chloroform into the flask, and mix them uniformly with ultrasound at room temperature, and remove the chloroform by rotary evaporation at 25°C to obtain a uniform green film. Then add 5 mL of 0.01 mol / L phosphate buffer solution with a pH value of 7 in the flask, use an ultrasonic cleaner to ultrasonically disperse at room temperature for 60 minutes at a frequency of 100 Hz and a power of 100 W, then stir and react at room temperature for 12 hours, and then the reaction product is Centrifuge at a speed of 5000 rpm to obtain a green precipitate, wash the green precipitate with 0.01mol / L phosphate buffer solution with a pH value of 7 until the supernatant is colorless, then dry it naturally to obtain a green powder, which has the function of photoelectric conversion TiO2 biomimetic microcapsules. Depend on image 3 and 4 It can be seen that the obtained ...

Embodiment 3

[0026] Add 25mg of cholesterol, 100mg of phospholipids, 0.15mg of tetrabutyl titanate, 0.1mg of natural pigment, and 10mL of chloroform into the flask, mix them uniformly by ultrasonic at room temperature, remove the chloroform by rotary evaporation at 25°C, and obtain a uniform green film. Then add 5 mL of 0.01 mol / L phosphate buffer solution with a pH value of 7 in the flask, use an ultrasonic cleaner to ultrasonically disperse at room temperature for 60 minutes at a frequency of 100 Hz and a power of 100 W, then stir and react at room temperature for 12 hours, and then the reaction product Centrifuge at a speed of 5000 rpm to obtain a green precipitate, wash the green precipitate with a 0.01mol / L phosphate buffer solution with a pH value of 7 until the supernatant is colorless, then dry it naturally to obtain a green powder, which has photoelectric Titanium dioxide biomimetic microcapsules with transforming functions. Depend on Figure 5 and 6 It can be seen that the tita...

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Abstract

The invention discloses a method for preparing biomimetic microcapsules from a phospholipid bilayer confined organic titanium source and natural pigments. In the method, liposomes are prepared by using phospholipids and cholesterol, and hydrophobic tetrabutyl titanate and natural pigments are prepared. At the same time, it is introduced into the hydrophobic region of the phospholipid bilayer of the liposome, and then the tetrabutyl titanate undergoes a hydrolysis-condensation reaction in situ in the phospholipid bilayer, and a titanium dioxide biomimetic microcapsule is prepared in one step. The invention adopts a one-step method to prepare titanium dioxide biomimetic microcapsules, the raw materials are cheap and easy to obtain, green and environment-friendly, the operation process is simple, the consumption of tetrabutyl titanate is small, the reaction conditions are mild, and the prepared titanium dioxide biomimetic microcapsules have photoelectric conversion function.

Description

technical field [0001] The invention belongs to the technical field of bionano materials, and in particular relates to a preparation method of titanium dioxide biomimetic microcapsules with photoelectric conversion function. Background technique [0002] Liposome is composed of a large hollow water cavity and hydrophobic phospholipids. It has a cell-like structure, good biocompatibility, and can carry various hydrophilic, hydrophobic, and amphiphilic substances. It can be used to control Releases various organic and inorganic compounds. Titanium dioxide can be effectively combined with biomimetic thylakoids due to its low toxicity, good biocompatibility, photocatalysis, and good photoconductivity, for example, Daniel I. et al. (Digest Journal of Nanomaterials and Biostructures, 2010, 5(4), 919-925) reported a preparation method of a liposome containing pure titanium dioxide nanoparticle composite material, which is first prepared by precursor hydrolysis-condensation Titan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02C01G23/053H01G9/20
CPCB01J13/02C01G23/053H01G9/2031Y02E10/542Y02P70/50
Inventor 沈淑坤李雪菲刘晓邦陈建刚胡道道
Owner SHAANXI NORMAL UNIV
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