Application of Mass Spectrometer in Detection of Ionized Intermediates in Catalytic Reaction

Abstract

The invention relates to the application of a mass spectrometer in the process of detecting ionized intermediates in a catalytic reaction. The catalytic reaction is carried out in a catalytic reaction microreactor, and the ion channel inlet of the mass spectrometer is directly connected to the catalytic reaction chamber of the catalytic reaction microreactor. integrated. The main advantage of the present invention is that rapid mass spectrometric detection can be performed on ionized intermediates produced in catalytic reactions without additional sample ionization steps, and rapid mass spectrometric detection can be performed on some reaction intermediates with short lifetimes. The catalytic reaction micro-reactor involved in the invention can be used for reaction mechanism research, rapid and accurate evaluation, optimization and screening of catalyst performance and catalytic reaction conditions.

Description

technical field [0001] The present invention relates to a catalytic reaction micro-reactor, specifically a micro-reactor integrated in the entrance of a mass spectrometer ion channel capable of catalytic reaction and its detection of ionized intermediates in catalytic reaction and evaluation of catalyst performance and catalytic reaction conditions in the application. Background technique [0002] In recent years, mass spectrometry technology has developed rapidly, mainly in faster scanning speed, higher resolution, and higher mass accuracy. For example, the Orbitrap mass spectrometer newly launched by Thermo Electric Company of the United States can simultaneously realize fast high-resolution mass spectrometry scanning. Qualitative ability is significantly improved (Senko M.W., ect, Anal. Chem., 2013, 85, 11710). The application of mass spectrometry to the products and intermediates of chemical reactions, including some long-lived free radical intermediates, has played an ...

AI Technical Summary

Problems solved by technology

However, the existing mass spectrometry technology can only carry out off-line detection of stable products and intermediates after the chemical reaction is completed, and the sample must enter the mass spectrometer through the electrospray ionization process, which has the following disadvantages: (1) For the Intermediate products with a short lifespan cannot be detected; (2) During the process of sample collection, sample injection, electrospray, etc. after the completion of the chemical reaction and before mass spectrometry detection, especially during the electrospray process, additional chemical reactions may occur in the intermediate product. reaction, thus affecting the accuracy of mass spectrometry detection

However, due to the low detection sensitivity and resolution of solid-state nuclear magnetic technology, the types of catalytic reaction intermediates detected are very limited, which limits further research on the reaction mechanism and accurate evaluation of catalyst performance and catalytic reaction conditions.

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