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Lyotropic liquid crystal precursor for root canal disinfection and its preparation method and application

A lyotropic liquid crystal and root canal technology, applied in the field of lyotropic liquid crystal precursors and their preparation, can solve the problems of no application of lyotropic liquid crystal precursors, reduced root canal treatment effect, inability to perform disinfection and sterilization, etc. The effect of releasing long-term root canal sealing, eliminating the blind spot of disinfection, and important practical value

Active Publication Date: 2018-12-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many studies have shown that formocresol has strong irritation, hapten and cytotoxicity, which may cause damage to the periapical tissue, systemic toxic side effects and even the risk of carcinogenic mutagenesis, and the drug is irritated by saliva, blood, plasma , exudate, and many bacterial products will lose their antibacterial ability after being sealed in the root canal for 24 hours; calcium hydroxide paste, iodoform paste, polymer gel, etc. The side branch of the canal has a very small pore size, so it is difficult for the paste and polymer gel to completely fill the root canal when the root canal is sealed. Reduced effectiveness of root canal treatment
However, there are no relevant reports on the application of lyotropic liquid crystal precursors in root canal disinfection.

Method used

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  • Lyotropic liquid crystal precursor for root canal disinfection and its preparation method and application
  • Lyotropic liquid crystal precursor for root canal disinfection and its preparation method and application
  • Lyotropic liquid crystal precursor for root canal disinfection and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1 Preparation and viscosity test of chlorhexidine acetate-nanometer silver-glycerol monooleate lyotropic liquid crystal precursor

[0071] The mass ratio of glycerol monooleate-absolute ethanol-water is an isotropic solution of 12:3:10 as a drug carrier, and chlorhexidine acetate and nano silver are used as medicines for root canal disinfection; The lyotropic liquid crystal precursor for root canal disinfection, its preparation method comprises the following steps:

[0072] Weigh 0.6g of absolute ethanol, add 0.01g, 0.025g and 0.05g of chlorhexidine acetate respectively (the mass fraction of the last gained lyotropic liquid crystal precursor is respectively 0.2%, 0.5% and 1%), then add 2.4 g melted glycerol monooleate at 42°C, mixed evenly, and then added 2 g of finished nano-silver aqueous solutions diluted with water (which contained 0.001 g and 0.0005 g of nano-silver respectively, that is, in the final obtained lyotropic liquid crystal precursor) The mas...

Embodiment 2

[0076] Example 2 In vitro release test of chlorhexidine acetate-nano silver-glycerol monooleate lyotropic liquid crystal precursor

[0077] The in vitro release characteristics of chlorhexidine acetate and nano-silver in lyotropic liquid crystal precursor were investigated by membraneless dissolution method. 0.2g of lyotropic liquid crystal precursor (preparation method is the same as in Example 1, with different contents of chlorhexidine acetate and nano-silver) was dropped into 30ml of deionized water, and simulated in vitro release in a shaker at 37°C and 100rpm, Take 2ml samples at intervals and store them at 4°C for testing, then add an equal amount of release medium to continue simulating in vitro release under the above conditions, and after 30 days, measure chlorhexidine acetate and nano-silver in the lyotropic liquid crystal precursor with a UV spectrophotometer of drug release. The result is as Figure 4 and Figure 5 shown. It can be seen from the results that t...

Embodiment 3

[0079] Example 3 Effects of different adding methods of nano-silver on the physical stability of lyotropic liquid crystal precursors

[0080] According to the preparation method of the lyotropic liquid crystal precursor in Example 1, a lyotropic liquid crystal precursor containing 0.5% chlorhexidine acetate compounded with 0.02% nano-silver was prepared as an experimental group. And the preparation method of the lyotropic liquid crystal precursor of control group comprises the following steps:

[0081] Weigh 0.6g of absolute ethanol, add 0.025g of chlorhexidine acetate, then add 2.4g of glycerol monooleate melted at 42°C, mix well, then add 0.001g of nano-silver powder, and finally add 2g of water dropwise, vortex Spinning and mixing, after centrifugation, sealed and placed at room temperature for one week, the lyotropic liquid crystal precursor compounded with 0.5% chlorhexidine acetate of the control group and 0.02% nano-silver was obtained.

[0082] After standing for a we...

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Abstract

The invention relates to a lyotropic liquid crystal precursor for root canal disinfection and a preparation method thereof.The lyotropic liquid crystal precursor is prepared from a carrier and a root canal disinfection medicine.The carrier is prepared from, by mass, 0.2-5 parts of a liquid crystal material, 1 part of a solvent and 0.1-4.5 parts of water.The mass fraction of the root canal disinfection medicine in the lyotropic liquid crystal precursor is 0.005-3%.The liquid crystal material is monoolein and / or phytantriol; the solvent is the mixture of one or more of absolute ethyl alcohol, N-methyl pyrrolidone, polyethylene glycol and propylene glycol; the root canal disinfection medicine is the mixture of one or more chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, nano silver, calcium hydroxide, metronidazole, tinidazole, ornidazole, iodoform and gallnuts.The lyotropic liquid crystal precursor is good in liquidity, and capable of being injected and entering a lateral root canal easily and eliminating a root canal disinfection blind area and has the effective and lasting root canal disinfection effect.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a lyotropic liquid crystal precursor for root canal disinfection and a preparation method thereof. Background technique [0002] Root canal therapy is the main treatment method for dental pulp disease and periapical disease. It is divided into root canal preparation, root canal disinfection and root canal filling, and root canal disinfection is a core step of root canal treatment. After root canal preparation and root canal irrigation, there are still some necrotic substances or pathogenic bacteria in the deep dentin layer of the side wall, side branch root canals and around the root tip. In order to further eliminate or reduce the root canal Pathogenic bacteria can promote the healing of the periapical tissue, and comprehensive and efficient root canal disinfection should be carried out in the root canal. An ideal root canal disinfectant should have the following properties: (1) broad-s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/00
CPCA61K6/52
Inventor 潘昕郑腾羿吴传斌
Owner SUN YAT SEN UNIV
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