Thermal stable copper metal organic framework material and preparation method and application thereof

Abstract

The invention discloses a thermal stable copper metal organic framework material and a preparation method and application thereof, and relates to the field of pyrrolidine catalysts. A catalyst is the thermal stable copper metal organic framework material, and the chemical formula of the thermal stable copper metal organic framework material is Cu(L)(NO3)2, wherein L represents a 2,3,5,6-tetrafluoro-1,4-bis(1,2,4-triazol-1-methyl)benzene ligand, and NO3 is nitrate anion. Cupric nitrate tetrahydrate and the organic ligand 2,3,5,6-tetrafluoro-1,4-bis(1,2,4-triazol-1-methyl)benzene are subjected to a hydrothermal reaction under an airtight condition, and the copper metal organic framework material with a two-dimensional layered structure is obtained. The synthetic method is high in yield and good in reproducibility; the obtained crystal is high in purity and thermal stability. The copper metal organic framework material has better catalytic activity on catalyzing of tetrahydrofuran gas phase amination, the conversion rate of tetrahydrofuran reaches 72%, and the selectivity of pyrrolidine reaches 90%.

Description

technical field [0001] The invention relates to the field of tetrahydropyrrole catalysts, in particular to a preparation method of a heat-stable copper metal organic framework material and an application of catalytic tetrahydrofuran gas-phase amination. Background technique [0002] Tetrahydropyrrole, also known as pyrrolidine, English name Tetrahydropyrrole or Pyrrolidine, molecular formula C 4 h 9 N, boiling point 87°C, density 0.852gcm –3 , as a cyclic secondary amine, pK b =2.9, it has general amine properties and has extremely wide uses in many aspects. In the field of drug synthesis, there are many kinds of drugs directly having a tetrahydropyrrole structure in the structure, such as buflomedil for treating cerebrovascular disorders, dexmorphilamide tartrate with analgesic function, and procyclone for anti-parkinsonia The anti-infective drug pirromid, the local anesthetic pirrocaine, the depression drug fenprofen and so on. In addition, tetrahydropyrrole is also w...

AI Technical Summary

Problems solved by technology

The catalyst for the cyclization reaction is expensive, and some methods have long synthetic routes, many by-products, and low yields, which do not have the value of actual industrial operation

Using tetrahydrofuran and ammonia as raw materials, tetrahydropyrrole is prepared by gas-phase catalytic method, which has low raw material cost. This synthetic route is used in production, but there are still some problems, such as the catalyst used has low conversion rate and low selectivity.

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